Invitrogen

Human Nicastrin Synthetic Peptide

产品信息

PEP-0429

应用

建议稀释比

已发表文章

对照试剂 (Ctrl)

Assay-dependent

阻断反应 (BLOCK)

Assay-dependent

产品规格

种属反应

Human

分类

Synthetic

类型

Peptide

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

200 µg/mL

纯化类型

purified

保存液

PBS, pH 7.2, with 0.1% BSA

内含物

0.02% sodium azide

保存条件

-20°C

产品详细信息

This peptide corresponds to 18 amino acids near the center of human nicastrin.

PEP-0429 can be used as a blocking peptide with polyclonal antibody PA5-20304.

靶标信息

NCSTN (Nicastrin) is a gene that encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21.

仅用于科研。不用于诊断过程。未经明确授权不得转售。