Invitrogen

CD8a Monoclonal Antibody (53-6.7), Super Bright™ 436, eBioscience™

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CD8a Antibody (62-0081-82) in Flow

BALB/c mouse splenocytes were stained with CD3 Monoclonal Antibody, FITC (Product # 11-0032) and 0.125 µg of Rat IgG2a kappa Isotype Control, Super Bright 436 (Product # 62-4321) (left) or 0.125 µg of CD8a Monoclonal Antibody, Super Bright 436 (right). Cells in the lymphocyte gate were used for analysis.

CD8a Antibody in Immunohistochemistry (IHC)

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产品信息

62-0081-82

应用

建议稀释比

已发表文章

免疫组化 (IHC)

查看7篇已发表文章 7篇已发表文章

流式细胞分析 (Flow)

0.25 µg/test

查看70篇已发表文章 70篇已发表文章

产品规格

种属反应

Mouse

已发表种属

Mouse

宿主/亚型

Rat / IgG2a, kappa

分类

Monoclonal

类型

Antibody

克隆号

53-6.7

偶联物

Super Bright™ 436 Super Bright™ 436 Super Bright™ 436

激发/发射光谱

413/431 nm 查看光谱

形式

Liquid

浓度

0.2 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.2, with BSA

内含物

0.09% sodium azide

保存条件

4° C, store in dark, DO NOT FREEZE!

运输条件

Ambient (domestic); Wet ice (international)

AB_2716981

产品详细信息

Description: The 53-6.7 monoclonal antibody reacts with the mouse CD8a molecule. CD8a is an approximately 32-34 kDa cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha beta) or as a homodimer (CD8 alpha alpha). A majority of thymocytes and a subpopulation of mature alpha beta TCR T cells express CD8 alpha beta while gamma delta TCR T cells, a subpopulation of intestinal intraepithelial lymphocytes (IELs) and dendritic cells express CD8 alpha alpha. CD8 binds to MHC class I and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells.

Applications Reported: This 53-6.7 antibody has been reported for use in flow cytometric analysis.

Applications Tested: This 53-6.7 antibody has been tested by flow cytometric analysis of mouse splenocytes. This may be used at less than or equal to 0.25 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Super Bright 436 can be excited with the violet laser line (405 nm) and emits at 436 nm. We recommend using a 450/50 bandpass filter, or equivalent. Please make sure that your instrument is capable of detecting this fluorochrome.

When using two or more Super Bright dye-conjugated antibodies in a staining panel, it is recommended to use Super Bright Complete Staining Buffer (Product # SB-4401) to minimize any non-specific polymer interactions. Please refer to the datasheet for Super Bright Staining Buffer for more information.

Excitation: 405 nm; Emission: 436 nm; Laser: Violet Laser

Super Bright Polymer Dyes are sold under license from Becton, Dickinson and Company.

靶标信息

Cluster of differentiation 8 (CD8), a type I transmembrane glycoprotein of the immunoglobulin family of receptors, plays an integral role in signal transduction, and T cell differentiation and activation. CD8 is predominantly expressed on T cells as a disulfide-linked heterodimer of CD8alpha and CD8beta, where it functions as a co-receptor, along with T cell receptor (TCR), for major histocompatibilty complex class I (MHC-I) molecules; whereas its counterpart, CD4, acts as a co-receptor for MHC-II molecules. CD8 exists on the cell surface, where the CD8alpha chain is essential for binding to MHC-I. CD8 is also expressed on a subset of T cells, NK cells, monocytes and dendritic cells as disulfide-linked homodimers of CD8alpha. Ligation of MHC-I/peptide complexes presented by antigen-presenting cells (APCs), triggers the recruitment of lymphocyte-specific protein tyrosine kinase (Lck), which leads to lymphokine production, motility and cytotoxic T lymphocyte (CTL) activation. Once activated, CTLs play a crucial role in the clearance of pathogens and tumor cells. Differentiation of naive CD8+ T cells into CTLs is strongly enhanced by IL-2, IL-12 and TGF-beta1.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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Osteoprotegerin-dependent M cell self-regulation balances gut infection and immunity.

Nature communications

Kimura S,Nakamura Y,Kobayashi N,Shiroguchi K,Kawakami E,Mutoh M,Takahashi-Iwanaga H,Yamada T,Hisamoto M,Nakamura M,Udagawa N,Sato S,Kaisho T,Iwanaga T,Hase K

Published figure using CD8a monoclonal antibody (Product # 62-0081-82) in Flow Cytometry

Mon Jan 13 00:00:00 UTC 2020

Loss of testosterone impairs anti-tumor neutrophil function.

Nature communications

Markman JL,Porritt RA,Wakita D,Lane ME,Martinon D,Noval Rivas M,Luu M,Posadas EM,Crother TR,Arditi M

Published figure using CD8a monoclonal antibody (Product # 62-0081-82) in Flow Cytometry

Tue Mar 31 00:00:00 UTC 2020

Oncolytic vaccinia virus delivering tethered IL-12 enhances antitumor effects with improved safety.

Journal for immunotherapy of cancer

Ge Y,Wang H,Ren J,Liu W,Chen L,Chen H,Ye J,Dai E,Ma C,Ju S,Guo ZS,Liu Z,Bartlett DL

Published figure using CD8a monoclonal antibody (Product # 62-0081-82) in Flow Cytometry

Sun Mar 01 00:00:00 UTC 2020

Specific targeting of IL-1β activity to CD8⁺ T cells allows for safe use as a vaccine adjuvant.

NPJ vaccines

Van Den Eeckhout B,Van Hoecke L,Burg E,Van Lint S,Peelman F,Kley N,Uzé G,Saelens X,Tavernier J,Gerlo S

Published figure using CD8a monoclonal antibody (Product # 62-0081-82) in Flow Cytometry

Tue Sep 19 00:00:00 UTC 2023

ICOS agonism by JTX-2011 (vopratelimab) requires initial T cell priming and Fc cross-linking for optimal T cell activation and anti-tumor immunity in preclinical models.

PloS one

Hanson A,Elpek K,Duong E,Shallberg L,Fan M,Johnson C,Wallace M,Mabry GR,Sazinsky S,Pepper L,Shu CJ,Sathyanarayanan S,Zuerndorfer S,Simpson T,Gostissa M,Briskin M,Law D,Michaelson J,Harvey CJ

Published figure using CD8a monoclonal antibody (Product # 62-0081-82) in Flow Cytometry

Mon Nov 16 00:00:00 UTC 2020

Atherogenesis in the Carotid Artery with and without Interrupted Blood Flow of Two Hyperlipidemic Mouse Strains.

Journal of vascular research

Zhao J,Huangfu C,Chang Z,Grainger AT,Liu Z,Shi W

Published figure using CD8a monoclonal antibody (Product # 62-0081-82) in Flow Cytometry

Mon Jan 27 00:00:00 UTC 2020

Doxorubicin-polyglycerol-nanodiamond conjugate is a cytostatic agent that evades chemoresistance and reverses cancer-induced immunosuppression in triple-negative breast cancer.

Journal of nanobiotechnology

Yuan SJ,Xu YH,Wang C,An HC,Xu HZ,Li K,Komatsu N,Zhao L,Chen X

Published figure using CD8a monoclonal antibody (Product # 62-0081-82) in Flow Cytometry

Thu Oct 17 00:00:00 UTC 2019

Concomitant type I IFN and M-CSF signaling reprograms monocyte differentiation and drives pro-tumoral arginase production.

EBioMedicine

Tong Y,Zhou L,Yang L,Guo P,Cao Y,Qin FX,Liu J

Published figure using CD8a monoclonal antibody (Product # 62-0081-82) in Flow Cytometry

Tue Jan 01 00:00:00 UTC 2019

CD160 serves as a negative regulator of NKT cells in acute hepatic injury.

Nature communications

Kim TJ,Park G,Kim J,Lim SA,Kim J,Im K,Shin MH,Fu YX,Del Rio ML,Rodriguez-Barbosa JI,Yee C,Suh KS,Kim SJ,Ha SJ,Lee KM

Published figure using CD8a monoclonal antibody (Product # 62-0081-82) in Flow Cytometry

Mon Jul 22 00:00:00 UTC 2019

REV-ERBα Regulates T_H17 Cell Development and Autoimmunity.

Cell reports

Amir M,Chaudhari S,Wang R,Campbell S,Mosure SA,Chopp LB,Lu Q,Shang J,Pelletier OB,He Y,Doebelin C,Cameron MD,Kojetin DJ,Kamenecka TM,Solt LA

Published figure using CD8a monoclonal antibody (Product # 62-0081-82) in Flow Cytometry

Wed Dec 26 00:00:00 UTC 2018

A cancer vaccine-mediated postoperative immunotherapy for recurrent and metastatic tumors.

Nature communications

Wang T,Wang D,Yu H,Feng B,Zhou F,Zhang H,Zhou L,Jiao S,Li Y

Published figure using CD8a monoclonal antibody (Product # 62-0081-82) in Flow Cytometry

Wed Apr 18 00:00:00 UTC 2018

Microglia prevent peripheral immune cell invasion and promote an anti-inflammatory environment in the brain of APP-PS1 transgenic mice.

Journal of neuroinflammation

Unger MS,Schernthaner P,Marschallinger J,Mrowetz H,Aigner L

Published figure using CD8a monoclonal antibody (Product # 62-0081-82) in Flow Cytometry

Fri Sep 21 00:00:00 UTC 2018

Nuclear receptor NR2F6 inhibition potentiates responses to PD-L1/PD-1 cancer immune checkpoint blockade.

Nature communications

Klepsch V,Hermann-Kleiter N,Do-Dinh P,Jakic B,Offermann A,Efremova M,Sopper S,Rieder D,Krogsdam A,Gamerith G,Perner S,Tzankov A,Trajanoski Z,Wolf D,Baier G

Published figure using CD8a monoclonal antibody (Product # 62-0081-82) in Flow Cytometry

Wed Apr 18 00:00:00 UTC 2018

Store-Operated Ca²⁺ Entry Controls Clonal Expansion of T Cells through Metabolic Reprogramming.

Immunity

Vaeth M,Maus M,Klein-Hessling S,Freinkman E,Yang J,Eckstein M,Cameron S,Turvey SE,Serfling E,Berberich-Siebelt F,Possemato R,Feske S

Published figure using CD8a monoclonal antibody (Product # 62-0081-82) in Flow Cytometry

Tue Oct 17 00:00:00 UTC 2017

Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease.

Proceedings of the National Academy of Sciences of the United States of America

Pishesha N,Bilate AM,Wibowo MC,Huang NJ,Li Z,Deshycka R,Bousbaine D,Li H,Patterson HC,Dougan SK,Maruyama T,Lodish HF,Ploegh HL

Published figure using CD8a monoclonal antibody (Product # 62-0081-82) in Flow Cytometry

Tue Mar 21 00:00:00 UTC 2017

SOCS3 treatment prevents the development of alopecia areata by inhibiting CD8+ T cell-mediated autoimmune destruction.

Oncotarget

Gao Z,Jin YQ,Wu W

Published figure using CD8a monoclonal antibody (Product # 62-0081-82) in Flow Cytometry

Tue May 16 00:00:00 UTC 2017

Low energy X-ray (grenz ray) treatment of purified islets prior to allotransplant markedly decreases passenger leukocyte populations.

Islets

Pawlick R,Gala-Lopez B,Pepper AR,Abualhassan N,Bruni A,Suzuki K,Rayat G,Elliott JF,Shapiro AMJ

Published figure using CD8a monoclonal antibody (Product # 62-0081-82) in Flow Cytometry

Tue Jul 04 00:00:00 UTC 2017

Interleukin-21 combined with PD-1 or CTLA-4 blockade enhances antitumor immunity in mouse tumor models.

Oncoimmunology

Lewis KE,Selby MJ,Masters G,Valle J,Dito G,Curtis WR,Garcia R,Mink KA,Waggie KS,Holdren MS,Grosso JF,Korman AJ,Jure-Kunkel M,Dillon SR

Published figure using CD8a monoclonal antibody (Product # 62-0081-82) in Flow Cytometry

Tue Jan 12 00:00:00 UTC 2021

Cblb-deficient T cells are less susceptible to PD-L1-mediated inhibition.

Oncotarget

Peer S,Baier G,Gruber T

Published figure using CD8a monoclonal antibody (Product # 62-0081-82) in Flow Cytometry

Tue Jun 27 00:00:00 UTC 2017

Distinct in vitro properties of embryonic and extraembryonic fibroblast-like cells are reflected in their in vivo behavior following grafting in the adult mouse brain.

Cell transplantation

Costa R,Bergwerf I,Santermans E,De Vocht N,Praet J,Daans J,Le Blon D,Hoornaert C,Reekmans K,Hens N,Goossens H,Berneman Z,Parolini O,Alviano F,Ponsaerts P

Published figure using CD8a monoclonal antibody (Product # 62-0081-82) in Flow Cytometry

Mon Nov 16 00:00:00 UTC 2015

P2X7 receptor modulates inflammatory and functional pulmonary changes induced by silica.

PloS one

Monção-Ribeiro LC,Faffe DS,Santana PT,Vieira FS,da Graça CL,Marques-da-Silva C,Machado MN,Caruso-Neves C,Zin WA,Borojevic R,Takiya CM,Coutinho-Silva R

Published figure using CD8a monoclonal antibody (Product # 62-0081-82) in Flow Cytometry

Thu Sep 17 00:00:00 UTC 2015

生物信息学

蛋白别名: CD8a; CD8alpha; CD8b; CD8beta; fCD8; Leu-2; leu-2a; Lymphocyte antigen 3; Lyt-2.1 lymphocyte differentiation antigen (AA at 100); T-cell membrane glycoprotein Ly-3; T-cell surface glycoprotein CD8 alpha chain; T-cell surface glycoprotein CD8 beta chain; T-cell surface glycoprotein Lyt-2; T-cell surface glycoprotein Lyt-3

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基因别名: BB154331; Cd8a; Cd8b; Cd8b1; Ly-2; Ly-3; Ly-35; Ly-B; Ly-C; Lyt-2; Lyt-3; Lyt2; Lyt3

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UniProt ID: (Mouse) P01731, (Mouse) P10300

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Entrez Gene ID: (Mouse) 12525, (Mouse) 12526

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功能

protein binding protein kinase binding protein homodimerization activity defense/immunity protein immunoglobulin receptor superfamily

参与通路

immune system process T cell mediated immunity cell surface receptor signaling pathway T cell activation cytotoxic T cell differentiation positive regulation of calcium-mediated signaling defense response to virus