靶标信息
ATP6V0C is a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. ATP6V0C encodes the V0 subunit c.
同义词
Atp6c; Atp6c2; Atp6l; Atp6v0c; ATPase H+ transporting V0 subunit c; ATPase, H+ transporting, lysosomal (vacuolar proton pump) 16 kDa; ATPase, H+ transporting, lysosomal 16kD, V0 subunit C; ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c; ATPase, H+ transporting, lysosomal 2; ATPase, H+ transporting, lysosomal V0 subunit C; Atpl; Atpl-rs1; H(+)-ATPase (mvp); H(+)-transporting two-sector ATPase, 16 kDa subunit; Mvp; PL16; vacuolar ATP synthase 16 kDa proteolipid subunit; vacuolar H+ ATPase proton channel subunit; vacuolar proton pump 16 kDa proteolipid subunit; VATL; V-ATPase 16 kDa proteolipid subunit; Vma3; VPPC; V-type proton ATPase 16 kDa proteolipid subunit