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Highest antigen sequence indentity to the following orthologs: Mouse (97%), Rat (97%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-58788. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Required for maintenance of X inactivation in females and hypermethylation of CpG islands associated with inactive X. Involved in a pathway that mediates the methylation of a subset of CpG islands slowly and requires the de novo methyltransferase DNMT3B. Required for DUX4 silencing in somatic cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: SMC hinge domain-containing protein 1; Structural maintenance of chromosomes flexible hinge domain-containing protein 1
基因别名: KIAA0650; SMCHD1
UniProt ID: (Human) Q9H6Q2
Entrez Gene ID: (Human) 23347