Invitrogen

CD62L Monoclonal Antibody (MEL-14), Biotin

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CD62L Antibody (MA5-17799) in Flow

Flow cytometric analysis of Lymphe Node cells stained using anti-CD62L/L-selectin Monoclonal Antibody (Product # MA5-17799) at a 0.2 µg/10^6 cells dilution. The Isotype control was a Biotin Rat IgG2a

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产品信息

MA5-17799

应用

建议稀释比

已发表文章

免疫组化（冰冻） (IHC (F))

Assay-dependent

流式细胞分析 (Flow)

0.2 µg/1x10^6 cells

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酶联免疫吸附实验 (ELISA)

Assay-dependent

其他PubMed (Misc)

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产品规格

种属反应

Mouse

已发表种属

Mouse

宿主/亚型

Rat / IgG2a

分类

Monoclonal

类型

Antibody

克隆号

MEL-14

抗原

Mouse B cell Lymphoma, 38C-14

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偶联物

Biotin Biotin Biotin

形式

Liquid

浓度

0.1 mg/mL

纯化类型

Protein G

保存液

PBS with 4-5mg/mL BSA

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_2539183

靶标信息

The human CD62L is a 74-95 kDa glycoprotein member of the selectin family of adhesion receptors. L-Selectin is comprised of an aminoterminal C-type lectin binding domain, an epidermal growth factor-like domain, two short consensus repeat (SCR) sequences homologous to those found in complement binding proteins, a short spacer region, a transmembrane region and a short cytoplasmic region. Human CD62L (L-Selectin) is constitutively expressed on all classes of leukocytes including lymphocytes (except a substantial population of memory T cells), monocytes and polymorphonuclear cells.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Accumulation of effector CD4 T cells during type 2 immune responses is negatively regulated by Stat6.

Journal of immunology (Baltimore, Md. : 1950)

King SB,Knorn AM,Ohnmacht C,Voehringer D

MA5-17799 was used in flow cytometry to investigate the effect of Stat6 in T cell expansion, survival, and recruitment to the lung

Tue Jan 15 00:00:00 UTC 2008

Unique ability of activated CD4+ T cells but not rested effectors to migrate to non-lymphoid sites in the absence of inflammation.

The Journal of biological chemistry

Agrewala JN,Brown DM,Lepak NM,Duso D,Huston G,Swain SL

MA5-17799 was used in flow cytometry to study the migration and persistence of naive, effector, and rested effector CD4+ T cells generated in vitro following transfer to nonimmunized adoptive hosts

Fri Mar 02 00:00:00 UTC 2007

Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation.

Nature immunology

van Stipdonk MJ,Lemmens EE,Schoenberger SP

MA5-17799 was used in flow cytometry to determine the signaling duration requirements for priming and clonal expansion of naive cytotoxic T lymphocytes.

Tue May 01 00:00:00 UTC 2001

Class I MHC molecules on hematopoietic cells can support intrathymic positive selection of T cell receptor transgenic T cells.

Proceedings of the National Academy of Sciences of the United States of America

Zerrahn J,Volkmann A,Coles MC,Held W,Lemonnier FA,Raulet DH

MA5-17799 was used in flow cytometry to identify cells that mediate positive selection of CD8(+) T cells.

Tue Sep 28 00:00:00 UTC 1999

Regulation of T cell immunity and tolerance in vivo by CD4.

International immunology

Shen X,König R

MA5-17799 was used in flow cytometry to test if peptide IAbeta134-148 inhibits antigen-induced T cell tolerance.

Sun Mar 01 00:00:00 UTC 1998

Leukocyte-endothelial cell recognition: evidence of a common molecular mechanism shared by neutrophils, lymphocytes, and other leukocytes.

Journal of immunology (Baltimore, Md. : 1950)

Lewinsohn DM,Bargatze RF,Butcher EC

MA5-17799 was used in flow cytometry to show the involvement of the MEL-14 antigen in neutrophil-endothelial cell interactions

Mon Jun 15 00:00:00 UTC 1987

生物信息学

蛋白别名: CD62 antigen-like family member L; CD62L; hLHRc; L-selectin; LAM-1; LECAM1; Leu-8; Leukocyte adhesion molecule 1; Leukocyte-endothelial cell adhesion molecule 1; Ly-22; Lymph node homing receptor; Lymphocyte antigen 22; Lymphocyte surface MEL-14 antigen

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基因别名: AI528707; CD62L; L-selectin; LECAM-1; Lnhr; Ly-22; Ly-m22; Ly22; Lyam-1; Lyam1; Sell

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UniProt ID: (Mouse) P18337

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Entrez Gene ID: (Mouse) 20343

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功能

protease binding protein binding carbohydrate binding cell adhesion molecule binding glycolipid binding

参与通路

cell adhesion response to ATP regulation of apoptotic process positive regulation of neutrophil chemotaxis