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产品信息
MA5-15783
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
8F1A7
抗原
Recombinant protein corresponding to amino acids 618 - 712 of human IRAK.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11154024
产品详细信息
A suggested positive control is IRAK recombinant protein.
靶标信息
IL-1 receptor associated kinases (IRAKs) are serine/threonine kinases involved in signaling via Toll/IL-1 pathways. It is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. IRAK's association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Alternatively, IRAK1 can phosphorylate TIRAP to promote its ubiquitination and subsequent degradation. IRAK1 also phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus. This results in the transcriptional activiation of type I IFN genes, which drive the cell in an antiviral state.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Interleukin-1 receptor-associated kinase 1; interleukin-1 receptor-associated kinase-1; IRAK; IRAK-1; mPLK; Pelle homolog; Pelle-like protein kinase
基因别名: AA408924; Il1rak; IRAK; IRAK-1; IRAK1; IRAK1-S; mPLK; pelle; Plpk; RGD1563841
UniProt ID: (Human) P51617, (Mouse) B1AUW4
Entrez Gene ID: (Human) 3654, (Mouse) 16179, (Rat) 363520
protein kinase activity
protein serine/threonine kinase activity
NF-kappaB-inducing kinase activity
protein binding
ATP binding
kinase activity
heat shock protein binding
protein homodimerization activity
protein heterodimerization activity
nucleotide binding
interleukin-1 receptor binding
transferase activity
transferase activity, transferring phosphorus-containing groups
activation of MAPK activity
regulation of cytokine-mediated signaling pathway
toll-like receptor signaling pathway
MyD88-dependent toll-like receptor signaling pathway
protein phosphorylation
signal transduction
transmembrane receptor protein serine/threonine kinase signaling pathway
activation of NF-kappaB-inducing kinase activity
JNK cascade
aging
lipopolysaccharide-mediated signaling pathway
negative regulation of NF-kappaB transcription factor activity
positive regulation of type I interferon production
response to lipopolysaccharide
toll-like receptor 2 signaling pathway
toll-like receptor 4 signaling pathway
toll-like receptor 9 signaling pathway
cellular response to heat
negative regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of MAP kinase activity
innate immune response
positive regulation of transcription, DNA-templated
protein autophosphorylation
positive regulation of smooth muscle cell proliferation
positive regulation of NF-kappaB transcription factor activity
protein oligomerization
nucleotide-binding oligomerization domain containing signaling pathway
interleukin-1-mediated signaling pathway
response to interleukin-1
cellular response to hypoxia
immune system process
phosphorylation
cytokine-mediated signaling pathway
response to peptidoglycan
intracellular signal transduction
positive regulation of JUN kinase activity
negative regulation of transcription, DNA-templated
negative regulation of cholesterol efflux
cellular response to lipopolysaccharide
