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产品信息
PEP-1590
产品规格
种属反应
Human
分类
Synthetic
类型
Peptide
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
purified
保存液
PBS, pH 7.2, with 0.1% BSA
内含物
0.02% sodium azide
保存条件
-20°C
产品详细信息
This peptide corresponds to 16 amino acid peptide near the carboxy terminus of human CRTC2.
PEP-1590 can be used as a blocking peptide with polyclonal antibody PA5-34547. For use as a blocking peptide in Western blot, incubate the peptide with equal volume of antibody for 30 min at 37ºC.
靶标信息
CRTC2, also known as TORC2 (Transducers Of Regulated cAMP Response Element-Binding (CREB)) 2 and the related protein CRTC1 are potent CREB coactivators that are exported from the nucleus in a CRM1-dependent manner via phosphorylation-dependent interactions. Studies suggest that their phosphorylation and nuclear/cytoplasmic shuttling play an important role in the regulation of gluconeogenesis by cAMP. CRTC2 is present in both B and T-lymphocytes and abundantly expressed in the thymus. Its activity is important in regulating the expression of genes involved in cellular energy metabolism while CRTC1 is essential for energy balance and fertility.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CREB-regulated transcription coactivator 2; OTTHUMP00000035255; TORC-2; transducer of regulated cAMP response element-binding protein (CREB) 2; Transducer of regulated cAMP response element-binding protein 2
基因别名: CRTC2; TORC-2; TORC2
UniProt ID: (Human) Q53ET0
Entrez Gene ID: (Human) 200186
