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SLUG Antibody (PA5-85478) in IHC (P)
SLUG Polyclonal Antibody detects SLUG protein at nucleus on mouse middle brain by immunohistochemical analysis. Sample: Paraffin-embedded mouse middle brain. SLUG Polyclonal Antibody (Product # PA5-85478) dilution: 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
产品信息
PA5-85478
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the center region of human SLUG.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2792618
产品详细信息
Keep as concentrated solution.
Predicted reactivity: Mouse (100%), Rat (99%), Zebrafish (93%), Xenopus laevis (97%), Dog (100%), Pig (97%), Sheep (95%), Rhesus Monkey (100%), Bovine (96%).
Positive Control: human SNAI2-transfected 293T cells.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
Slug, a member of the Snail family of C2H2-type zinc finger transcription factors, was initially identified to be involved in epithelial-mesenchymal transitions as well as the formation of the neural tube during vertebrate embryogenesis. Like Snail, Slug transcription can be induced by growth factors such as FGF, BMP, and TGF-beta. Once expressed, Slug will bind E-box regions of promoters and repress transcription of genes such as E-cadherin and Claudin-1. More recently, its expression in breast, esophogeal, and colorectal carcinomas has been correlated with poor prognosis for survival. Furthermore, Slug can protect hemopoietic progenitor cells from radiation-induced apoptosis by repressing the p53-mediated transcription of Puma, a BH3-only antagonist of the anti-apoptotic members of the Bcl-2 family.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: MGC10182; Neural crest transcription factor Slug; Protein snail homolog 2; slug (chicken homolog), zinc finger protein; slug, chicken homolog; snail family zinc finger 2; snail homolog 2; Zinc finger protein SNAI2
基因别名: SLUG; SLUGH; SLUGH1; SNAI2; SNAIL2; WS2D
UniProt ID: (Human) O43623, (Mouse) P97469
Entrez Gene ID: (Human) 6591, (Mouse) 20583
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
chromatin binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
protein binding
sequence-specific DNA binding
metal ion binding
nucleic acid binding
DNA binding
transcription factor activity, sequence-specific DNA binding
C2H2 zinc finger transcription factor
negative regulation of transcription from RNA polymerase II promoter
osteoblast differentiation
epithelial to mesenchymal transition
epithelial to mesenchymal transition involved in endocardial cushion formation
cell migration involved in endocardial cushion formation
transcription, DNA-templated
negative regulation of cell adhesion involved in substrate-bound cell migration
Notch signaling pathway
sensory perception of sound
negative regulation of keratinocyte proliferation
negative regulation of vitamin D biosynthetic process
neural crest cell development
positive regulation of cell migration
negative regulation of chondrocyte differentiation
regulation of chemokine production
negative regulation of cell adhesion mediated by integrin
positive regulation of histone acetylation
negative regulation of catenin import into nucleus
desmosome disassembly
pigmentation
negative regulation of DNA damage response, signal transduction by p53 class mediator
cellular response to fibroblast growth factor stimulus
positive regulation of fat cell differentiation
regulation of osteoblast differentiation
white fat cell differentiation
palate development
canonical Wnt signaling pathway
epithelium development
cartilage morphogenesis
regulation of branching involved in salivary gland morphogenesis
negative regulation of vitamin D receptor signaling pathway
cellular response to epidermal growth factor stimulus
cellular response to ionizing radiation
negative regulation of canonical Wnt signaling pathway
negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoter
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
negative regulation of stem cell proliferation
regulation of bicellular tight junction assembly
negative regulation of anoikis
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
multicellular organism development
response to radiation
cell migration
cellular response to platelet-derived growth factor stimulus
regulation of apoptotic process
negative regulation of apoptotic process
wound healing, spreading of cells
positive regulation of endothelial cell chemotaxis
