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产品信息
PEP-0862
产品规格
种属反应
Human
分类
Synthetic
类型
Peptide
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
purified
保存液
PBS, pH 7.2, with 0.1% BSA
内含物
0.02% sodium azide
保存条件
-20°C
产品详细信息
This peptide corresponds to 16 amino acids near the carboxy terminus of human ST3gal6.
PEP-0862 can be used as a blocking peptide with polyclonal antibody PA5-20748.
靶标信息
Sialyltransferases catalyze the transfer of sialic acid from cytidine 5-prime monophospho-N-acetylneuraminic acid (CMP-NeuAc) to terminal positions of glycoprotein and glycolipid carbohydrate groups. Terminal NeuAc residues are key determinants of carbohydrate structures, such as the sialyl-Lewis X determinants, and are widely distributed in many cell types. However, cancer cells often express more heavily sialylated glycans on their cell surface and this feature sometimes correlates with invasiveness. In contrast, expression of ST3gal6, a member of the sialyltransferase family that sialylates type II lactosamine structures on glycoproteins and glycolipids, was found to be significantly decreased by hypermethylation of the gene in gastrointestinal cancer. At least three isoforms of ST3gal6 are known to exist.
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生物信息学
蛋白别名: alpha2,3-sialyltransferase ST3Gal VI; CMP-NeuAc:beta-galactoside alpha-2,3-sialyltransferase VI; sia10; Sialyltransferase 10; sialyltransferase 10 (alpha-2,3-sialyltransferase VI); ST3Gal VI; ST3GalVI; Type 2 lactosamine alpha-2,3-sialyltransferase
基因别名: SIAT10; ST3GAL6; ST3GALVI
UniProt ID: (Human) Q9Y274
Entrez Gene ID: (Human) 10402
