Invitrogen

CD105 Monoclonal Antibody (MEM-226), Alexa Fluor™ 488

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查看其他84个CD105 (Endoglin)抗体

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CD105 Antibody in Flow Cytometry (Flow)

CD105 Antibody in Flow Cytometry (Flow)

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CD105 Antibody (MA5-18120) in Flow

Flow cytometry analysis (surface staining) of HUVEC (human umbilical vein endothelial cells) and HEK-293 cells with anti-CD105 (MEM-226) Alexa Fluor® 488 Monoclonal antibody (Product # MA5-18120).

CD105 Antibody in Flow Cytometry (Flow)

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CD105 Antibody in Flow Cytometry (Flow) — Flow cytometry analysis (surface staining) of HUVEC (human umbilical vein endothelial cells) and HEK-293 cells with anti-CD105 (MEM-226) Alexa Fluor® 488 Monoclonal antibody (Product # MA5-18120).

产品信息

MA5-18120

应用

建议稀释比

已发表文章

免疫印迹 (WB)

Assay-dependent

-

流式细胞分析 (Flow)

4 µL / 100 µL whole blood or 10^6 cells

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产品规格

种属反应

Human, Rat

已发表种属

Rat

宿主/亚型

Mouse / IgG2a

分类

Monoclonal

类型

Antibody

克隆号

MEM-226

抗原

Recombinant Vaccinia virus containing the human CD105 cDNA

偶联物

Alexa Fluor™ 488 Alexa Fluor™ 488 Alexa Fluor™ 488

激发/发射光谱

499/520 nm 查看光谱

形式

Liquid

纯化类型

Size-exclusion chromatography

保存液

PBS with 0.2% BSA

内含物

15mM sodium azide

保存条件

4° C, store in dark, DO NOT FREEZE!

运输条件

Ambient (domestic); Wet ice (international)

AB_2539494

产品详细信息

This antibody reacts with an extracellular epitope of CD105 (Endoglin), a 90 kDa type I homodimerizing membrane glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow; it is also present on syncytiotrophoblast on placenta throughout pregnancy.

靶标信息

CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

How to use the Panel Builder

Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.

Product References

Pharmaceutical Activation of Nrf2 Accelerates Diabetic Wound Healing by Exosomes from Bone Marrow Mesenchymal Stem Cells.

International journal of stem cells

Wang L,Cai Y,Zhang Q,Zhang Y

MA5-18120 was used in Flow cytometry/Cell sorting to evaluate the effects of exosomes from bone marrow-derived mesenchymal stem cells (BMSCs) alone, or in combination with a small molecule activator of nuclear factor erythroid 2-related factor 2 on diabetic wound healing.

Mon May 30 00:00:00 UTC 2022

生物信息学

蛋白别名: CD105; CD105 antigen; Endoglin; ORW

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基因别名: END; ENG; HHT1; ORW1

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UniProt ID: (Human) P17813

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Entrez Gene ID: (Human) 2022, (Rat) 497010

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transmembrane signaling receptor activity transforming growth factor beta receptor, cytoplasmic mediator activity type II transforming growth factor beta receptor binding protein binding galactose binding glycosaminoglycan binding type I transforming growth factor beta receptor binding BMP binding protein homodimerization activity activin binding transforming growth factor beta binding transforming growth factor beta-activated receptor activity transmembrane signal receptor

chronological cell aging patterning of blood vessels vasculogenesis positive regulation of protein phosphorylation heart looping sprouting angiogenesis endocardial cushion morphogenesis cardiac ventricle morphogenesis cardiac atrium morphogenesis ventricular trabecula myocardium morphogenesis cell migration involved in endocardial cushion formation regulation of transcription, DNA-templated cell adhesion negative regulation of gene expression positive regulation of pathway-restricted SMAD protein phosphorylation regulation of transforming growth factor beta receptor signaling pathway central nervous system vasculogenesis negative regulation of cell migration BMP signaling pathway positive regulation of BMP signaling pathway negative regulation of protein autophosphorylation dorsal aorta morphogenesis positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter smooth muscle tissue development artery morphogenesis venous blood vessel morphogenesis endocardial cushion to mesenchymal transition positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation negative regulation of transcription from RNA polymerase II promoter angiogenesis response to hypoxia negative regulation of endothelial cell proliferation positive regulation of systemic arterial blood pressure transmembrane receptor protein serine/threonine kinase signaling pathway transforming growth factor beta receptor signaling pathway heart development positive regulation of gene expression cell migration extracellular matrix disassembly response to corticosteroid positive regulation of collagen biosynthetic process intracellular signal transduction response to statin wound healing cell motility negative regulation of nitric-oxide synthase activity cell chemotaxis bone development negative regulation of pathway-restricted SMAD protein phosphorylation extracellular matrix constituent secretion detection of hypoxia cellular response to mechanical stimulus response to transforming growth factor beta