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Highest antigen sequence indentity to the following orthologs: Mouse (55%), Rat (55%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-110858. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: guanine nucleotide regulatory protein (oncogene); Neuroepithelial cell-transforming gene 1 protein; neuroepithelioma transforming gene 1; p65 Net1 proto-oncogene protein; Proto-oncogene p65 Net1; Rho guanine nucleotide exchange factor (GEF) 8; Rho guanine nucleotide exchange factor 8; RP11-116G8.1; small GTP-binding protein regulator
基因别名: ARHGEF8; NET1; NET1A
UniProt ID: (Human) Q12773
Entrez Gene ID: (Human) 10276