DynaDrive Single-Use Bioreactor

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Designed for easy scalability and trusted performance

Reimagine scalability and performance with the Thermo Scientific DynaDrive Single-Use Bioreactor (S.U.B.) which offers exceptional productivity and automation, available from 5 L to 5,000 L. The DynaDrive S.U.B. can decrease the cost of production by up to 25% through a reduction in equipment, materials, consumables, and labor going far beyond the limits of legacy single-use bioreactor systems with greater performance and scalability. Experience an innovative impeller and vessel design, outstanding turndown ratio and reliable, high-quality bioreactor bags. The DynaDrive S.U.B. supports robust production across scales and has the flexibility to accommodate a variety of cell lines and processing modalities.

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DynaDrive Bioreactor performance

The DynaDrive bioreactor brings an exceptional level of performance to single-use bioprocessing.

 

  • Up to 190% increased oxygen mass transfer*—the DynaDrive drilled hole sparge (DHS) is enhanced and specifically designed to optimize the kLa performance. The laser-cut holes in the DHS are smaller, and the quantity has been increased so that bubble size is uniform and sized properly for O2 delivery and CO2 stripping.
  • 41% lower cost per gram**—leveraging higher in-vessel turndown ratios to run multiple stages in a single vessel, reducing the number of BPCs loaded and unloaded, as well as the number of vessels needed in the overall facility.
  • Up to 50% more product with the same footprint†—the flexible drive train includes multiple impellers that enable more PIV while still maintaining reasonable RPM and tip speeds. 
* Compared to legacy S.U.B. designs.

** Based on internal data comparing 5,000 L DynaDrive S.U.B. to legacy S.U.B.

† Comparing 3,000 L DynaDrive S.U.B. to 2,000 L S.U.B.

DynaDrive Bioreactor size and scalability

Available from 5 L to 5,000 L, the DynaDrive Single-Use Bioreactor is the first 5,000 L S.U.B. on the market—now used worldwide.

 

Mass transfer and mixing allows for the use of the same technology over a larger range of facility networks, thus simplifying process transfers. This flexibility provides consistency from research and development to manufacturing phases. 

Minimize risk with Thermo Scientific BioProcess Containers (BPCs)

The DynaDrive BPCs or bioreactor bags offer superior reliability and biocompatibility, backed by decades of experience with featuring BioTitan Retention device.

Features:

  • 0.01% leak rate for minimized risk of product loss*
  • Drilled-hole sparge specifically designed to optimize kLa performance
  • Preinstalled impeller reduces setup time
  • Demonstrated biocompatibility and low cytotoxicity to support healthy cell growth
  • Innovative drive train for impressive power input per volume and improved mixing times while delivering minimal shear
  • Low leachable and extractable profiles to support end-product purity and quality
  • Available with our proprietary Thermo Scientific Aegis5-14 film 

* Overall complaint rate, leakage bag seam or connection, as of March 2023 based on the prior 3 years

Interested in sustainability in bioprocessing? Enjoy the same robust film but now with carbon reduction. Learn more about Thermo Scientific Sustainable film.

Bioreactor controller and software

One standard control and automation platform, scalable and streamlined data flow from clinical through production phases, with digital scaling tools and robust data packages with integrated hardware and an automation solution: Thermo Scientific TruBio Bioprocess Control Software powered by the Emerson DeltaV Live. 

 

The DynaDrive S.U.B. automation system integrates with the Thermo Scientific TruBio software, powered by the DeltaV Live Platform and the Thermo Scientific HyPerforma bioprocess controllers to offer easy, unified data aggregation and quality control, helping to improve the user experience.

Bioreactor application expertise


With 25 years of single-use technology experience, the DynaDrive S.U.B. is our latest advancement in our line of elegantly designed, highly functional single-use bioreactor hardware. It is designed to:

  • Support 21 CFR 820 cGMP requirements
  • Reduce hold-up volumes with a strategically designed tank floor
  • Allow simple BPC loading with vertical access door on all sizes

The doors have been carefully designed so all probe ports and tubing line sets are positioned correctly and easily without the need to be put through constrained holes.

 

Additionally, the DynaDrive S.U.B. tank has a minimized vessel footprint with efficiently sized hardware and offers easy cleaning capabilities associated with an open-cart frame.

DynaDrive Single-Use Bioreactor literature

Brochure: DynaDrive Single-Use Bioreactor (S.U.B.)—dynamic cell culture performance with right-sizing flexibility

Application note: Scale-up evaluation of the DynaDrive S.U.B.s—Part 1: ExpiCHO-S Cells and CHO-S Cells (cGMP banked)

Application note: Scale-up evaluation of the DynaDrive S.U.B.s—Part 2: CHO DG44 and CHO-M

 

Application note: Scale-up evaluation of the DynaDrive S.U.B.s—Part 3: pilot and manufacturing scale comparison of DynaDrive S.U.B. capabilities 

Additional bioprocessing resources

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For Research Use or Further Manufacturing. Not for diagnostic use or direct administration into humans or animals.