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产品信息
PEP-1125
产品规格
种属反应
Human
分类
Synthetic
类型
Peptide
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
purified
保存液
PBS, pH 7.2, with 0.1% BSA
内含物
0.02% sodium azide
保存条件
-20°C
产品详细信息
This peptide corresponds to 15 amino acids near the carboxy terminus of human TRIM71.
PEP-1125 can be used as a blocking peptide with polyclonal antibody PA5-21011.
靶标信息
TRIM71 is the mammalian ortholog to the C. elegans heterochronic protein Lin41, a protein that is thought to be important in postembryonic development, and is genetically and biochemically downstream of both Shh and Fgf signaling pathways. Similar to its C. elegans homolog, TRIM71 is a target of the microRNA let-7 and is likely to play a role in mammalian development. Recent experiments have indicated that TRIM71 is an E3 ubiquitin ligase and can interact with the Dicer and the Argonaute proteins Ago1, Ago2, and Ago4. Overexpression and depletion of TRIM71 led to inverse changes in Ago2 protein levels, suggesting TRIM71 can regulate Ago2 turnover. Finally, TRIM71 cooperates with the pluripotency factor Lin-28 in regulating let-7.
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生物信息学
蛋白别名: abnormal cell LINeage LIN-41; E3 ubiquitin-protein ligase TRIM71; homolog of C. elegans Lin-41; Protein lin-41 homolog; RING-type E3 ubiquitin transferase TRIM71; tripartite motif containing 71, E3 ubiquitin protein ligase; tripartite motif-containing 71; Tripartite motif-containing protein 71
基因别名: LIN-41; LIN41; TRIM71
UniProt ID: (Human) Q2Q1W2
Entrez Gene ID: (Human) 131405
