Invitrogen

Mouse PCSK2 (aa 622-638) Synthetic Peptide

产品信息

PEP-138

应用

建议稀释比

已发表文章

对照试剂 (Ctrl)

Assay-dependent

产品规格

种属反应

Mouse

分类

Synthetic

类型

Peptide

偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

0.5 mg/mL

纯化类型

purified

内含物

no preservative

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

产品详细信息

PEP-138 is a 17 amino acid synthetic peptide whose sequences are derived from mouse PC2 protein. The sequence of this peptide is (amino to carboxy terminus): E (622)-L-D-E-A-V-E-R-S-L-Q-S-I-L-R-K-N (638).

This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and mouse PC2, catalog # PA1-058. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions.

Reconstitute with 0.1 mL of distilled water.

靶标信息

The subtilisin-like prohormone convertase (PC) family is a group of cellular enzymes that cleave most prohormones and neuropeptide precursors. Numerous other cellular proteins, some viral proteins, and bacterial toxins that are transported by the constitutive secretory pathway are also targeted for maturation by PCs. PC family members share structural similarities, which include a heterogeneous approximately 10 kDa amino-terminal proregion, a highly conserved approximately 55 kDa subtilisin-like catalytic domain, and carboxyl-terminal domain that is heterogeneous in length and sequence. These enzymes become catalytically active following proregion cleavage within the appropriate cellular compartment. The subcellular localization of PC family members varies. Immunolocalization studies show that PC1 is found in the perinuclear region as well as the trans-Golgi network, whereas PC2 can be found in the trans-Golgi network as well as diffusely distributed in the peripheral cytoplasm.

仅用于科研。不用于诊断过程。未经明确授权不得转售。