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产品信息
PEP-235
产品规格
种属反应
Human
分类
Synthetic
类型
Peptide
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
纯化类型
purified
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
PEP-235 is a 9 amino acid synthetic peptide corresponding to amino acid residues 436-441 from human Versican. The sequence of this peptide is (amino to carboxy terminus): C G G D (436) P E A A E (441).
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product, catalog # PA1-1748A. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions.
Reconstitute with 0.1 mL of distilled water.
靶标信息
Versican is a member of the family of large aggregating proteoglycans (also including aggrecan, brevican, and neurocan). The protein shows wide tissue distribution which includes fibrous, articular, and elastic cartilages, as well as nervous, epidermal, arterial, and loose connective tissues. Versican V1 has been shown to enhance cell proliferation, and also induce cell transformation and protect cells from apoptosis. This was demonstrated through its ability to downregulate the expression of proapoptotic Bad. Versican's existence as a extracellular matrix protein in human airways has also lead to the discovery of an inflammatory role in asthmatics.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Chondroitin sulfate proteoglycan 2; Chondroitin sulfate proteoglycan core protein 2; GHAP; Glial hyaluronate-binding protein; Large fibroblast proteoglycan; PG-M; PGM; V1 Neo; Versican core protein; versican proteoglycan; Versican V0; WGN 1
基因别名: CSPG2; ERVR; GHAP; PG-M; VCAN; WGN; WGN1
UniProt ID: (Human) P13611
Entrez Gene ID: (Human) 1462
