Orbitrap Tribrid Mass Spectrometers

Go beyond with Orbitrap Tribrid MS for large and small molecule analysis

Thermo Scientific Orbitrap Tribrid mass spectrometers enable high throughput analyses of challenging samples. Built on revolutionary Thermo Scientific Tribrid architecture, they combine the best of quadrupole, Orbitrap, and linear ion trap mass analyzers.

Go beyond with accurate and precise quantitation of low-abundance peptides in complex matrices, characterization of structural isomers, from drug metabolites to intact proteins, resolution of isobaric species, and native protein complexes structure characterization.

Which Orbitrap Tribrid MS is right for you?

	Orbitrap Ascend Tribrid MS	Orbitrap Eclipse Tribrid MS	Orbitrap IQ-X Tribrid MS
	Ultimate experimental throughput, versatility, and ease-of-use in multiomics, structural biology, and biopharma applications.	Ideally suited for proteomics, structural biology, small-molecule, and biopharmaceutical characterization experiments.	Reveal complex chemical structures for compound identification and structure elucidation of small molecules.
Applications	Multi-omics, TMT, intact/top-down proteomics, targeted quantification, structural biology, ligand binding, biotherapeutics, fusion proteins, and new modalities.	Multi-omics, TMT, intact top-down proteomics, targeted quantification, crosslinking, biotherapeutics.	Metabolomics, lipidomics, drug development Met ID, extractables and leachables, industrial environmental health and more.
Ease-of-use	Auto-ready calibration source Scheduled remote calibration One click button calibration	One click button calibration	Auto-ready calibration source Scheduled remote calibration One click button calibration
Orbitrap mass range (m/z)	40-6,000 (16,000 with Native MS)	40-6,000 (8,000 with HMR)	40-2,000
Advanced workflows	SQUAD, AcquireX, TMT and TMTpro (up to 32plex), TurboTMT, RTS/RTLS, APD, DIA-PTCR	SQUAD, AcquireX, TMT and TMTpro (up to 32plex), TurboTMT, RTS/RTLS, APD, DIA-PTCR	SQUAD, AcquireX, RTS/RTLS
Optional add-ons	IC/ETD/PTCR/UVPD/Native MS	IC/ETD/PTCR/UVPD/HMR	IC/UVPD

Applications

Proteomics

Orbitrap Tribrid mass spectrometers are the ultimate tool for high accuracy quantitation and deep characterization. Explore individual proteoform-level functionality in complex biological systems.

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Metabolomics and lipidomics

Get deeper analysis into the metabolome by combining discovery and targeted methods. Characterize small molecules and lipids with intelligent acquisitions & unique fragmentation options.

Discover metabolomics and lipidomics solutions

Structural biology

Determine biological functions with Orbitrap Tribrid MS, the complete package for characterization of protein-complexes. Handle experiments from peptides up to ligand binding with native complexes.

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Biopharmaceuticals

Keep pace with biopharmaceutical advances, from fusion proteins to oligonucleotides to MetID. The diversity of needs lends to the versatility of the Orbitrap Tribrid MS.

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System architecture that enables multiple applications

Orbitrap Tribrid mass spectrometer architecture enables experimental flexibility and high performance. With three mass analyzers, the Quadrupole, the Orbitrap, the duel linear ion traps, as well as the Orbitrap and ion trap, which provide two detectors, enable unique methodologies and parallelization within experiments.

The new standard in ease-of-use LCs for all flows

For researchers pursuing the next scientific breakthrough, Thermo Scientific Vanquish UHPLC systems deliver maximum performance 24/7 for reproducible nano-, capillary-, and/or micro-flow LC-MS. Combine the Vanquish Horizon, Duo, or Flex with your Biopharma applications, or use the new Vanquish Neo in nano or capillary flow for your multiomics or structural biology experiments.

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We’ve got a column for that!

Solve your chromatography challenges with our extensive portfolio of HPLC and UHPLC columns. Bringing you a 40-year legacy of innovation, Thermo Scientific (U)HPLC columns offer an unmatched variety of chemistries, from C18 phases, to innovative mixed-mode chemistries, to the broadest range of solid core columns on the market, and more.

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Ion mobility

The Thermo Scientific FAIMS Pro Duo interface extends differential ion mobility capability to multiple Thermo Scientific next-generation mass spectrometers, overcoming sample complexity and matrix interferences delivering increased productivity and data quality.

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Connect projects, people, and instruments on a global level

Designed to support your digital transformation journey, the Thermo Scientific Ardia Platform is a scalable software solution for modern, dynamic (often cloud-based) environments. It connects and organizes projects, people, and instruments, on a global level, with web-based access and secure centralized data storage, enabling scientists to collaborate more efficiently and gain new insights faster, helping them get closer to the truth.

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Services

Scalable service and support plan options

Discover flexible solutions to meet your specific service and support needs, from plans for single instruments to one that is customized to your entire lab or enterprise.

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