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产品信息
PEP-1180
产品规格
种属反应
Human
分类
Synthetic
类型
Peptide
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
purified
保存液
PBS, pH 7.2, with 0.1% BSA
内含物
0.02% sodium azide
保存条件
-20°C
产品详细信息
This peptide corresponds to 16 amino acids near the amino terminus of human ZIP1.
PEP-1180 can be used as a blocking peptide with polyclonal antibody PA5-21066.
靶标信息
ZIP1, also known as ZIRTL (zinc-iron regulated transporter-like), is the first mammalian member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP1 expression is markedly downregulated in a number of cancerous tissues and is thought to function as a tumor suppressor gene in prostate cancer. More recent studies have shown that overexpression of ZIP1 and concomitant increased levels of intracellular zinc in PC-3 cells cause a significant inhibition of NF-kappa-B, leading to down-regulation of the antiapoptotic protein Bcl-2, Bcl-XL, and the apoptosis inhibitor XIAP, reducing the malignant potential of prostate cancer cells in vitro and in vivo.
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生物信息学
蛋白别名: solute carrier family 39 (zinc transporter), member 1; solute carrier family 39 (zinc transporter), member 3; Solute carrier family 39 member 1; Zinc transporter ZIP1; Zinc-iron-regulated transporter-like; ZIP-1; Zrt- and Irt-like protein 1
基因别名: CGI-08; CGI-71; IRT1; SLC39A1; ZIP1; ZIRTL
UniProt ID: (Human) Q9NY26
Entrez Gene ID: (Human) 27173
