Product References
LAMP2 regulates autophagy in the thymic epithelium and thymic stroma-dependent CD4 T cell development.
Autophagy
Rodrigues PM,Sousa LG,Perrod C,Maceiras AR,Ferreirinha P,Pombinho R,Romera-Cárdenas G,Gomez-Lazaro M,Senkara M,Pistolic J,Cabanes D,Klein L,Saftig P,Alves NL
12-5961-82 was used in Flow Cytometry to suggest that LAMP2 interconnects the autophagy-lysosomal axis and the processing of selecting self-peptides:MHC II complexes in cTECs, underling its implications for the generation of a broad CD4 TCR repertoire.
Wed Feb 01 00:00:00 UTC 2023
Tnpo3 controls splicing of the pre-mRNA encoding the canonical TCR α chain of iNKT cells.
Nature communications
Iwanami N,Richter AS,Sikora K,Boehm T
12-5961-82 was used in Flow cytometry/Cell sorting to identify a role for Tnpo3 in regulating the splicing of the pre-mRNA encoding the cognate TCRα chain of iNKT cells.
Tue Jun 20 00:00:00 UTC 2023
A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors.
Cell reports
Fernández-Pisonero I,Clavaín L,Robles-Valero J,Lorenzo-Martín LF,Caloto R,Nieto B,García-Macías C,Oeste CL,Sánchez-Martín M,Abad A,Hortal A,Caballero D,González M,Dosil M,Alarcón B,Bustelo XR
12-5961-82 was used in Flow Cytometry to show, using an inducible knockin mouse model, that R-Ras2Q72L triggers rapid development of a wide spectrum of tumors when somatically expressed in adult tissues.
Tue Mar 15 00:00:00 UTC 2022
TNF hampers intestinal tissue repair in colitis by restricting IL-22 bioavailability.
Mucosal immunology
Ninnemann J,Winsauer C,Bondareva M,Kühl AA,Lozza L,Durek P,Lissner D,Siegmund B,Kaufmann SHE,Mashreghi MF,Nedospasov SA,Kruglov AA
12-5961-82 was used in Flow cytometry/Cell sorting to show how anti-TNF therapy induces mucosal healing by increasing IL-22 availability and implicates new therapeutic opportunities for IBD.
Fri Apr 01 00:00:00 UTC 2022
Cancer genes disfavoring T cell immunity identified via integrated systems approach.
Cell reports
Kishton RJ,Patel SJ,Decker AE,Vodnala SK,Cam M,Yamamoto TN,Patel Y,Sukumar M,Yu Z,Ji M,Henning AN,Gurusamy D,Palmer DC,Stefanescu RA,Girvin AT,Lo W,Pasetto A,Malekzadeh P,Deniger DC,Wood KC,Sanjana NE,Restifo NP
12-5961-82 was used in Flow cytometry/Cell sorting to establish that BIRC2 limits antigen presentation and T cell recognition of tumor cells by suppressing IRF1 activity and provide evidence that BIRC2 inhibition in combination with Adoptive T cell therapies is an effective strategy to increase efficacy.
Tue Aug 02 00:00:00 UTC 2022
A nonredundant role for T cell-derived interleukin 22 in antibacterial defense of colonic crypts.
Immunity
Zindl CL,Witte SJ,Laufer VA,Gao M,Yue Z,Janowski KM,Cai B,Frey BF,Silberger DJ,Harbour SN,Singer JR,Turner H,Lund FE,Vallance BA,Rosenberg AF,Schoeb TR,Chen JY,Hatton RD,Weaver CT
12-5961-82 was used in Flow cytometry/Cell sorting to demonstrate spatiotemporal differences in the production and action of IL-22 by ILCs and T cells during infection and reveal an indispensable role for IL-22-producing T cells in the protection of the intestinal crypts.
Tue Mar 08 00:00:00 UTC 2022
Characterization of the spectrum of trivalent VAV1-mutation-driven tumours using a gene-edited mouse model.
Molecular oncology
Robles-Valero J,Fernández-Nevado L,Cuadrado M,Lorenzo-Martín LF,Fernández-Pisonero I,Abad A,Redín E,Montuenga L,Martín-Zanca D,Bigas A,Mallo M,Dosil M,Bustelo XR
12-5961-82 was used in Flow cytometry/Cell sorting to indicate that VAV1 mutations play critical, although highly cell-type-specific, roles in tumourigenesis.
Sat Oct 01 00:00:00 UTC 2022
Niche-specific MHC II and PD-L1 regulate CD4+CD8αα+ intraepithelial lymphocyte differentiation.
The Journal of experimental medicine
Moon S,Park Y,Hyeon S,Kim YM,Kim JH,Kim H,Park S,Lee KJ,Koo BK,Ha SJ,Lee SW
Published figure using TCR beta monoclonal antibody (Product # 12-5961-82) in Flow Cytometry
Mon Apr 05 00:00:00 UTC 2021
Cofilin1-driven actin dynamics controls migration of thymocytes and is essential for positive selection in the thymus.
Journal of cell science
Salz A,Gurniak C,Jönsson F,Witke W
12-5961 was used in Flow cytometry/Cell sorting to describe a novel role of cofilin1 in the physiological context of migration-dependent cell differentiation.
Fri Mar 06 00:00:00 UTC 2020
Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells.
Nature communications
Lucas B,White AJ,Cosway EJ,Parnell SM,James KD,Jones ND,Ohigashi I,Takahama Y,Jenkinson WE,Anderson G
Published figure using TCR beta monoclonal antibody (Product # 12-5961-82) in Flow Cytometry
Mon May 04 00:00:00 UTC 2020
B7-CD28 co-stimulation modulates central tolerance via thymic clonal deletion and Treg generation through distinct mechanisms.
Nature communications
Watanabe M,Lu Y,Breen M,Hodes RJ
Published figure using TCR beta monoclonal antibody (Product # 12-5961-82) in Flow Cytometry
Tue Dec 08 00:00:00 UTC 2020
Bisphosphoglycerate Mutase Deficiency Protects against Cerebral Malaria and Severe Malaria-Induced Anemia.
Cell reports
Xu G,van Bruggen R,Gualtieri CO,Moradin N,Fois A,Vallerand D,De Sa Tavares Russo M,Bassenden A,Lu W,Tam M,Lesage S,Girouard H,Avizonis DZ,Deblois G,Prchal JT,Stevenson M,Berghuis A,Muir T,Rabinowitz J,Vidal SM,Fodil N,Gros P
12-5961 was used in Flow cytometry/Cell sorting to highlight the importance of BPGM as a regulator of hemoglobin/oxyhemoglobin in malaria pathogenesis and suggest a new potential malaria therapeutic target.
Tue Sep 22 00:00:00 UTC 2020
Requirements for the differentiation of innate T-bethigh memory-phenotype CD4+ T lymphocytes under steady state.
Nature communications
Kawabe T,Yi J,Kawajiri A,Hilligan K,Fang D,Ishii N,Yamane H,Zhu J,Jankovic D,Kim KS,Trinchieri G,Sher A
Published figure using TCR beta monoclonal antibody (Product # 12-5961-82) in Flow Cytometry
Mon Jul 06 00:00:00 UTC 2020
Lymphocyte-Specific Function of the DNA Polymerase Epsilon Subunit Pole3 Revealed by Neomorphic Alleles.
Cell reports
Siamishi I,Iwanami N,Clapes T,Trompouki E,O'Meara CP,Boehm T
12-5961 was used in Flow cytometry/Cell sorting to serve as a paradigm to understand the molecular basis of cell-type-specific non-replicative functions of the ubiquitous POLE complex.
Tue Jun 16 00:00:00 UTC 2020
Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence.
Molecular cell
Zhang H,Alsaleh G,Feltham J,Sun Y,Napolitano G,Riffelmacher T,Charles P,Frau L,Hublitz P,Yu Z,Mohammed S,Ballabio A,Balabanov S,Mellor J,Simon AK
12-5961 was used in Flow cytometry/Cell sorting to reveal an unexpected autophagy regulatory mechanism mediated by eIF5A at the translational level, which can be harnessed to reverse immune senescence in humans.
Thu Oct 03 00:00:00 UTC 2019
Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death.
Nature communications
Sasaki K,Himeno A,Nakagawa T,Sasaki Y,Kiyonari H,Iwai K
Published figure using TCR beta monoclonal antibody (Product # 12-5961-82) in Flow Cytometry
Wed Aug 28 00:00:00 UTC 2019
CD160 serves as a negative regulator of NKT cells in acute hepatic injury.
Nature communications
Kim TJ,Park G,Kim J,Lim SA,Kim J,Im K,Shin MH,Fu YX,Del Rio ML,Rodriguez-Barbosa JI,Yee C,Suh KS,Kim SJ,Ha SJ,Lee KM
Published figure using TCR beta monoclonal antibody (Product # 12-5961-82) in Flow Cytometry
Mon Jul 22 00:00:00 UTC 2019
Qa-1-Restricted CD8+ T Cells Can Compensate for the Absence of Conventional T Cells during Viral Infection.
Cell reports
Anderson CK,Reilly EC,Lee AY,Brossay L
12-5961 was used in Flow cytometry/Cell sorting to study compensatory mechanisms in immune responses to viruses when classical T cell immunity has been evaded.
Tue Apr 09 00:00:00 UTC 2019
Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells.
Cell
Gaya M,Barral P,Burbage M,Aggarwal S,Montaner B,Warren Navia A,Aid M,Tsui C,Maldonado P,Nair U,Ghneim K,Fallon PG,Sekaly RP,Barouch DH,Shalek AK,Bruckbauer A,Strid J,Batista FD
Published figure using TCR beta monoclonal antibody (Product # 12-5961-82) in Flow Cytometry
Thu Jan 25 00:00:00 UTC 2018
CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature.
Nature neuroscience
Louveau A,Herz J,Alme MN,Salvador AF,Dong MQ,Viar KE,Herod SG,Knopp J,Setliff JC,Lupi AL,Da Mesquita S,Frost EL,Gaultier A,Harris TH,Cao R,Hu S,Lukens JR,Smirnov I,Overall CC,Oliver G,Kipnis J
12-5961 was used in Flow cytometry/Cell sorting to demonstrate that meningeal lymphatics fulfill two critical criteria: they assist in the drainage of cerebrospinal fluid components and enable immune cells to enter draining lymph nodes in a CCR7-dependent manner.
Mon Oct 01 00:00:00 UTC 2018
STAT1 is a sex-specific tumor suppressor in colitis-associated colorectal cancer.
Molecular oncology
Crnčec I,Modak M,Gordziel C,Svinka J,Scharf I,Moritsch S,Pathria P,Schlederer M,Kenner L,Timelthaler G,Müller M,Strobl B,Casanova E,Bayer E,Mohr T,Stöckl J,Friedrich K,Eferl R
Published figure using TCR beta monoclonal antibody (Product # 12-5961-82) in Flow Cytometry
Sun Apr 01 00:00:00 UTC 2018
Invariant natural killer T-cell development and function with loss of microRNA-155.
Immunology
Frias AB,Buechel HM,Neupane A,D'Cruz LM
12-5961 was used in Flow cytometry/Cell sorting to examine the role of microRNA-155 in the development and function of invariant natural killer T cells.
Thu Feb 01 00:00:00 UTC 2018
Differential requirement of kindlin-3 for T cell progenitor homing to the non-vascularized and vascularized thymus.
eLife
Moretti FA,Klapproth S,Ruppert R,Margraf A,Weber J,Pick R,Scheiermann C,Sperandio M,Fässler R,Moser M
Published figure using TCR beta monoclonal antibody (Product # 12-5961-82) in Flow Cytometry
Thu Sep 06 00:00:00 UTC 2018
Non-redundant Functions of IL-6 Produced by Macrophages and Dendritic Cells in Allergic Airway Inflammation.
Frontiers in immunology
Gubernatorova EO,Gorshkova EA,Namakanova OA,Zvartsev RV,Hidalgo J,Drutskaya MS,Tumanov AV,Nedospasov SA
12-5961 was used in Flow cytometry/Cell sorting to indicate that IL-6 plays a pathogenic role in the HDM-induced asthma model and that lung macrophages and dendritic cells are the predominant sources of pathogenic IL-6 but contribute differently to the disease.
Wed Oct 02 00:00:00 UTC 2019
Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling.
Nature medicine
Giles DA,Moreno-Fernandez ME,Stankiewicz TE,Graspeuntner S,Cappelletti M,Wu D,Mukherjee R,Chan CC,Lawson MJ,Klarquist J,Sünderhauf A,Softic S,Kahn CR,Stemmer K,Iwakura Y,Aronow BJ,Karns R,Steinbrecher KA,Karp CL,Sheridan R,Shanmukhappa SK,Reynaud D,Haslam DB,Sina C,Rupp J,Hogan SP,Divanovic S
12-5961 was used in Flow cytometry/Cell sorting to show thermoneutral housing provides a sex-independent model of exacerbated NAFLD in mice and represents a novel approach for interrogation of the cellular and molecular mechanisms underlying disease pathogenesis.
Sat Jul 01 00:00:00 UTC 2017
Interleukin-33-Activated Islet-Resident Innate Lymphoid Cells Promote Insulin Secretion through Myeloid Cell Retinoic Acid Production.
Immunity
Dalmas E,Lehmann FM,Dror E,Wueest S,Thienel C,Borsigova M,Stawiski M,Traunecker E,Lucchini FC,Dapito DH,Kallert SM,Guigas B,Pattou F,Kerr-Conte J,Maechler P,Girard JP,Konrad D,Wolfrum C,Böni-Schnetzler M,Finke D,Donath MY
12-5961 was used in Flow cytometry/Cell sorting to provide evidence that an immunometabolic crosstalk between islet-derived IL-33, ILC2s, and myeloid cells fosters insulin secretion.
Tue Nov 21 00:00:00 UTC 2017
A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia.
Cancer cell
Robles-Valero J,Lorenzo-Martín LF,Menacho-Márquez M,Fernández-Pisonero I,Abad A,Camós M,Toribio ML,Espinosa L,Bigas A,Bustelo XR
12-5961 was used in Flow cytometry/Cell sorting to report that the GEF Vav1 unexpectedly possesses tumor-suppressor functions in immature T cells.
Mon Nov 13 00:00:00 UTC 2017
Culling of APCs by inflammatory cell death pathways restricts TIM3 and PD-1 expression and promotes the survival of primed CD8 T cells.
Cell death and differentiation
Patel R,Kim K,Shutinoski B,Wachholz K,Krishnan L,Sad S
12-5961 was used in Flow cytometry/Cell sorting to evaluate the impact of premature cell death of antigen-presenting cells by Caspase-1- and RipK3-signalling pathways on CD8+ T-cell priming during infection of mice with Salmonella typhimurium.
Wed Nov 01 00:00:00 UTC 2017
1810011o10 Rik Inhibits the Antitumor Effect of Intratumoral CD8+ T Cells through Suppression of Notch2 Pathway in a Murine Hepatocellular Carcinoma Model.
Frontiers in immunology
Dai K,Huang L,Huang YB,Chen ZB,Yang LH,Jiang YA
Published figure using TCR beta monoclonal antibody (Product # 12-5961-82) in Flow Cytometry
Wed Nov 20 00:00:00 UTC 2019
Lineage-Specific Metabolic Properties and Vulnerabilities of T Cells in the Demyelinating Central Nervous System.
Journal of immunology (Baltimore, Md. : 1950)
Seki SM,Stevenson M,Rosen AM,Arandjelovic S,Gemta L,Bullock TNJ,Gaultier A
12-5961-82 was used in Magnetic cell separation to demonstrate the metabolic properties of T cells in the demyelinating central nervous system in vivo.
Thu Jun 15 00:00:00 UTC 2017
Targeted genome editing restores T cell differentiation in a humanized X-SCID pluripotent stem cell disease model.
Scientific reports
Alzubi J,Pallant C,Mussolino C,Howe SJ,Thrasher AJ,Cathomen T
Published figure using TCR beta monoclonal antibody (Product # 12-5961-82) in Flow Cytometry
Fri Sep 29 00:00:00 UTC 2017
Hypoxia-Inducible Factor-2α Limits Natural Killer T Cell Cytotoxicity in Renal Ischemia/Reperfusion Injury.
Journal of the American Society of Nephrology : JASN
Zhang J,Han C,Dai H,Hou J,Dong Y,Cui X,Xu L,Zhang M,Xia Q
Published figure using TCR beta monoclonal antibody (Product # 12-5961-82) in Flow Cytometry
Fri Jan 01 00:00:00 UTC 2016
CD8+ T cells drive autoimmune hematopoietic stem cell dysfunction and bone marrow failure.
Journal of autoimmunity
Gravano DM,Al-Kuhlani M,Davini D,Sanders PD,Manilay JO,Hoyer KK
12-5961 was used in Flow cytometry/Cell sorting to investigate whether CD8+ T cells play a non-redundant role in driving bone marrow failure.
Thu Dec 01 00:00:00 UTC 2016
Environmental and Genetic Activation of Hypothalamic BDNF Modulates T-cell Immunity to Exert an Anticancer Phenotype.
Cancer immunology research
Xiao R,Bergin SM,Huang W,Slater AM,Liu X,Judd RT,Lin ED,Widstrom KJ,Scoville SD,Yu J,Caligiuri MA,Cao L
Published figure using TCR beta monoclonal antibody (Product # 12-5961-82) in Flow Cytometry
Wed Jun 01 00:00:00 UTC 2016
Id2 regulates hyporesponsive invariant natural killer T cells.
Immunology and cell biology
Stradner MH,Cheung KP,Lasorella A,Goldrath AW,D'Cruz LM
12-5961 was used in Flow cytometry/Cell sorting to propose that downregulation of Id2 expression is essential to induction of the anti-inflammatory state in iNKT cells.
Mon Aug 01 00:00:00 UTC 2016
Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1.
Nature communications
Ishikawa E,Kosako H,Yasuda T,Ohmuraya M,Araki K,Kurosaki T,Saito T,Yamasaki S
Published figure using TCR beta monoclonal antibody (Product # 12-5961-82) in Flow Cytometry
Tue Sep 27 00:00:00 UTC 2016
Regulation of Inflammation by IL-17A and IL-17F Modulates Non-Alcoholic Fatty Liver Disease Pathogenesis.
PloS one
Giles DA,Moreno-Fernandez ME,Stankiewicz TE,Cappelletti M,Huppert SS,Iwakura Y,Dong C,Shanmukhappa SK,Divanovic S
12-5961 was used in Flow cytometry/Cell sorting to indicate that the IL-17 axis also plays a role in a MCDD-induced model of NAFLD pathogenesis.
Tue Jul 19 00:00:00 UTC 2016
MHC-mismatched mixed chimerism augments thymic regulatory T-cell production and prevents relapse of EAE in mice.
Proceedings of the National Academy of Sciences of the United States of America
Wu L,Li N,Zhang M,Xue SL,Cassady K,Lin Q,Riggs AD,Zeng D
Published figure using TCR beta monoclonal antibody (Product # 12-5961-82) in Flow Cytometry
Tue Dec 29 00:00:00 UTC 2015
NK-, NKT- and CD8-Derived IFNγ Drives Myeloid Cell Activation and Erythrophagocytosis, Resulting in Trypanosomosis-Associated Acute Anemia.
PLoS pathogens
Cnops J,De Trez C,Stijlemans B,Keirsse J,Kauffmann F,Barkhuizen M,Keeton R,Boon L,Brombacher F,Magez S
12-5961 was used in Flow cytometry/Cell sorting to show that NK, NKT and CD8+ T cell-derived IFNγ is a critical mediator in trypanosomosis-associated pathology.
Mon Jun 01 00:00:00 UTC 2015
Antibiotics in neonatal life increase murine susceptibility to experimental psoriasis.
Nature communications
Zanvit P,Konkel JE,Jiao X,Kasagi S,Zhang D,Wu R,Chia C,Ajami NJ,Smith DP,Petrosino JF,Abbatiello B,Nakatsukasa H,Chen Q,Belkaid Y,Chen ZJ,Chen W
Published figure using TCR beta monoclonal antibody (Product # 12-5961-82) in Flow Cytometry
Tue Sep 29 00:00:00 UTC 2015
Immunoglobulin E plays an immunoregulatory role in lupus.
The Journal of experimental medicine
Dema B,Charles N,Pellefigues C,Ricks TK,Suzuki R,Jiang C,Scheffel J,Hasni S,Hoffman V,Jablonski M,Sacré K,Gobert D,Papo T,Daugas E,Crampton S,Bolland S,Rivera J
12-5961 was used in Flow cytometry/Cell sorting to explore the effect of IgE deficiency on the inflammatory response in FcγRIIB-deficient mice, which hastens and results in a more aggressive lupuslike disease.
Mon Oct 20 00:00:00 UTC 2014
CCR10 regulates balanced maintenance and function of resident regulatory and effector T cells to promote immune homeostasis in the skin.
The Journal of allergy and clinical immunology
Xia M,Hu S,Fu Y,Jin W,Yi Q,Matsui Y,Yang J,McDowell MA,Sarkar S,Kalia V,Xiong N
12-5961 was used in Flow cytometry/Cell sorting to investigate the functional importance of CCR10/CCL27 in vivo, showing that CCR10 regulates maintenance and function of regulatory and effector T cells to promote immune homeostasis.
Mon Sep 01 00:00:00 UTC 2014
E and Id proteins influence invariant NKT cell sublineage differentiation and proliferation.
Journal of immunology (Baltimore, Md. : 1950)
D'Cruz LM,Stradner MH,Yang CY,Goldrath AW
12-5961 was used in Flow cytometry/Cell sorting to investigate the mechanism by which E and Id proteins control the development of invariant NKT sublineages after positive selection.
Sat Mar 01 00:00:00 UTC 2014
Autophagy is a critical regulator of memory CD8(+) T cell formation.
eLife
Puleston DJ,Zhang H,Powell TJ,Lipina E,Sims S,Panse I,Watson AS,Cerundolo V,Townsend AR,Klenerman P,Simon AK
12-5961 was used in Flow cytometry/Cell sorting to show that mice lacking the autophagy gene Atg7 in T cells failed to establish CD8(+) T cell memory to influenza and MCMV infection.
Tue Nov 11 00:00:00 UTC 2014
SIRT2 deficiency modulates macrophage polarization and susceptibility to experimental colitis.
PloS one
Lo Sasso G,Menzies KJ,Mottis A,Piersigilli A,Perino A,Yamamoto H,Schoonjans K,Auwerx J
12-5961 was used in Flow cytometry/Cell sorting to investigate SIRT2 protection against development of inflammatory processes.
Tue Nov 24 00:00:00 UTC 2015
Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4⁺ T cell immunity.
Nature immunology
Reis BS,Rogoz A,Costa-Pinto FA,Taniuchi I,Mucida D
Published figure using TCR beta monoclonal antibody (Product # 12-5961-82) in Flow Cytometry
Fri Mar 01 00:00:00 UTC 2013
Identification of beryllium-dependent peptides recognized by CD4+ T cells in chronic beryllium disease.
The Journal of experimental medicine
Falta MT,Pinilla C,Mack DG,Tinega AN,Crawford F,Giulianotti M,Santos R,Clayton GM,Wang Y,Zhang X,Maier LA,Marrack P,Kappler JW,Fontenot AP
12-5961-82 was used in Immunocytochemistry to identify mimotopes and endogenous self-peptides that bind to MHCII and beryllium, forming the pathogenic complex recognised by CD4 T cells in chronic beryllium disease.
Mon Jul 01 00:00:00 UTC 2013
Delayed anti-CD3 therapy results in depletion of alloreactive T cells and the dominance of Foxp3+ CD4+ graft infiltrating cells.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Goto R,You S,Zaitsu M,Chatenoud L,Wood KJ
12-5961 was used in Flow cytometry/Cell sorting to investigate the result of delayed anti-CD3 therapy on the number and dominance of alloreactive/graft infiltrating cells.
Mon Jul 01 00:00:00 UTC 2013
IL-33 signaling regulates innate and adaptive immunity to Cryptococcus neoformans.
Journal of immunology (Baltimore, Md. : 1950)
Flaczyk A,Duerr CU,Shourian M,Lafferty EI,Fritz JH,Qureshi ST
12-5961 was used in Flow cytometry/Cell sorting to study how allergic patterns of lung inflammation are mediated as a host response to Cryptococcus neoformans infection.
Sun Sep 01 00:00:00 UTC 2013
Cancer regression and neurological toxicity following anti-MAGE-A3 TCR gene therapy.
Journal of immunotherapy (Hagerstown, Md. : 1997)
Morgan RA,Chinnasamy N,Abate-Daga D,Gros A,Robbins PF,Zheng Z,Dudley ME,Feldman SA,Yang JC,Sherry RM,Phan GQ,Hughes MS,Kammula US,Miller AD,Hessman CJ,Stewart AA,Restifo NP,Quezado MM,Alimchandani M,Rosenberg AZ,Nath A,Wang T,Bielekova B,Wuest SC,Akula N,McMahon FJ,Wilde S,Mosetter B,Schendel DJ,Laurencot CM,Rosenberg SA
12-5961 was used in Flow cytometry/Cell sorting to investigate how a previously unrecognized expression of MAGE-A12 in human brain initiates a TCR-mediated inflammatory response that results in neuronal cell destruction.
Fri Feb 01 00:00:00 UTC 2013
Mucosal and systemic T cell response in mice intragastrically infected with Neospora caninum tachyzoites.
Veterinary research
Correia A,Ferreirinha P,Costa AA,Dias J,Melo J,Costa R,Ribeiro A,Faustino A,Teixeira L,Rocha A,Vilanova M
12-5961 was used in Flow cytometry/Cell sorting to indicate that TCRαβ+ CD8+ cells contribute to host protection by producing IFN-γ during gastrointestinal infection with Neospora caninum tachyzoites.
Sat Aug 10 00:00:00 UTC 2013
CD30 is required for activation of a unique subset of interleukin-17A-producing γδ T cells in innate immunity against Mycobacterium bovis Bacillus Calmette-Guerin infection.
Infection and immunity
Guo Y,Sun X,Shibata K,Yamada H,Muta H,Podack ER,Yoshikai Y
12-5961 was used in Flow cytometry/Cell sorting to demonstrate the involvement of CD30 signalling in the production of IL-17A by γδ T cells following BCG infection.
Tue Oct 01 00:00:00 UTC 2013
A method for high purity sorting of rare cell subsets applied to TDC.
Journal of immunological methods
Kuka M,Ashwell JD
12-5961 was used in Flow cytometry/Cell sorting to describe a customised gating strategy and a sorting protocol for the isolation of T(DC).
Tue Dec 31 00:00:00 UTC 2013
Ymer acts as a multifunctional regulator in nuclear factor-κB and Fas signaling pathways.
Molecular medicine (Cambridge, Mass.)
Tsukiyama T,Matsuda-Tsukiyama M,Bohgaki M,Terai S,Tanaka S,Hatakeyama S
12-5961 was used in Flow cytometry/Cell sorting to explore the role of Ymer as a positive or negative regulator in several signalling pathways in mice.
Wed May 09 00:00:00 UTC 2012
Neonatal rhinovirus infection induces mucous metaplasia and airways hyperresponsiveness.
Journal of immunology (Baltimore, Md. : 1950)
Schneider D,Hong JY,Popova AP,Bowman ER,Linn MJ,McLean AM,Zhao Y,Sonstein J,Bentley JK,Weinberg JB,Lukacs NW,Curtis JL,Sajjan US,Hershenson MB
12-5961 was used in Flow cytometry/Cell sorting to conclude that neonatal RV1B infection leads to persistent airway inflammation, in part mediated by IL-13.
Thu Mar 15 00:00:00 UTC 2012
Direct reduction of antigen receptor expression in polyclonal B cell populations developing in vivo results in light chain receptor editing.
Journal of immunology (Baltimore, Md. : 1950)
Shen S,Manser T
12-5961 was used in Immunofluorescence on frozen tissues to test the role of BCR expression plays in receptor editing in an polyclonal, in vivo population of B cells.
Sun Jan 01 00:00:00 UTC 2012
Differential requirements for IRF-2 in generation of CD1d-independent T cells bearing NK cell receptors.
Journal of immunology (Baltimore, Md. : 1950)
Notake T,Horisawa S,Sanjo H,Miyagawa S,Hida S,Taki S
12-5961 was used in Flow cytometry/Cell sorting to investigate the mechanisms behind the generation and function of NKR(+) T cells.
Tue May 15 00:00:00 UTC 2012
Epidermal ablation of Dlx3 is linked to IL-17-associated skin inflammation.
Proceedings of the National Academy of Sciences of the United States of America
Hwang J,Kita R,Kwon HS,Choi EH,Lee SH,Udey MC,Morasso MI
12-5961 was used in Flow cytometry/Cell sorting to investigate the role of Distal-less 3 (Dlx3) in cutaneous biology and pathophysiology, showing that ablation is linked to IL-17-associated skin inflammation.
Tue Jul 12 00:00:00 UTC 2011
Restricted microbiota and absence of cognate TCR antigen leads to an unbalanced generation of Th17 cells.
Journal of immunology (Baltimore, Md. : 1950)
Lochner M,Bérard M,Sawa S,Hauer S,Gaboriau-Routhiau V,Fernandez TD,Snel J,Bousso P,Cerf-Bensussan N,Eberl G
12-5961 was used in Flow cytometry/Cell sorting to demonstrate that a complex microbiota and cognate antigen are required to generate a properly regulated set of Foxp3+RORγt+ T cells and Th17 cells.
Tue Feb 01 00:00:00 UTC 2011
Clonal analysis reveals uniformity in the molecular profile and lineage potential of CCR9(+) and CCR9(-) thymus-settling progenitors.
Journal of immunology (Baltimore, Md. : 1950)
Desanti GE,Jenkinson WE,Parnell SM,Boudil A,Gautreau-Rolland L,Eksteen B,Ezine S,Lane PJ,Jenkinson EJ,Anderson G
12-5961 was used in Flow cytometry/Cell sorting to suggest that the earliest T cell progenitors represent a developmentally homogeneous progenitor pool that ensures the efficient generation of the first cohorts of T cells during thymus development.
Sun May 01 00:00:00 UTC 2011
CD169(+) macrophages present lipid antigens to mediate early activation of iNKT cells in lymph nodes.
Nature immunology
Barral P,Polzella P,Bruckbauer A,van Rooijen N,Besra GS,Cerundolo V,Batista FD
12-5961 was used in Flow cytometry/Cell sorting to investigate how and where invariant natural killer T cells encounter antigens in vivo.
Thu Apr 01 00:00:00 UTC 2010
Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia.
Nature immunology
Hodson DJ,Janas ML,Galloway A,Bell SE,Andrews S,Li CM,Pannell R,Siebel CW,MacDonald HR,De Keersmaecker K,Ferrando AA,Grutz G,Turner M
12-5961 was used in Flow cytometry/Cell sorting to establish a role for ZFP36L1 and ZFP36L2 during thymocyte development and in the prevention of malignant transformation.
Sun Aug 01 00:00:00 UTC 2010
Replication allows inactivation of a knocked-in locus control region in inappropriate cell lineages.
Proceedings of the National Academy of Sciences of the United States of America
Menzel U,Ktistaki E,Tolaini M,Veiga-Fernandes H,Kioussis D
12-5961 was used in Flow cytometry/Cell sorting to explore the effect of a locus control region on a developmentally regulated locus in the mouse CD8 gene complex.
Tue Sep 28 00:00:00 UTC 2010
Experimental cerebral malaria progresses independently of the Nlrp3 inflammasome.
European journal of immunology
Reimer T,Shaw MH,Franchi L,Coban C,Ishii KJ,Akira S,Horii T,Rodriguez A,Núñez G
12-5961 was used in Flow cytometry/Cell sorting to study the role of Nlrp3 in experimental cerebral malaria.
Mon Mar 01 00:00:00 UTC 2010
Thymic alterations in GM2 gangliosidoses model mice.
PloS one
Kanzaki S,Yamaguchi A,Yamaguchi K,Kojima Y,Suzuki K,Koumitsu N,Nagashima Y,Nagahama K,Ehara M,Hirayasu Y,Ryo A,Aoki I,Yamanaka S
12-5961 was used in Flow cytometry/Cell sorting to study the Hexb(-/-) mouse model of Sandhoff disease, showing alterations to the thymus, potentially due to FcRγ.
Tue Aug 10 00:00:00 UTC 2010
Endogenous IL-21 restricts CD8+ T cell expansion and is not required for tumor immunity.
Journal of immunology (Baltimore, Md. : 1950)
Søndergaard H,Coquet JM,Uldrich AP,McLaughlin N,Godfrey DI,Sivakumar PV,Skak K,Smyth MJ
12-5961 was used in Flow cytometry/Cell sorting to reveal novel immunosuppressive actions of interleukin-21.
Tue Dec 01 00:00:00 UTC 2009
In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cells.
The Journal of experimental medicine
Lochner M,Peduto L,Cherrier M,Sawa S,Langa F,Varona R,Riethmacher D,Si-Tahar M,Di Santo JP,Eberl G
12-5961 was used in Flow cytometry/Cell sorting to study how potentially antagonistic pro-inflammatory IL-17-producing and regulatory Foxp3(+) RORgamma t(+) T cells coexist and are tightly controlled.
Mon Jun 09 00:00:00 UTC 2008
Non-redundant function of the MEK5-ERK5 pathway in thymocyte apoptosis.
The EMBO journal
Sohn SJ,Lewis GM,Winoto A
12-5961 was used in Flow cytometry/Cell sorting to define the contribution of the MEK5-ERK5 pathway in T-cell development.
Wed Jul 09 00:00:00 UTC 2008
Ly49 cluster sequence analysis in a mouse model of diabetes: an expanded repertoire of activating receptors in the NOD genome.
Genes and immunity
Belanger S,Tai LH,Anderson SK,Makrigiannis AP
12-5961 was used in Flow cytometry/Cell sorting to assess the contribution of the natural killer cell receptor Ly49 to the acceleration of disease in non-obese diabetic mice.
Mon Sep 01 00:00:00 UTC 2008
Hierarchy of Notch-Delta interactions promoting T cell lineage commitment and maturation.
The Journal of experimental medicine
Besseyrias V,Fiorini E,Strobl LJ,Zimber-Strobl U,Dumortier A,Koch U,Arcangeli ML,Ezine S,Macdonald HR,Radtke F
12-5961 was used in Flow cytometry/Cell sorting to study the Notch-Delta interactions that promote T cell development.
Mon Feb 19 00:00:00 UTC 2007
Presenilins regulate alphabeta T cell development by modulating TCR signaling.
The Journal of experimental medicine
Laky K,Fowlkes BJ
12-5961 was used in Flow cytometry/Cell sorting to suggest a model in which PS-dependent Notch signalling influences positive selection and the development of alphabeta T cells by modifying TCR signal transduction.
Mon Sep 03 00:00:00 UTC 2007
Immature hematopoietic cells display selective requirements for adhesion- and degranulation-promoting adaptor protein in development and homeostatsis.
European journal of immunology
Dluzniewska J,Zou L,Harmon IR,Ellingson MT,Peterson EJ
12-5961-82 was used in Flow Cytometry to highlight the dynamic regulation of ADAP during T cell maturation and document expression patterns that suggest a possible role for ADAP in development of non-T hematopoietic lineages.
Thu Nov 01 00:00:00 UTC 2007
