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Invitrogen
Rat Androgen Receptor, Ligand Binding Domain, GST Tag, His Tag Recombinant Protein
产品信息
A15675
产品规格
种属
Rat
Expression System
Baculovirus
氨基酸序列
606-902
标签
GST-tag, His-tag
分类
Recombinant
类型
Protein
偶联物
形式
Liquid
浓度
See Label
纯化类型
purified
保存液
proprietary buffer
内含物
no preservative
保存条件
-80° C, Avoid Freeze/Thaw Cycles
运输条件
Dry ice
产品详细信息
Androgen receptor ligand binding domain (AR-LBD) is a 64.42 kDa recombinant rat protein, expressed as a GST- and His-tagged protein in insect cells. The protein contains the hinge region and an LBD amino acid sequence identical to that of the human LBD. Differences in the rat and human hinge region are present at human amino acids 646, 649, 650, 655, 656, 657, and 660. AR-LBD is expressed and purified in the absence of exogenous ligands, making it ideal for ligand-binding and coregulator recruitment studies.
AR-LBD rat recombinant protein is:
• Flexible—use in your in-house assay or as part of our PolarScreen™ Competitor assays for a complete assay solution
• Ready to use—active and tagged (with GST/His)
• Convenient—available in bulk sizes
Contact us for bulk quantities or for assistance with other nuclear receptor assay needs, from assay development to library screening and beyond.
Protein Form: Ligand Binding Domain, Recombinant
靶标信息
The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. The receptor is more than 90 kDa and has three major functional domains: the N-terminal domain, DNA-binding domain, and the androgen-binding domain. The androgen receptor is a ligand-activated transcription factor that binds active testosterone (T) and dihydrotestosterone (DHT). Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. The AR signaling pathway plays a key role in development and function of male reproductive organs, including the prostate and epididymis. AR also plays a role in nonreproductive organs, such as muscle, hair follicles, and brain. Androgen Receptor is a phosphoprotein, and also regulates mitogen-activated protein kinase (MAP kinase). The inhibition of the MEK1/2 pathway correlates directly with a change in phosphorylation state of the androgen receptor. Abnormalities in the AR signaling pathway have been linked to a number of diseases, including prostate cancer, Kennedy's disease, and male infertility. Mutations in this gene are associated with complete androgen insensitivity (CAIS).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Androgen receptor; androgen receptor (Testicular feminization), same as Tfm; AR-A; Dihydrotestosterone receptor; Nuclear receptor subfamily 3 group C member 4; RP11-383C12.1; Variant AR45
基因别名: Andr; Ar; Nr3c4; Tfm
UniProt ID: (Rat) P15207
Entrez Gene ID: (Rat) 24208
