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产品信息
PV4413
产品规格
种属
Human
Expression System
Baculovirus
氨基酸序列
178-454
标签
GST-tag
分类
Recombinant
类型
Protein
偶联物
形式
Liquid
浓度
See Label
纯化类型
purified
保存液
proprietary buffer
内含物
no preservative
保存条件
-80° C, Avoid Freeze/Thaw Cycles
运输条件
Dry ice
产品详细信息
Retinoic acid receptor gamma, ligand binding domain (RARG-LBD) is a 58.85 kDa recombinant human protein (amino acids 178-454) expressed as a GST-tagged fusion protein in baculovirus-infected insect cells. RARG-LBD is expressed and purified in the absence of exogenous ligands, making it ideal for ligand binding and coregulator recruitment studies.
Protein Form: Recombinant, Ligand Binding Domain
靶标信息
Retinoic acid, a metabolite of vitamin A, is necessary for normal organogenesis but acts as a teratogen at high levels during embryonic and fetal development. Retinoic acid functions through its interaction with the nuclear protein, retinoic acid receptor (RAR). RAR belongs to the steroid and thyroid hormone superfamily of nuclear receptor proteins which exert their effects by binding to specific DNA response elements, thus regulating gene expression in target cells. RAR exists as three major subtypes: alpha, beta and gamma. Two main isoforms of RAR gamma exist: RAR gamma-1 has been found to be predominantly expressed in skin, while RAR gamma-2 has been found early in embryogenesis and in embryonal carcinoma cells. RAR gamma is also known as RARD. The corresponding gene for the retinoic acid receptor gamma 1 is NR1B3.
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生物信息学
蛋白别名: Nuclear receptor subfamily 1 group B member 3; RAR Gamma-1; RAR-gamma; retinoic acid; retinoic acid nuclear receptor gamma variant 1; retinoic acid nuclear receptor gamma variant 2; retinoic acid receptor; Retinoic acid receptor gamma; retinoic acid receptor, gamma
基因别名: NR1B3; RARC; RARG
UniProt ID: (Human) P13631
Entrez Gene ID: (Human) 5916
