Invitrogen

Rat Leptin Receptor (aa 577-594) Synthetic Peptide

产品信息

PEP-014

应用

建议稀释比

已发表文章

对照试剂 (Ctrl)

Assay-dependent

产品规格

种属反应

Rat

分类

Synthetic

类型

Peptide

偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

0.5 mg/mL

纯化类型

purified

内含物

no preservative

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

产品详细信息

PEP-014 is an 18 amino acid (amino acids 577-594) synthetic peptide whose sequence is from the extracellular domain of the leptin receptor (OB-R). The sequence of this peptide is (amino to carboxy terminus): K-E-I-Q-W-K-T-H-E-V-F-D-A-K-S-K-S-A

This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and leptin receptor (OB-R), catalog # PA1-053. Using a solution with equal weights per unit volume of peptide and corresponding antibody will yield a solution with a large molar excess of peptide that is able to competitively bind the antibody.

Reconstitute with 0.1 mL of distilled water.

靶标信息

The leptin (OB-R) receptor is a member of the cytokine receptor superfamily which plays an important role in mammalian body weight homeostasis and energy balance. Ligand-induced activation of the OB-R by the adipose tissue-secreted hormone, leptin, appears to activate downstream signaling events through the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway. Leptin can homo-dimerize OB-R extracellular domains while downstream signaling events are initiated upon homo-dimerization of OB-R intracellular domains. Several isoforms of the OB-R which differ in length and signaling capabilities have been reported. RNA transcripts encoding the OB-R long form have been found in the choroid plexus and in the hypothalamus which has been proposed as a control center for satiety and energy expenditure. Mutations in either the mouse OB-R (db) or leptin (ob) genes have been shown to result in early-onset obesity. Metabolic abnormalities attributable to these genotypes include hypercorticoidemia, hyperinsulinemia and insulin resistance, hyperglycemia, altered CNS activity, reduced metabolic rate of brown adipose tissue, and a large increase in white adipose tissue.

仅用于科研。不用于诊断过程。未经明确授权不得转售。