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产品信息
315-40-20UG
产品规格
种属
Mouse
已发表种属
Mouse
Expression System
E. coli
氨基酸序列
NLHLLRQKIE EQAAKYKHSV PKKCCYDGAR VNFYETCEER VARVTIGPLC IRAFNECCTI ANKIRKESPH KPVQLGR
分子量
8.9 kDa
分类
Recombinant
类型
Protein
纯度
≥ 98% by SDS-PAGE gel and HPLC analyses.
内毒素浓度
<1 EU/µg
活性
Measured by its ability to support adhesion of Human Umbilical Vein Endothelial Cells (HUVEC) to the Recombinant Murine C5a-coated surface.
偶联物
形式
Lyophilized
纯化类型
purified
内含物
no preservative
保存条件
-20°C
运输条件
Ambient
产品详细信息
Recombinant Murine C5a is an 8.9 kDa glycoprotein containing the 77 amino acid residues of the C5a anaphylatoxin chain.
This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
靶标信息
The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: C4B1; C4B12; C4B2; C4B3; C4B5; C4F; CH; CO4; Complement C5; CPAMD3; DADB-112B14.11; FLJ17816; FLJ17822; FLJ60561; Hemolytic complement; MGC142298; MGC164979
基因别名: C5; C5a; Hc; He
UniProt ID: (Mouse) P06684
Entrez Gene ID: (Mouse) 15139
