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Highest antigen sequence indentity to the following orthologs: Mouse (66%), Rat (66%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-66745. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Plays a role in the negative regulation of NF-kappa-B signaling at the basal level by modulating transcriptional activity of NF-kappa-B on its target gene promoters. Associates with cyclin D1 promoter containing Myc E-box sequence and transcriptionally represses cyclin D1 expression. Regulates telomerase reverse transcriptase expression and telomerase activity in both ALT (alternative lengthening of telomeres)and telomerase-positive cell lines.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: TCEA-like protein 7; transcription elongation factor A (SII)-like 7; Transcription elongation factor A protein-like 7; Transcription elongation factor S-II protein-like 7
基因别名: MPMGp800C04260Q003; TCEAL7; WEX5
UniProt ID: (Human) Q9BRU2
Entrez Gene ID: (Human) 56849