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Invitrogen
Mouse/Rat/Guinea Pig LAMP2 (aa 400-411) synthetic peptide Synthetic Peptide
产品信息
PEP-039
产品规格
种属反应
Guinea pig,
Mouse,
Rat
分类
Synthetic
类型
Peptide
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
纯化类型
purified
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
PEP-039 is a 13 amino acid synthetic peptide whose sequence corresponds to cytoplasmic domain amino acid residues 400-411 of rat LAMP-2 protein. This sequence is completely conserved between rat, mouse, and guinea pig LAMP-2. The sequence of this peptide is (amino to carboxy terminus): (C)-G400-L-K-R-H-H-T-G-Y-E-Q-F411 (A cysteine residue was added to facilitate coupling KLH).
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and rat LAMP-2, catalog # PA1-655. Using a solution with equal weights per unit volume of peptide and corresponding antibody will yield a solution with a large molar excess of peptide that is able to competitively bind the antibody.
Reconstitute with 0.1 mL of distilled water.
靶标信息
LAMP2 (Lysosome-associated membrane glycoprotein 2, CD107b) is a member of a family of membrane glycoproteins. LAMP2 provides selectins with carbohydrate ligands, and may play a role in tumor cell metastasis, and have a function in the protection, maintenance, and adhesion of the lysosome. Prior to posttranslational modification, LAMP2 is approximately 46 kDa polypeptide. Mature, functional LAMP2 is extensively glycosylated with a variety of different N-linked and O-linked oligosaccharides with a total molecular weight of about 100-130 kDa. LAMP 2 has a structure comprised of a large amino-terminal intra-lysosomal domain, a hydrophobic trans-membrane domain, and a short carboxyl-terminal cytoplasmic tail. LAMP2 is used to monitor a very selective form of autophagy called chaperone-mediated autophagy. LAMP 2 has a structure comprised of a large amino-terminal intra-lysosomal domain, a hydrophobic trans-membrane domain, and a short carboxyl-terminal cytoplasmic tail. The LAMP protein has 3 variant forms: LAMP-2A, -2B, and 2C. LAMP2, together with CD107a/LAMP-1, is a major constituent of lysosomal membrane. The LAMP proteins are involved in lysosome biogenesis and are required for fusion of lysosomes with phagosomes, and LAMP2 is an important regulator in successful phagosomal maturation. LAMP2 deficiency causes an accumulation of autophagosomes in many tissues leading to cardiomyopathy and myopathy (Danon’s disease).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD107 antigen-like family member B; CD107b; Igp96; LAMP-2; LAMP-2 Isoform 2A; LAMP-2 Variant A; LGP-110; LGP-96; LGP-B; lysosomal membrane glycoprotein 2; Lysosomal membrane glycoprotein type B; Lysosome-associated membrane glycoprotein 2; lysosome-associated membrane protein 2; RP23-193O17.2
基因别名: CD107b; Lamp II; Lamp-2; Lamp-2a; Lamp-2b; Lamp-2c; Lamp2; LGP-B; Mac3
UniProt ID: (Mouse) P17047, (Rat) P17046
Entrez Gene ID: (Mouse) 16784, (Rat) 24944
