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Highest antigen sequence indentity to the following orthologs: Mouse (50%), Rat (50%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-62064. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Glucagon is initially synthesized as proglucagon, which is 180 amino acids in length and is cleaved proteolytically. It contains a region corresponding to Glucagon itself, in addition to a signal peptide, spacer regions and two Glucagon-like peptide sequences. GLP1 is encoded by the fourth exon of the six in the human Glucagon gene. It is 37 amino acids in length and has 48% amino acid sequence homology to Glucagon, and is thought to have arisen by gene duplication. The sequence of GLP1 is conserved across many species, however, indicating that it has a particular function. GLP1 is a potent insulin secretagogue, renders pancreatic beta cells 'glucose-competent' and may be useful in the treatment of diabetes mellitus.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: GATA like protein 1; GATA like protein-1; GATA zinc finger domain containing 3; GATA-like protein 1; GATA-type zinc finger protein 1; GLP-1
基因别名: GATAD3; GLP-1; GLP1; ZGLP1
UniProt ID: (Human) P0C6A0
Entrez Gene ID: (Human) 100125288