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Human TNF-RII (soluble) Recombinant Protein, PeproTech®

Human TNF-RII (soluble) Protein in Functional Assay (Functional)

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Human TNF-RII (soluble) Protein (310-12-20UG) in Functional

Bioassay analysis of Human TNF-RII (soluble) Recombinant Protein, PeproTech® (Product # 310-12-1MG).

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产品信息

310-12-20UG

应用

建议稀释比

已发表文章

免疫印迹 (WB)

Assay-dependent

酶联免疫吸附实验 (ELISA)

Assay-dependent

查看1篇已发表文章 1篇已发表文章

功能检测 (Functional)

Assay-dependent

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体外检测 (IV)

查看6篇已发表文章 6篇已发表文章

其他PubMed (Misc)

查看1篇已发表文章 1篇已发表文章

产品规格

种属

Human

已发表种属

Human, Mouse, Rat

Expression System

E. coli

氨基酸序列

MAPEPGSTCR LREYYDQTAQ MCCSKCSPGQ HAKVFCTKTS DTVCDSCEDS TYTQLWNWVP ECLSCGSRCS SDQVETQACT REQNRICTCR PGWYCALSKQ EGCRLCAPLR KCRPGFGVAR PGTETSDVVC KPCAPGTFSN TTSSTDICRP HQICNVVAIP GNASMDAVCT STSP

分子量

18.9 kDa

分类

Recombinant

类型

Protein

纯度

≥ 98% by SDS-PAGE gel and HPLC analyses.

内毒素浓度

<1 EU/µg

活性

Determined by its inhibitory effect of the TNF-alpha mediated cytotoxicity in murine L-929 cells. The ED50 for this effect in the presence of 0.25 ng/ml of Recombinant Human TNF-alpha, is 0.125 ug/ml.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

纯化类型

purified

内含物

no preservative

保存条件

-20°C

运输条件

Ambient

产品详细信息

Recombinant Human sTNF Receptor Type II is an 18.9 kDa protein (174 amino acid residues) comprising the cysteine-rich, ligand binding portion of the extracellular domain of the TNFRII protein.

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

靶标信息

TNFR2 (tumor necrosis factor receptor superfamily member 1B) is a receptor with high affinity for TNFSF2/TNF-alpha. It has a much lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. TNFR2 mediates most of the metabolic effects of TNF-alpha.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Generation of a single-cell B cell atlas of antibody repertoires and transcriptomes to identify signatures associated with antigen specificity.

iScience

Agrafiotis A,Neumeier D,Hong KL,Chowdhury T,Ehling R,Kuhn R,Sandu I,Kreiner V,Cotet TS,Shlesinger D,Laslo D,Anzböck S,Starkie D,Lightwood DJ,Oxenius A,Reddy ST,Yermanos A

310-12 was used in In vivo experiments to determine the relationship between antibody repertoires, gene expression signatures, and antigen specificity across 100,000 B cells.

Fri Mar 17 00:00:00 UTC 2023

Generation of a single-cell B cell atlas of antibody repertoires and transcriptomes to identify signatures associated with antigen specificity.

iScience

Agrafiotis A,Neumeier D,Hong KL,Chowdhury T,Ehling R,Kuhn R,Sandu I,Kreiner V,Cotet TS,Shlesinger D,Laslo D,Anzböck S,Starkie D,Lightwood DJ,Oxenius A,Reddy ST,Yermanos A

310-12 was used in In vivo experiments to determine the relationship between antibody repertoires, gene expression signatures, and antigen specificity across 100,000 B cells.

Fri Mar 17 00:00:00 UTC 2023

Profiling the specificity of clonally expanded plasma cells during chronic viral infection by single-cell analysis.

European journal of immunology

Neumeier D,Pedrioli A,Genovese A,Sandu I,Ehling R,Hong KL,Papadopoulou C,Agrafiotis A,Kuhn R,Shlesinger D,Robbiani D,Han J,Hauri L,Csepregi L,Greiff V,Merkler D,Reddy ST,Oxenius A,Yermanos A

310-12 was used in In vivo experiments to investigate plasma cell antibody production.

Tue Feb 01 00:00:00 UTC 2022

Characterization and Application of a Unique Panel of Monoclonal Antibodies Generated against Etanercept.

Journal of immunology (Baltimore, Md. : 1950)

Detrez I,Brouwers E,Peeters M,Geukens N,de Vlam K,Gils A

Tue Mar 15 00:00:00 UTC 2016

High-throughput proteomics reveal alarmins as amplifiers of tissue pathology and inflammation after spinal cord injury.

Scientific reports

Didangelos A,Puglia M,Iberl M,Sanchez-Bellot C,Roschitzki B,Bradbury EJ

Mon Feb 22 00:00:00 UTC 2016

Screening of an anti-inflammatory peptide from Hydrophis cyanocinctus and analysis of its activities and mechanism in DSS-induced acute colitis.

Scientific reports

Zheng Z,Jiang H,Huang Y,Wang J,Qiu L,Hu Z,Ma X,Lu Y

Mon May 09 00:00:00 UTC 2016

Fusion of HSA influences TNF-α neutralizing activity of shTNFRs.

Biotechnology letters

Zhan J,Chen Y,Yuan HY,Li H,Lu H

Thu Mar 01 00:00:00 UTC 2012

Novel role for the innate immune receptor Toll-like receptor 4 (TLR4) in the regulation of the Wnt signaling pathway and photoreceptor apoptosis.

PloS one

Yi H,Patel AK,Sodhi CP,Hackam DJ,Hackam AS

Fri Sep 14 00:00:00 UTC 2012

Crystallization and preliminary X-ray analysis of the tumour necrosis factor alpha-tumour necrosis factor receptor type 2 complex.

Acta crystallographica. Section F, Structural biology and crystallization communications

Mukai Y,Nakamura T,Yoshioka Y,Tsunoda S,Kamada H,Nakagawa S,Yamagata Y,Tsutsumi Y

Sun Mar 01 00:00:00 UTC 2009

生物信息学

蛋白别名: CD120b; p75; p75 TNF receptor; p80 TNF-alpha receptor; sCD120b; soluble CD120b; soluble TNFR1B variant 1; soluble TNFR2; sTNF R2; sTNFR 2; sTNFR2; TNF-R2; TNF-RII; TNFR; TNFR II; tumor necrosis factor beta receptor; tumor necrosis factor binding protein 2; Tumor necrosis factor receptor; Tumor necrosis factor receptor 2; Tumor necrosis factor receptor superfamily member 1B; tumor necrosis factor receptor superfamily, member 1B; Tumor necrosis factor receptor type II

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基因别名: CD120b; p75; p75TNFR; TBPII; TNF-R-II; TNF-R75; TNFBR; TNFR1B; TNFR2; TNFR80; TNFRSF1B

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UniProt ID: (Human) P20333

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Entrez Gene ID: (Human) 7133

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Human TNF-RII (soluble) Recombinant Protein, PeproTech®

Human TNF-RII (soluble) Protein (310-12-20UG) in Functional

产品信息

310-12-20UG

免疫印迹 (WB)

酶联免疫吸附实验 (ELISA)

功能检测 (Functional)

体外检测 (IV)

其他PubMed (Misc)

种属

已发表种属

Expression System

氨基酸序列

分子量

分类

类型

纯度

内毒素浓度

活性

偶联物

形式

纯化类型

内含物

保存条件

运输条件

产品详细信息

靶标信息

生物信息学

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