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产品信息
RP-88256
产品规格
种属
Mouse
Expression System
HEK293 cells
氨基酸序列
Mouse ROR1, amino acids Met1-Glu403 (Accession # NP_038873.2) with a C-terminal His-tag
标签
His-tag
分子量
59.4 kDa
分类
Recombinant
类型
Protein
纯度
>95% as determined by SDS-PAGE.
内毒素浓度
<1.0 EU/µg
偶联物
形式
Lyophilized
纯化类型
purified
保存液
PBS, pH 7.4, with 0.01% mannitol, 5-8% trehalose, 0.01% Tween 80
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
It is recommended that the protein be aliquoted for optimal storage.
It is recommended that sterile water (800 µL) be added to the vial to prepare a stock solution of 1.25 mg/mL.
Concentration is measured by UV.
靶标信息
Receptor-tyrosine-kinase-like orphan receptor 1 (ROR1) is a tumor-associated, surface protein predominantly expressed during embryogenesis, where it is involved in organ morphogenesis, nervous system development, and neural progenitor cell maintenance and survival. Virtually absent from normal pediatric and adult tissues, with the exception of low-level expression in a subset of immature b cell precursors known as hematogones and adipocytes, ROR1 is notably overexpressed, and considered a survival factor, in a number of B lymphoid and epithelial malignancies: including chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), acute lymphoblastic leukemia (ALL), marginal zone lymphoma, lung adenocarcinoma. First identified during PCR-based cloning of a human neuroblastoma cell line in search of tyrosine kinases similar to tropomyosin-receptor-kinase (Trk) neurotropic receptors, ROR1, along with the related receptor tyrosine kinase (RTK) ROR2, was catalogued as an "orphan" receptor due to the fact its related ligand remained elusive. Wnt-5a has since been suggested as a candidate ligand for ROR1, and ROR1 has been implicated to function as a pseudokinase, promoting proliferation and resistance to apoptosis in cancer cells through interaction with Wnt-5a, and TCL1-co-activation of AKT. ROR1 is expressed as a glycoprotein containing extracellular immunoglobulin (Ig)-like, Frizzled, and Kringle domains, as well as an intracellular region containing a tyrosine kinase domain.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Inactive tyrosine-protein kinase transmembrane receptor ROR1; MGC99659; mROR1; neurotrophic tyrosine kinase, receptor related 1; Neurotrophic tyrosine kinase, receptor-related 1; T-ROR1; tyrosine-protein kinase transmembrane receptor ROR1
基因别名: 2810404D04Rik; mRor1; Ntrkr1; Ror1
UniProt ID: (Mouse) Q9Z139
Entrez Gene ID: (Mouse) 26563
