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产品信息
RP-8636
产品规格
Expression System
E. coli
分类
Recombinant
类型
Protein
偶联物
形式
Lyophilized
浓度
0.1 mg/mL
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
Recombinant rat IL-17E is a non-glycosylated, disulfide-linked homodimer, containing two 145 amino acid proteins , with a total molecular weight of 35.5 kDa. Purity is typically greater than 97% and endotoxin level less than 1 EU/ug.
The expected biological activity (ED50) is determined by the dose-dependent induction of human IL-8 production in cultured human PBMCs and is typically less than 100 ng/mL. The specific activity of this protein is 1x10^4 units/mg.
Reconstitute using sterile 20mM HCl at 0.1 mg/mL and centrifuge prior to opening vial. Gently pipet solution down the sides of the vial. DO NOT VORTEX sample. Store reconstituted material at -20ºC and add 0.1% BSA for additional stability.
Amino acid sequence: CSHLPRCCPS KQQEFPEEWL KWNPAPVSPP EPLRHTHHPE SCRASKDGPL NSRAISPWSY ELDRDLNRVP QDLYHARCLC PHCVSLQTGS HMDPMGNSVP LYHNQTVFYR RPCHGEQGAH GRYCLERRLY RVSLACVCVR PRMMA.
靶标信息
Interleukin 25 (IL-25) is a member of the IL-17 family and is identified as a proinflammatory cytokine which is produced by Th17 effector cells thus enabling the Th17 subset to initiate or maintain the autoimmune process in diseases such as Rheumatoid Arthritis. IL-25 also induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. IL-25 itself is activated through IL-23, IL-5, and TGF-beta.
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