Antibodies that detect Fibronectin can be used in several scientific applications, including Immunohistochemistry, Immunocytochemistry, Western Blot, ELISA and SDS-PAGE. These antibodies target Fibronectin in Human, Mouse, Rat, Porcine and Bovine samples. Our Fibronectin monoclonal,...Antibodies that detect Fibronectin can be used in several scientific applications, including Immunohistochemistry, Immunocytochemistry, Western Blot, ELISA and SDS-PAGE. These antibodies target Fibronectin in Human, Mouse, Rat, Porcine and Bovine samples. Our Fibronectin monoclonal, polyclonal and recombinant monoclonal antibodies are...Antibodies that detect Fibronectin can be used in several scientific applications, including Immunohistochemistry, Immunocytochemistry, Western Blot, ELISA and SDS-PAGE. These antibodies target Fibronectin in Human, Mouse, Rat, Porcine and Bovine samples. Our Fibronectin monoclonal, polyclonal and recombinant monoclonal antibodies are developed in Mouse and Rabbit. These antibodies have been verified by Knockout, Relative expression, Cell treatment and Knockdown to confirm specificity to Fibronectin. Find the Fibronectin antibody that fits your needs. Choose from 1 of 98 Fibronectin antibodies, which have been validated in experiments with 114 publications and 337 images featured in our data gallery.
Browse primary...
Antibodies that detect Fibronectin can be used in several scientific applications, including Immunohistochemistry, Immunocytochemistry, Western Blot, ELISA and SDS-PAGE. These antibodies target Fibronectin in Human, Mouse, Rat, Porcine and Bovine samples. Our Fibronectin monoclonal, polyclonal and recombinant monoclonal antibodies are developed in Mouse and Rabbit. These antibodies have been verified by Knockout, Relative expression, Cell treatment and Knockdown to confirm specificity to Fibronectin. Find the Fibronectin antibody that fits your needs. Choose from 1 of 98 Fibronectin antibodies, which have been validated in experiments with 114 publications and 337 images featured in our data gallery.
Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Antibodies with Advanced Verification data have been validated for specificity to ensure that the antibody binds to the antigen stated. If you cannot find the antibody you're looking for, contact us today to develop custom antibodies for specific targets, species and applications.
靶标信息
Fibronectin is a disulfide-bonded dimer with a molecular weight range of 230-250 kDa. In the extracellular matrix of several connective tissues and vessels, fibronectin is present as an insoluble protein that is extensively cross-linked by interchain disulfide bonds forming high molecular mass polymers. Fibronectin is most abundant during embryonic development and tissue remodeling. Fibronectin is also present at high concentrations as a soluble plasma protein. Fibronectin is organized as a linear series of repeating modules which form domains for interaction with fibronectin itself, other matrix components (e.g. collagen and heparin) and receptors on cells (e.g. integrins). Fibronectin is present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. Fibronectin has been implicated in carcinoma development in lung cancer. Further, Fibronectin expression is increased especially in non-small cell lung carcinoma. The adhesion of lung carcinoma cells to Fibronectin enhances tumorgenecity and confers resistance to apoptosis induced by standard chemotherapeutic agents. The gene encoding Fibronectin has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some Fibronectin variants has not been determined.
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