Product References
Mechanisms of action of ruxolitinib in murine models of hemophagocytic lymphohistiocytosis.
Blood
Albeituni S,Verbist KC,Tedrick PE,Tillman H,Picarsic J,Bassett R,Nichols KE
MA1-70074 was used in Flow Cytometry to show that ruxolitinib operates through IFN-γ-dependent and -independent mechanisms to dampen HLH by targeting the deleterious effects of T cells and neutrophils, with the latter representing an unappreciated and understudied cell type that contributes to HLH pathogenesis.
Thu Jul 11 00:00:00 UTC 2019
Inhibition of T cell activation and function by the adaptor protein CIN85.
Science signaling
Kong MS,Hashimoto-Tane A,Kawashima Y,Sakuma M,Yokosuka T,Kometani K,Onishi R,Carpino N,Ohara O,Kurosaki T,Phua KK,Saito T
MA1-70074 was used in Flow Cytometry to show that CIN85 (Cbl-interacting protein of 85 kDa) limited T cell responses to T cell receptor stimulation.
Tue Feb 05 00:00:00 UTC 2019
Defective germinal center B-cell response and reduced arthritic pathology in microRNA-29a-deficient mice.
Cellular and molecular life sciences : CMLS
van Nieuwenhuijze A,Dooley J,Humblet-Baron S,Sreenivasan J,Koenders M,Schlenner SM,Linterman M,Liston A
MA170074 was used in flow cytometry to evaluate miR-29a in B cells as a potential therapeutic target in arthritis
Thu Jun 01 00:00:00 UTC 2017
Polymicrobial sepsis impairs bystander recruitment of effector cells to infected skin despite optimal sensing and alarming function of skin resident memory CD8 T cells.
PLoS pathogens
Danahy DB,Anthony SM,Jensen IJ,Hartwig SM,Shan Q,Xue HH,Harty JT,Griffith TS,Badovinac VP
MA1-70074 was used in Flow Cytometry to directly examine the impact of sepsis on tissue resident memory CD8+ T cells in mice.
Fri Sep 01 00:00:00 UTC 2017
NK cells regulate CXCR2+ neutrophil recruitment during acute lung injury.
Journal of leukocyte biology
Hoegl S,Ehrentraut H,Brodsky KS,Victorino F,Golden-Mason L,Eltzschig HK,McNamee EN
MA170074 was used in flow cytometry to elucidate the role of Tbet in acute lung injury
Wed Feb 01 00:00:00 UTC 2017
Impairment of CCR6+ and CXCR3+ Th Cell Migration in HIV-1 Infection Is Rescued by Modulating Actin Polymerization.
Journal of immunology (Baltimore, Md. : 1950)
Cecchinato V,Bernasconi E,Speck RF,Proietti M,Sauermann U,D'Agostino G,Danelon G,Rezzonico Jost T,Grassi F,Raeli L,Schöni-Affolter F,Stahl-Hennig C,Uguccioni M
MA170074 was used in flow cytometry to suggest that persistent immune activation causes impairment of lymphocytes to respond to chemotactic stimuli, preventing their trafficking from the blood stream to peripheral organs
Sun Jan 01 00:00:00 UTC 2017
BAFF-secreting neutrophils drive plasma cell responses during emergency granulopoiesis.
The Journal of experimental medicine
Parsa R,Lund H,Georgoudaki AM,Zhang XM,Ortlieb Guerreiro-Cacais A,Grommisch D,Warnecke A,Croxford AL,Jagodic M,Becher B,Karlsson MC,Harris RA
MA170074 was used in flow cytometry to examine the impact of emergency granulopoiesis on T and B cell function
Mon Jul 25 00:00:00 UTC 2016
lck-Driven Cre Expression Alters T Cell Development in the Thymus and the Frequencies and Functions of Peripheral T Cell Subsets.
Journal of immunology (Baltimore, Md. : 1950)
Carow B,Gao Y,Coquet J,Reilly M,Rottenberg ME
MA170074 was used in flow cytometry to implement lck-cre transgenic mice to study the role of loxP-targeted genes in T cell development and function
Thu Sep 15 00:00:00 UTC 2016
Trypanosoma cruzi Causes Paralyzing Systemic Necrotizing Vasculitis Driven by Pathogen-Specific Type I Immunity in Mice.
Infection and immunity
Roffê E,Marino APMP,Weaver J,Wan W,de Araújo FF,Hoffman V,Santiago HC,Murphy PM
MA170074 was used in flow cytometry to demonstrate that control of acute infection with Trypanosoma cruzi is associated with development of systemic necrotizing vasculitis
Fri Apr 01 00:00:00 UTC 2016
Ndfip-mediated degradation of Jak1 tunes cytokine signalling to limit expansion of CD4+ effector T cells.
Nature communications
O'Leary CE,Riling CR,Spruce LA,Ding H,Kumar S,Deng G,Liu Y,Seeholzer SH,Oliver PM
MA170074 was used in flow cytometry to demonstrate that Ndfip1/Ndfip2 regulate cross talk between T-cell receptor and cytokine signaling pathways
Mon Apr 18 00:00:00 UTC 2016
Myeloid cell expressed proprotein convertase FURIN attenuates inflammation.
Oncotarget
Cordova ZM,Grönholm A,Kytölä V,Taverniti V,Hämäläinen S,Aittomäki S,Niininen W,Junttila I,Ylipää A,Nykter M,Pesu M
MA170074 was used in flow cytometry to investigate the role of FURIN in LysM positive myeloid cells in vivo
Tue Aug 23 00:00:00 UTC 2016
C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation.
Nature communications
Bulla R,Tripodo C,Rami D,Ling GS,Agostinis C,Guarnotta C,Zorzet S,Durigutto P,Botto M,Tedesco F
MA170074 was used in flow cytometry to suggest that locally synthesized C1q promotes tumor growth
Mon Feb 01 00:00:00 UTC 2016
Tumor Progression Locus 2 (Tpl2) Activates the Mammalian Target of Rapamycin (mTOR) Pathway, Inhibits Forkhead Box P3 (FoxP3) Expression, and Limits Regulatory T Cell (Treg) Immunosuppressive Functions.
The Journal of biological chemistry
Li X,Acuff NV,Peeks AR,Kirkland R,Wyatt KD,Nagy T,Watford WT
MA1-70074 was used in Flow Cytometry to demonstrate that the serine/threonine kinase tumour progression locus 2 constrains the development of inducible regulatory T cells.
Fri Aug 05 00:00:00 UTC 2016
Glibenclamide Prevents Diabetes in NOD Mice.
PloS one
Lamprianou S,Gysemans C,Bou Saab J,Pontes H,Mathieu C,Meda P
MA170074 was used in flow cytometry to explore if the anti-diabetic sulphonylurea glibenclamide protects insulin-producing cells against conditions mimicking those expected at the onset of type 1 diabetes
Tue Jul 18 00:00:00 UTC 2017
PI3Kδ Regulates the Magnitude of CD8+ T Cell Responses after Challenge with Listeria monocytogenes.
Journal of immunology (Baltimore, Md. : 1950)
Pearce VQ,Bouabe H,MacQueen AR,Carbonaro V,Okkenhaug K
MA1-70074 was used in flow cytometry to study PI3KΔ in CD8+ T cells during infection with Listeria monocytogenes.
Thu Oct 01 00:00:00 UTC 2015
Regulation of IgE production and airway reactivity by CD4⁻CD8⁻ regulatory T cells.
Immunobiology
Raker V,Stein J,Montermann E,Maxeiner J,Taube C,Reske-Kunz AB,Sudowe S
MA1-70074 was used in flow cytometry to characterize high zone tolerance in mouse models of type I allergy and of allergic airway inflammation.
Wed Apr 01 00:00:00 UTC 2015
Few Foxp3⁺ regulatory T cells are sufficient to protect adult mice from lethal autoimmunity.
European journal of immunology
Mayer CT,Ghorbani P,Kühl AA,Stüve P,Hegemann M,Berod L,Gershwin ME,Sparwasser T
MA1-70074 was used in Flow cytometry/Cell sorting to study the mechanisms underlying why regulatory T cell-depletion fails to cause autoimmunity in adult Depletion of REGulatory T cells mice.
Wed Oct 01 00:00:00 UTC 2014
Microsphere priming facilitates induction of potent therapeutic T-cell immune responses against autochthonous liver cancers.
European journal of immunology
Brinkhoff B,Ostroumov D,Heemcke J,Woller N,Gürlevik E,Manns MP,Longerich T,Zender L,Harty JT,Kubicka S,Kühnel F,Wirth TC
MA1-70074 was used in Flow Cytometry to develop a prime-boost vaccination protocol based on the administration of antigen conjugated to poly-lactic-co-glycolic acid microspheres followed by booster vaccination with Listeria monocytogenes vectors.
Tue Apr 01 00:00:00 UTC 2014
Interferon-γ induces expression of MHC class II on intestinal epithelial cells and protects mice from colitis.
PloS one
Thelemann C,Eren RO,Coutaz M,Brasseit J,Bouzourene H,Rosa M,Duval A,Lavanchy C,Mack V,Mueller C,Reith W,Acha-Orbea H
MA1-70074 was used in Flow Cytometry to investigate how epithelial MHCII expression is induced and how a deficiency in inducible epithelial MHCII expression alters susceptibility to colitis and the outcome of colon-specific immune responses.
Mon Dec 22 00:00:00 UTC 2014
CD70-driven costimulation induces survival or Fas-mediated apoptosis of T cells depending on antigenic load.
Journal of immunology (Baltimore, Md. : 1950)
Wensveen FM,Unger PP,Kragten NA,Derks IA,ten Brinke A,Arens R,van Lier RA,Eldering E,van Gisbergen KP
MA1-70074 was used in Flow Cytometry to investigate how BIm-dependent apoptosis is initiated in CD8 T cells.
Tue May 01 00:00:00 UTC 2012
CD40-activated B cells can efficiently prime antigen-specific naïve CD8+ T cells to generate effector but not memory T cells.
PloS one
Mathieu M,Cotta-Grand N,Daudelin JF,Boulet S,Lapointe R,Labrecque N
MA1-70074 was used in flow cytometry to test the ability of different types of antigen presenting cells to induce a CD8(+) T cell response.
Mon Jun 04 00:00:00 UTC 2012
Accumulation of eosinophils in intestine-draining mesenteric lymph nodes occurs after Trichuris muris infection.
Parasite immunology
Svensson M,Bell L,Little MC,DeSchoolmeester M,Locksley RM,Else KJ
MA1-70074 was used in Flow Cytometry to study the accumulation of eosinophils in intestine-draining mesenteric lymph nodes following Trichuris muris infection.
Sat Jan 01 00:00:00 UTC 2011
Cell-to-cell interactions and signals involved in the reconstitution of peripheral CD8 T(CM) and T(EM) cell pools.
PloS one
Zaragoza B,Evaristo C,Kissenpfennig A,Libri V,Malissen B,Rocha B,Freitas AA,Almeida AR
MA1-70074 was used in flow cytometry to determine the reconstitution capacity of transferred isolated naive CD8+ T cells
Mon Mar 14 00:00:00 UTC 2011
B7-H1-dependent sex-related differences in tumor immunity and immunotherapy responses.
Journal of immunology (Baltimore, Md. : 1950)
Lin PY,Sun L,Thibodeaux SR,Ludwig SM,Vadlamudi RK,Hurez VJ,Bahar R,Kious MJ,Livi CB,Wall SR,Chen L,Zhang B,Shin T,Curiel TJ
MA1-70074 was used in flow cytometry to report sex-dependent, B7-H1-dependent differences in tumor immunity
Wed Sep 01 00:00:00 UTC 2010
Kinetic assessment and therapeutic modulation of metabolic and inflammatory profiles in mice on a high-fat and cholesterol diet.
PPAR research
Engstrom LW,Bober L,Chen SC,Fine JS,Li Y,Stanton MC,Kinsley D,Cui L,Jackson JV,Rojas-Triana A,Lundell D,Laverty M,Gustafson EL,Jenh CH,Kowalski TJ,Manfra DJ
MA1-70074 was used in flow cytometry to use a murine diet-induced obesity model to study the kinetics of metabolic and inflammatory factors
Thu Jul 14 00:00:00 UTC 2011
AUF1 is involved in splenic follicular B cell maintenance.
BMC immunology
Sadri N,Lu JY,Badura ML,Schneider RJ
MA1-70074 was used in flow cytometry to elucidate the role of AUF1 in the immune system
Mon Jan 11 00:00:00 UTC 2010
Ly49D engagement on T lymphocytes induces TCR-independent activation and CD8 effector functions that control tumor growth.
Journal of immunology (Baltimore, Md. : 1950)
Merck E,Voyle RB,MacDonald HR
MA1-70074 was used in flow cytometry to report that Ly49D engagement on T cells leads to T cell activation and TCR-independent effector functions of CD8 T cells
Thu Jan 01 00:00:00 UTC 2009
Accumulation of effector CD4 T cells during type 2 immune responses is negatively regulated by Stat6.
Journal of immunology (Baltimore, Md. : 1950)
King SB,Knorn AM,Ohnmacht C,Voehringer D
MA1-70074 was used in flow cytometry to investigate the effect of Stat6 in T cell expansion, survival, and recruitment to the lung
Tue Jan 15 00:00:00 UTC 2008
Combined triggering of dendritic cell receptors results in synergistic activation and potent cytotoxic immunity.
Journal of immunology (Baltimore, Md. : 1950)
Wells JW,Cowled CJ,Farzaneh F,Noble A
MA1-70074 was used in flow cytometry to identify key signals required for the exponential expansion of specific CD8 positive mouse T cells in vivo
Mon Sep 01 00:00:00 UTC 2008
Induction of experimental cerebral malaria is independent of TLR2/4/9.
Medical microbiology and immunology
Lepenies B,Cramer JP,Burchard GD,Wagner H,Kirschning CJ,Jacobs T
MA1-70074 was used in flow cytometry to demonstrate that cerebral malaria development is independent of TLR2, 4 and 9
Sat Mar 01 00:00:00 UTC 2008
Overexpression of IL-21 promotes massive CD8+ memory T cell accumulation.
European journal of immunology
Allard EL,Hardy MP,Leignadier J,Marquis M,Rooney J,Lehoux D,Labrecque N
MA1-70074 was used in flow cytometry to test the influences of IL-21 on cytokine receptor expression
Thu Nov 01 00:00:00 UTC 2007
Distinct subsets of FoxP3+ regulatory T cells participate in the control of immune responses.
Journal of immunology (Baltimore, Md. : 1950)
Stephens GL,Andersson J,Shevach EM
MA1-70074 was used in flow cytometry to discuss the development and functions of effector and memory Foxp3+ T cells
Fri Jun 01 00:00:00 UTC 2007
Unique ability of activated CD4+ T cells but not rested effectors to migrate to non-lymphoid sites in the absence of inflammation.
The Journal of biological chemistry
Agrewala JN,Brown DM,Lepak NM,Duso D,Huston G,Swain SL
MA1-70074 was used in flow cytometry to study the migration and persistence of naive, effector, and rested effector CD4+ T cells generated in vitro following transfer to nonimmunized adoptive hosts
Fri Mar 02 00:00:00 UTC 2007
Altered CD45 expression in C77G carriers influences immune function and outcome of hepatitis C infection.
Journal of medical genetics
Dawes R,Hennig B,Irving W,Petrova S,Boxall S,Ward V,Wallace D,Macallan DC,Thursz M,Hill A,Bodmer W,Beverley PC,Tchilian EZ
MA1-70074 was used in flow cytometry to discuss how a polymorphism in exon 4 of CD45 contributes to autoimmune and infectious diseases in humans
Tue Aug 01 00:00:00 UTC 2006
FTY720 preferentially depletes naive T cells from peripheral and lymphoid organs.
International immunopharmacology
Hofmann M,Brinkmann V,Zerwes HG
MA1-70074 was used in flow cytometry to assess how FTY720-treatment affects T cell populations
Wed Dec 20 00:00:00 UTC 2006
Identification of organ-specific T cell populations by analysis of multiparameter flow cytometry data using DNA-chip analysis software.
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Hofmann M,Zerwes HG
MA1-70074 was used in flow cytometry to demonstrate that software designed for transcriptomics applications can be used in multiparameter flow cytometry
Thu Jun 01 00:00:00 UTC 2006
Defective CD4+CD25+ regulatory T cell functioning in collagen-induced arthritis: an important factor in pathogenesis, counter-regulated by endogenous IFN-gamma.
Arthritis research & therapy
Kelchtermans H,De Klerck B,Mitera T,Van Balen M,Bullens D,Billiau A,Leclercq G,Matthys P
MA1-70074 was used in flow cytometry to show that the decrease in T regulatory cell activity in collagen-induced arthritis is counter-regulated by endogenous IFN-gamma
Thu Dec 15 00:00:00 UTC 2005
IgE enhances antibody and T cell responses in vivo via CD23+ B cells.
Journal of immunology (Baltimore, Md. : 1950)
Getahun A,Hjelm F,Heyman B
MA1-70074 was used in flow cytometry to test if IgE antibodies modulate T helper cells in vivo
Mon Aug 01 00:00:00 UTC 2005
Hematopoietic stem cell dose correlates with the speed of immune reconstitution after stem cell transplantation.
Blood
Chen BJ,Cui X,Sempowski GD,Domen J,Chao NJ
MA1-70074 was used in flow cytometry to test if higher numbers of hematopoietic stem cells correlate with the speed of immune reconstitution in a congenic transplantation mouse model
Tue Jun 01 00:00:00 UTC 2004
CD4+ T cells prevent skin autoimmunity during chronic autologous graft-versus-host-disease.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Hequet O,Vocanson M,Saint-Mézard P,Kaiserlian D,Nicolas JF,Bérard F
MA1-70074 was used in flow cytometry to test if CD4 regulatory cells prevent autologous graft-vs.-host disease
Tue Jun 01 00:00:00 UTC 2004
Mycobacterial dissemination and cellular responses after 1-lobe restricted tuberculosis infection of genetically susceptible and resistant mice.
The Journal of infectious diseases
Mischenko VV,Kapina MA,Eruslanov EB,Kondratieva EV,Lyadova IV,Young DB,Apt AS
MA1-70074 was used in flow cytometry to study mycobacterial dissemination and immune-cell trafficking in tuberculosis
Wed Dec 15 00:00:00 UTC 2004
Altered CD45 isoform expression affects lymphocyte function in CD45 Tg mice.
International immunology
Tchilian EZ,Dawes R,Hyland L,Montoya M,Le Bon A,Borrow P,Hou S,Tough D,Beverley PC
MA1-70074 was used in flow cytometry to characterize transgenic mice that express the high and low molecular weight CD45 isoforms
Wed Sep 01 00:00:00 UTC 2004
The Trypanosoma cruzi membrane mucin AgC10 inhibits T cell activation and IL-2 transcription through L-selectin.
International immunology
Alcaide P,Fresno M
MA1-70074 was used in flow cytometry to investigate how Trypanosoma cruzi infection results in T cell unresponsiveness
Fri Oct 01 00:00:00 UTC 2004
CD8+ immunoregulatory cells in the graft-versus-host reaction: CD8 T cells activate dendritic cells to secrete interleukin-12/interleukin-18 and induce T helper 1 autoantibody.
Immunology
Noble A,Leggat JA,Inderberg EM
MA1-70074 was used in flow cytometry to examine interactions between alloreactive CD4 and CD8 T cells in mixed lymphocyte reactions and in the graft-versus-host reaction.
Fri Aug 01 00:00:00 UTC 2003
Deregulated MHC class II transactivator expression leads to a strong Th2 bias in CD4+ T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950)
Otten LA,Tacchini-Cottier F,Lohoff M,Annunziato F,Cosmi L,Scarpellino L,Louis J,Steimle V,Reith W,Acha-Orbea H
MA1-70074 was used in flow cytometry to investigate the role of MHC class II transactivator in T cell differentiation.
Sat Feb 01 00:00:00 UTC 2003
A transgenic mouse model genetically tags all activated CD8 T cells.
Journal of immunology (Baltimore, Md. : 1950)
Maris CH,Miller JD,Altman JD,Jacob J
MA1-70074 was used in flow cytometry to track the dynamics of the antiviral CD8+ T cell responses using a transgenic mouse that marks activated T cells.
Mon Sep 01 00:00:00 UTC 2003
Retinoic acid enhances the T helper 2 cell development that is essential for robust antibody responses through its action on antigen-presenting cells.
The Journal of nutrition
Hoag KA,Nashold FE,Goverman J,Hayes CE
MA1-70074 was used in flow cytometry to investigate how all-trans retinoic acid enhances Th2 development.
Sun Dec 01 00:00:00 UTC 2002
CD8+ tumor-infiltrating lymphocytes are primed for Fas-mediated activation-induced cell death but are not apoptotic in situ.
Journal of immunology (Baltimore, Md. : 1950)
Radoja S,Saio M,Frey AB
MA1-70074 was used in flow cytometry to characterize murine tumor-infiltrating lymphocytes.
Tue May 15 00:00:00 UTC 2001
FADD-deficient T cells exhibit a disaccord in regulation of the cell cycle machinery.
The Journal of biological chemistry
Zhang J,Kabra NH,Cado D,Kang C,Winoto A
MA1-70074 was used in flow cytometry to study the cell cycle using FADD(-/-) peripheral T cells.
Fri Aug 10 00:00:00 UTC 2001
Activation of MHC class I, II, and CD40 gene expression by histone deacetylase inhibitors.
Journal of immunology (Baltimore, Md. : 1950)
Magner WJ,Kazim AL,Stewart C,Romano MA,Catalano G,Grande C,Keiser N,Santaniello F,Tomasi TB
MA1-70074 was used in flow cytometry to report that histone deacetylase inhibitors alter the acetylation of histones and enhance the expression of several genes on tumor cells.
Fri Dec 15 00:00:00 UTC 2000
Induction of Th2 cell differentiation in the primary immune response: dendritic cells isolated from adherent cell culture treated with IL-10 prime naive CD4+ T cells to secrete IL-4.
International immunology
Liu L,Rich BE,Inobe J,Chen W,Weiner HL
MA1-70074 was used in flow cytometry to identify the initial source of IL-4 in early immune responses.
Sat Aug 01 00:00:00 UTC 1998
Sequential contribution of L- and P-selectin to leukocyte rolling in vivo.
The Journal of experimental medicine
Ley K,Bullard DC,Arbonés ML,Bosse R,Vestweber D,Tedder TF,Beaudet AL
MA1-70074 was used in blocking or activating experiment to observe leukocyte rolling after tissue trauma
Wed Feb 01 00:00:00 UTC 1995
Lack of L-selectin expression by cells transferring diabetes in NOD mice: insights into the mechanisms involved in diabetes prevention by Mel-14 antibody treatment.
European journal of immunology
Lepault F,Gagnerault MC,Faveeuw C,Bazin H,Boitard C
MA1-70074 was used in blocking assay and flow cytometry to assess the role of L-selectin in the pathogenesis of autoimmune diabetes.
Thu Jun 01 00:00:00 UTC 1995
A pertussis toxin-sensitive process controls thymocyte emigration.
European journal of immunology
Chaffin KE,Perlmutter RM
MA1-70074 was used in flow cytometry to investigate thymocyte emigration.
Tue Oct 01 00:00:00 UTC 1991
The mouse lymph node homing receptor is identical with the lymphocyte cell surface marker Ly-22: role of the EGF domain in endothelial binding.
Cell
Siegelman MH,Cheng IC,Weissman IL,Wakeland EK
MA1-70074 was used in blocking or activating experiment, flow cytometry, and immunoprecipitation to study localization of lymph node homing receptor core polypeptide to Chromosome 1
Fri May 18 00:00:00 UTC 1990
Leukocyte-endothelial cell recognition: evidence of a common molecular mechanism shared by neutrophils, lymphocytes, and other leukocytes.
Journal of immunology (Baltimore, Md. : 1950)
Lewinsohn DM,Bargatze RF,Butcher EC
MA1-70074 was used in flow cytometry to show the involvement of the MEL-14 antigen in neutrophil-endothelial cell interactions
Mon Jun 15 00:00:00 UTC 1987
