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产品信息
PEP-1233
产品规格
种属反应
Human
分类
Synthetic
类型
Peptide
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
purified
保存液
PBS, pH 7.2, with 0.1% BSA
内含物
0.02% sodium azide
保存条件
-20°C
产品详细信息
This peptide corresponds to 18 amino acids near the amino terminus of human TM4SF1.
PEP-1233 can be used as a blocking peptide with polyclonal antibody PA5-21119.
靶标信息
TM4SF1 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains and mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. TM4SF1 is a cell surface antigen and is highly expressed in the vascular endothelium of several human cancers. Knockdown experiments of TM4SF1 prevented filopodia formation, inhibited cell mobility, blocked cytokinesis, and inhibited maturation of VEGF-A-induced angiogenesis, suggesting that TM4SF1 may be an attractive target for anti-angiogenesis therapy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Membrane component chromosome 3 surface marker 1; membrane component, chromosome 3, surface marker 1; Transmembrane 4 L6 family member 1; transmembrane 4 superfamily member 1; Tumor-associated antigen L6
基因别名: H-L6; L6; M3S1; TAAL6; TM4SF1
UniProt ID: (Human) P30408
Entrez Gene ID: (Human) 4071
