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产品信息
PEP-149
产品规格
分类
Synthetic
类型
Peptide
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
PEP-149 is a 14 amino acid synthetic peptide whose sequences are derived from human PDE6 alpha’ protein. The sequence of this peptide is (amino to carboxy terminus): N (16)-P-Q-F-A-K-E-Y-F-D-R-K-L-R (29)-C
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and human PDE6 alpha', catalog # PA1-721. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions.
Reconstitute with 0.1 mL of distilled water.
靶标信息
This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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