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Highest antigen sequence indentity to the following orthologs: Mouse (91%), Rat (91%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-83281. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
TPRKB is a component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TPRKB acts as an allosteric effector that regulates the t6A activity of the complex. TPRKB is not required for tRNA modification.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: EKC/KEOPS complex subunit TPRKB; PRPK (p53-related protein kinase)-binding protein; PRPK-binding protein; TP53RK-binding protein; WBSCR18
基因别名: CGI-121; CGI121; My019; TPRKB
UniProt ID: (Human) Q9Y3C4
Entrez Gene ID: (Human) 51002