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产品信息
RP-103240
产品规格
种属
Human
Expression System
E. coli
氨基酸序列
VGSGPHPPDTQQPSPSKAFKPRFPGDQVVNGAGPELSTGPSPGSPTLDIDQSIEQLNRLILELDPTFEPIPTHMNALGSQANGSV
标签
His-ABP-tag
分类
Recombinant
类型
Protein
纯度
>80% by SDS-PAGE and Coomassie blue staining
偶联物
形式
Liquid
浓度
≥5.0 mg/mL
纯化类型
purified
保存液
PBS/1M urea, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
Highest antigen sequence indentity to the following orthologs: Mouse (69%), Rat (69%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-63238. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
靶标信息
The Tensin (Tns) family of proteins is involved in the maintenance of cellular structure by anchoring actin filaments at the focal adhesion via F-actin binding and capping activities. Tns proteins also contain a Src homology 2 (SH2) domain and have the ability to be phosphorylated, suggesting a role in signal transduction cascades. These diverse characteristics indicate that Tns proteins may be important links between the cytoskeleton and signal transduction pathways. Tns3, also known as TEM6 or TENS1, localizes to the focal adhesions of the plasma membrane. It is predominantly expressed in thyroid and placenta but can also be found in heart, liver, brain, prostate, pancreas, kidney, lung, skeletal muscle and white blood cells. Tns3 is essential for proper growth and development, as suggested by growth retardation and death in a number of Tns3-/- mice.
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生物信息学
蛋白别名: TENS3; Tensin-3; tensin-like SH2 domain containing 1; tensin-like SH2 domain-containing 1; Tensin-like SH2 domain-containing protein 1; thyroid specific PTB domain protein; Tumor endothelial marker 6
基因别名: TEM6; TENS1; TNS3; TPP
UniProt ID: (Human) Q68CZ2
Entrez Gene ID: (Human) 64759
