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产品信息
PEP-1476
产品规格
种属反应
Human
分类
Synthetic
类型
Peptide
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
purified
保存液
PBS, pH 7.2, with 0.1% BSA
内含物
0.02% sodium azide
保存条件
-20°C
产品详细信息
This peptide corresponds to 18 amino acid peptide near the amino terminus of human PHLPP1.
PEP-1476 can be used as a blocking peptide with polyclonal antibody PA5-34434.
靶标信息
PHLPP1 is a member of the serine/threonine phosphatase family, which are important regulators of Akt serine-threonine kinases (AKT1, AKT2, AKT3) and conventional/novel protein kinase C (PKC) isoforms. PHLPP1 and PHLPP2 have a similar domain structure and have been shown to dephosphorylate and inactivate, distinct Akt isoforms, at one of the two critical phosphorylation sites required for activation: Serine473. PHLPP2 dephosphorylates AKT1 and AKT3, whereas PHLPP1 is specific for AKT2 and AKT3. PHLPP1 promotes apoptosis and may act as a tumor suppressor. Increased expression of PHLPP1 may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling.
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生物信息学
蛋白别名: EC 3.1.3.16; hSCOP; PH domain leucine-rich repeat-containing protein phosphatase 1; PH domain-containing family E member 1; pleckstrin homology domain containing, family E (with leucine rich repeats) member 1; Pleckstrin homology domain-containing family E member 1; protein phosphatase, Mg2+/Mn2+ dependent 3A; SCN circadian oscillatory protein; Suprachiasmatic nucleus circadian oscillatory protein
基因别名: KIAA0606; PHLPP; PHLPP1; PLEKHE1; PPM3A; SCOP
UniProt ID: (Human) O60346
Entrez Gene ID: (Human) 23239
