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产品信息
PEP-101
产品规格
种属反应
Rat
分类
Synthetic
类型
Peptide
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
纯化类型
purified
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
PEP-101 is a 18 amino acid synthetic peptide whose sequence corresponds to amino acid residues 1-18 of rat VAMP-2. The sequence of this peptide is (amino to carboxy terminus): M (1)-S-A-T-A-A-T-V-P-P-A-A-P-A-G-E-G-G (18)
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and rat VAMP-2, catalog # PA1-766. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions.
Reconstitute with 0.1 mL of distilled water.
靶标信息
The vesicle associated membrane proteins (VAMP) or synaptobrevins are calcium binding proteins specific to eukaryotes. VAMPs, along with synaptosomal associated protein of 25 kDa (SNAP-25) and syntaxin, form the core complex of soluble NSF attachment protein receptor (SNARE) proteins that interact with the soluble proteins N-ethylmaleimide-sensitive factor (NSF) and alpha-SNAP. These membrane associated proteins play a key role in the regulation of vesicle membrane fusion with the plasma membrane. The Clostridium tetani neurotoxin is a metalloprotease with specificity for VAMP. In Alzheimer's disease, VAMP levels of all isoforms appear to be significantly lowered. It is suggested that VAMP-2 is a resident protein of the insulin-sensitive glucose transporter type 4 (GLUT4) compartment and that it is required for GLUT4 vesicle incorporation into the cell surface in response to insulin.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Synaptobrevin; Synaptobrevin 2 (vesicle-associated membrane protein VAMP-2); Synaptobrevin-2; vamp; VAMP-2; Vesicle-associated membrane protein (synaptobrevin 2); Vesicle-associated membrane protein 2
基因别名: RATVAMPB; RATVAMPIR; SYB; Syb2; Vamp2
UniProt ID: (Rat) P63045
Entrez Gene ID: (Rat) 24803
