Product References
Tnpo3 controls splicing of the pre-mRNA encoding the canonical TCR α chain of iNKT cells.
Nature communications
Iwanami N,Richter AS,Sikora K,Boehm T
45-5961-82 was used in Flow cytometry/Cell sorting to identify a role for Tnpo3 in regulating the splicing of the pre-mRNA encoding the cognate TCRα chain of iNKT cells.
Tue Jun 20 00:00:00 UTC 2023
Abdominopelvic FLASH Irradiation Improves PD-1 Immune Checkpoint Inhibition in Preclinical Models of Ovarian Cancer.
Molecular cancer therapeutics
Eggold JT,Chow S,Melemenidis S,Wang J,Natarajan S,Loo PE,Manjappa R,Viswanathan V,Kidd EA,Engleman E,Dorigo O,Loo BW,Rankin EB
45-5961-82 was used in Flow cytometry/Cell sorting to highlight the potential for FLASH irradiation to improve the therapeutic efficacy of checkpoint inhibition in the treatment of ovarian cancer.
Tue Feb 01 00:00:00 UTC 2022
A prebiotic diet modulates microglial states and motor deficits in α-synuclein overexpressing mice.
eLife
Abdel-Haq R,Schlachetzki JCM,Boktor JC,Cantu-Jungles TM,Thron T,Zhang M,Bostick JW,Khazaei T,Chilakala S,Morais LH,Humphrey G,Keshavarzian A,Katz JE,Thomson M,Knight R,Gradinaru V,Hamaker BR,Glass CK,Mazmanian SK
45-5961-82 was used in Flow Cytometry to investigate whether a fiber-rich diet influences microglial function in α-synuclein overexpressing (ASO) mice, a preclinical model with PD-like symptoms and pathology.
Tue Nov 08 00:00:00 UTC 2022
Pannexin 1 channels facilitate communication between T cells to restrict the severity of airway inflammation.
Immunity
Medina CB,Chiu YH,Stremska ME,Lucas CD,Poon I,Tung KS,Elliott MR,Desai B,Lorenz UM,Bayliss DA,Ravichandran KS
45-5961-82 was used in Flow cytometry/Cell sorting to uncover an immunoregulatory role for the nucleotide release channel, Panx1, in T cell crosstalk during airway disease.
Tue Aug 10 00:00:00 UTC 2021
Dysbiosis exacerbates colitis by promoting ubiquitination and accumulation of the innate immune adaptor STING in myeloid cells.
Immunity
Shmuel-Galia L,Humphries F,Lei X,Ceglia S,Wilson R,Jiang Z,Ketelut-Carneiro N,Foley SE,Pechhold S,Houghton J,Muneeruddin K,Shaffer SA,McCormick BA,Reboldi A,Ward D,Marshak-Rothstein A,Fitzgerald KA
45-5961-82 was used in Flow cytometry/Cell sorting to suggest a positive feedback loop wherein dysbiosis foments the accumulation of STING in intestinal myeloid cells, driving intestinal inflammation.
Tue Jun 08 00:00:00 UTC 2021
Murine model of colonization with fungal pathogen Candida auris to explore skin tropism, host risk factors and therapeutic strategies.
Cell host & microbe
Huang X,Hurabielle C,Drummond RA,Bouladoux N,Desai JV,Sim CK,Belkaid Y,Lionakis MS,Segre JA
45-5961-82 was used in Flow Cytometry to develop a murine skin topical exposure model for C. auris to dissect risk factors for colonization and to test interventions that might protect patients.
Wed Feb 10 00:00:00 UTC 2021
Niche-specific MHC II and PD-L1 regulate CD4+CD8αα+ intraepithelial lymphocyte differentiation.
The Journal of experimental medicine
Moon S,Park Y,Hyeon S,Kim YM,Kim JH,Kim H,Park S,Lee KJ,Koo BK,Ha SJ,Lee SW
Published figure using TCR beta monoclonal antibody (Product # 45-5961-82) in Flow Cytometry
Mon Apr 05 00:00:00 UTC 2021
T cell self-reactivity during thymic development dictates the timing of positive selection.
eLife
Lutes LK,Steier Z,McIntyre LL,Pandey S,Kaminski J,Hoover AR,Ariotti S,Streets A,Yosef N,Robey EA
45-5961-82 was used in Flow Cytometry to imply that thymocytes with low self-reactivity downregulate TCR sensitivity more slowly during positive selection, and associate membrane ion channel expression with thymocyte self-reactivity and progress through positive selection.
Thu Apr 22 00:00:00 UTC 2021
Sex-specific adipose tissue imprinting of regulatory T cells.
Nature
Vasanthakumar A,Chisanga D,Blume J,Gloury R,Britt K,Henstridge DC,Zhan Y,Torres SV,Liene S,Collins N,Cao E,Sidwell T,Li C,Spallanzani RG,Liao Y,Beavis PA,Gebhardt T,Trevaskis N,Nutt SL,Zajac JD,Davey RA,Febbraio MA,Mathis D,Shi W,Kallies A
45-5961-82 was used in Flow Cytometry to find that sex-specific differences in Treg cells from visceral adipose tissue are determined by the tissue niche in a sex-hormone-dependent manner to limit adipose tissue inflammation.
Sun Mar 01 00:00:00 UTC 2020
Serum Amyloid A Proteins Induce Pathogenic Th17 Cells and Promote Inflammatory Disease.
Cell
Lee JY,Hall JA,Kroehling L,Wu L,Najar T,Nguyen HH,Lin WY,Yeung ST,Silva HM,Li D,Hine A,Loke P,Hudesman D,Martin JC,Kenigsberg E,Merad M,Khanna KM,Littman DR
45-5961 was used in Flow cytometry/Cell sorting to suggest that serum amyloid A proteins direct a pathogenic pro-inflammatory Th17 cell differentiation program and promote Th17-mediated inflammatory diseases.
Thu Jan 09 00:00:00 UTC 2020
Extreme disruption of heterochromatin is required for accelerated hematopoietic aging.
Blood
Keenan CR,Iannarella N,Naselli G,Bediaga NG,Johanson TM,Harrison LC,Allan RS
45-5961-82 was used in Flow Cytometry to indicate that the hematopoietic system has a remarkable tolerance for major disruptions in chromatin structure and reveal a role for Suv39h2 in depositing sufficient H3K9me3 to protect the entire hematopoietic system from changes associated with premature aging.
Thu Jun 04 00:00:00 UTC 2020
Induced Tumor Heterogeneity Reveals Factors Informing Radiation and Immunotherapy Combinations.
Clinical cancer research : an official journal of the American Association for Cancer Research
Aguilera TA,Elghonaimy EA,Shehade H,Rafat M,Castellini L,Jiang D,Kariolis M,Koong AC,Le QT,Ellies LG,Rankin EB,Graves EE,Giaccia AJ
45-5961 was used in Flow cytometry/Cell sorting to investigate how induced tumor heterogeneity influences immune responses to radiotherapy with different proportions of mixed immune-responsive and unresponsive tumor cells in a triple-negative breast cancer model.
Mon Jun 15 00:00:00 UTC 2020
Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells.
Nature communications
Lucas B,White AJ,Cosway EJ,Parnell SM,James KD,Jones ND,Ohigashi I,Takahama Y,Jenkinson WE,Anderson G
Published figure using TCR beta monoclonal antibody (Product # 45-5961-82) in Flow Cytometry
Mon May 04 00:00:00 UTC 2020
Requirements for the differentiation of innate T-bethigh memory-phenotype CD4+ T lymphocytes under steady state.
Nature communications
Kawabe T,Yi J,Kawajiri A,Hilligan K,Fang D,Ishii N,Yamane H,Zhu J,Jankovic D,Kim KS,Trinchieri G,Sher A
45-5961 was used in Flow cytometry/Cell sorting to study whether MP CD4+ T cells are functionally heterogeneous and, if so, what signals specify the differentiation of MP cell subpopulations under homeostatic conditions.
Mon Jul 06 00:00:00 UTC 2020
Requirements for the differentiation of innate T-bethigh memory-phenotype CD4+ T lymphocytes under steady state.
Nature communications
Kawabe T,Yi J,Kawajiri A,Hilligan K,Fang D,Ishii N,Yamane H,Zhu J,Jankovic D,Kim KS,Trinchieri G,Sher A
45-5961 was used in Flow cytometry/Cell sorting to study whether MP CD4+ T cells are functionally heterogeneous and, if so, what signals specify the differentiation of MP cell subpopulations under homeostatic conditions.
Mon Jul 06 00:00:00 UTC 2020
B7-CD28 co-stimulation modulates central tolerance via thymic clonal deletion and Treg generation through distinct mechanisms.
Nature communications
Watanabe M,Lu Y,Breen M,Hodes RJ
Published figure using TCR beta monoclonal antibody (Product # 45-5961-82) in Flow Cytometry
Tue Dec 08 00:00:00 UTC 2020
Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis.
Nature communications
Sidwell T,Liao Y,Garnham AL,Vasanthakumar A,Gloury R,Blume J,Teh PP,Chisanga D,Thelemann C,de Labastida Rivera F,Engwerda CR,Corcoran L,Kometani K,Kurosaki T,Smyth GK,Shi W,Kallies A
45-5961 was used in Flow cytometry/Cell sorting to show homeostasis of thymically-derived and peripherally-derived Treg cells is maintained through the balancing of TCR signaling induced transcriptional activity by Bach2.
Tue Jan 14 00:00:00 UTC 2020
Intestinal vitamin D receptor knockout protects from oxazolone-induced colitis.
Cell death & disease
Shi Y,Liu Z,Cui X,Zhao Q,Liu T
45-5961 was used in Flow cytometry/Cell sorting to identify that intestinal vitamin D receptor knockout protected against oxazolone-induced colitis in mice by blocking Th2 cell response and reducing the function of intestinal invariant natural killer T cells.
Mon Jun 15 00:00:00 UTC 2020
Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity.
Frontiers in immunology
Myers DR,Abram CL,Wildes D,Belwafa A,Welsh AMN,Schulze CJ,Choy TJ,Nguyen T,Omaque N,Hu Y,Singh M,Hansen R,Goldsmith MA,Quintana E,Smith JAM,Lowell CA
45-5961 was used in Flow cytometry/Cell sorting to suggest that targeting Shp1 may be an attractive therapeutic strategy for boosting the immune response to cancer via a mechanism involving both innate and adaptive leukocytes.
Mon Jun 14 00:00:00 UTC 2021
Characterization of the pathoimmunology of necrotizing enterocolitis reveals novel therapeutic opportunities.
Nature communications
Cho SX,Rudloff I,Lao JC,Pang MA,Goldberg R,Bui CB,McLean CA,Stock M,Klassert TE,Slevogt H,Mangan NE,Cheng W,Fischer D,Gfroerer S,Sandhu MK,Ngo D,Bujotzek A,Lariviere L,Schumacher F,Tiefenthaler G,Beker F,Collins C,Kamlin COF,König K,Malhotra A,Tan K,Theda C,Veldman A,Ellisdon AM,Whisstock JC,Berger PJ,Nold-Petry CA,Nold MF
45-5961 was used in Flow cytometry/Cell sorting to implicate type 3 cytokines, TLRs and IL-37 as potential targets for novel Necrotizing enterocolitis therapies.
Fri Nov 13 00:00:00 UTC 2020
The Bone Marrow Protects and Optimizes Immunological Memory during Dietary Restriction.
Cell
Collins N,Han SJ,Enamorado M,Link VM,Huang B,Moseman EA,Kishton RJ,Shannon JP,Dixit D,Schwab SR,Hickman HD,Restifo NP,McGavern DB,Schwartzberg PL,Belkaid Y
45-5961-82 was used in Flow Cytometry to show that memory T cells collapsed in secondary lymphoid organs in the context of dietary restriction (DR) but dramatically accumulated within the bone marrow (BM), where they adopted a state associated with energy conservation.
Thu Aug 22 00:00:00 UTC 2019
Characterization of Transcriptional Regulatory Networks that Promote and Restrict Identities and Functions of Intestinal Innate Lymphoid Cells.
Immunity
Pokrovskii M,Hall JA,Ochayon DE,Yi R,Chaimowitz NS,Seelamneni H,Carriero N,Watters A,Waggoner SN,Littman DR,Bonneau R,Miraldi ER
45-5961 was used in Flow cytometry/Cell sorting to study regulatory interactions between transcription factors and genes within intestinal type 1, 2, and 3 innate lymphoid cells subsets.
Tue Jul 16 00:00:00 UTC 2019
CD160 serves as a negative regulator of NKT cells in acute hepatic injury.
Nature communications
Kim TJ,Park G,Kim J,Lim SA,Kim J,Im K,Shin MH,Fu YX,Del Rio ML,Rodriguez-Barbosa JI,Yee C,Suh KS,Kim SJ,Ha SJ,Lee KM
Published figure using TCR beta monoclonal antibody (Product # 45-5961-82) in Flow Cytometry
Mon Jul 22 00:00:00 UTC 2019
Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells.
Cell
Gaya M,Barral P,Burbage M,Aggarwal S,Montaner B,Warren Navia A,Aid M,Tsui C,Maldonado P,Nair U,Ghneim K,Fallon PG,Sekaly RP,Barouch DH,Shalek AK,Bruckbauer A,Strid J,Batista FD
Published figure using TCR beta monoclonal antibody (Product # 45-5961-82) in Flow Cytometry
Thu Jan 25 00:00:00 UTC 2018
STAT1 is a sex-specific tumor suppressor in colitis-associated colorectal cancer.
Molecular oncology
Crnčec I,Modak M,Gordziel C,Svinka J,Scharf I,Moritsch S,Pathria P,Schlederer M,Kenner L,Timelthaler G,Müller M,Strobl B,Casanova E,Bayer E,Mohr T,Stöckl J,Friedrich K,Eferl R
Published figure using TCR beta monoclonal antibody (Product # 45-5961-82) in Flow Cytometry
Sun Apr 01 00:00:00 UTC 2018
Differential requirement of kindlin-3 for T cell progenitor homing to the non-vascularized and vascularized thymus.
eLife
Moretti FA,Klapproth S,Ruppert R,Margraf A,Weber J,Pick R,Scheiermann C,Sperandio M,Fässler R,Moser M
Published figure using TCR beta monoclonal antibody (Product # 45-5961-82) in Flow Cytometry
Thu Sep 06 00:00:00 UTC 2018
A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia.
Cancer cell
Robles-Valero J,Lorenzo-Martín LF,Menacho-Márquez M,Fernández-Pisonero I,Abad A,Camós M,Toribio ML,Espinosa L,Bigas A,Bustelo XR
Published figure using TCR beta monoclonal antibody (Product # 45-5961-82) in Flow Cytometry
Mon Nov 13 00:00:00 UTC 2017
Periodontitis induced by Porphyromonas gingivalis drives periodontal microbiota dysbiosis and insulin resistance via an impaired adaptive immune response.
Gut
Blasco-Baque V,Garidou L,Pomié C,Escoula Q,Loubieres P,Le Gall-David S,Lemaitre M,Nicolas S,Klopp P,Waget A,Azalbert V,Colom A,Bonnaure-Mallet M,Kemoun P,Serino M,Burcelin R
45-5961 was used in Flow cytometry/Cell sorting to determine the causal mechanism responsible for the enhancement of hyperglycemia and insulin resistance in mice fed a fat-enriched diet.
Mon May 01 00:00:00 UTC 2017
Commensal Microbes and Hair Follicle Morphogenesis Coordinately Drive Treg Migration into Neonatal Skin.
Cell host & microbe
Scharschmidt TC,Vasquez KS,Pauli ML,Leitner EG,Chu K,Truong HA,Lowe MM,Sanchez Rodriguez R,Ali N,Laszik ZG,Sonnenburg JL,Millar SE,Rosenblum MD
45-5961 was used in Flow cytometry/Cell sorting to show that hair follicle (HF) development facilitates the accumulation of regulatory T cells in neonatal skin and that upon skin entry these cells localise to HFs.
Wed Apr 12 00:00:00 UTC 2017
1810011o10 Rik Inhibits the Antitumor Effect of Intratumoral CD8+ T Cells through Suppression of Notch2 Pathway in a Murine Hepatocellular Carcinoma Model.
Frontiers in immunology
Dai K,Huang L,Huang YB,Chen ZB,Yang LH,Jiang YA
Published figure using TCR beta monoclonal antibody (Product # 45-5961-82) in Flow Cytometry
Wed Nov 20 00:00:00 UTC 2019
Guidelines for the use of flow cytometry and cell sorting in immunological studies.
European journal of immunology
Cossarizza A,Chang HD,Radbruch A,Akdis M,Andrä I,Annunziato F,Bacher P,Barnaba V,Battistini L,Bauer WM,Baumgart S,Becher B,Beisker W,Berek C,Blanco A,Borsellino G,Boulais PE,Brinkman RR,Büscher M,Busch DH,Bushnell TP,Cao X,Cavani A,Chattopadhyay PK,Cheng Q,Chow S,Clerici M,Cooke A,Cosma A,Cosmi L,Cumano A,Dang VD,Davies D,De Biasi S,Del Zotto G,Della Bella S,Dellabona P,Deniz G,Dessing M,Diefenbach A,Di Santo J,Dieli F,Dolf A,Donnenberg VS,Dörner T,Ehrhardt GRA,Endl E,Engel P,Engelhardt B,Esser C,Everts B,Dreher A,Falk CS,Fehniger TA,Filby A,Fillatreau S,Follo M,Förster I,Foster J,Foulds GA,Frenette PS,Galbraith D,Garbi N,García-Godoy MD,Geginat J,Ghoreschi K,Gibellini L,Goettlinger C,Goodyear CS,Gori A,Grogan J,Gross M,Grützkau A,Grummitt D,Hahn J,Hammer Q,Hauser AE,Haviland DL,Hedley D,Herrera G,Herrmann M,Hiepe F,Holland T,Hombrink P,Houston JP,Hoyer BF,Huang B,Hunter CA,Iannone A,Jäck HM,Jávega B,Jonjic S,Juelke K,Jung S,Kaiser T,Kalina T,Keller B,Khan S,Kienhöfer D,Kroneis T,Kunkel D,Kurts C,Kvistborg P,Lannigan J,Lantz O,Larbi A,LeibundGut-Landmann S,Leipold MD,Levings MK,Litwin V,Liu Y,Lohoff M,Lombardi G,Lopez L,Lovett-Racke A,Lubberts E,Ludewig B,Lugli E,Maecker HT,Martrus G,Matarese G,Maueröder C,McGrath M,McInnes I,Mei HE,Melchers F,Melzer S,Mielenz D,Mills K,Mirrer D,Mjösberg J,Moore J,Moran B,Moretta A,Moretta L,Mosmann TR,Müller S,Müller W,Münz C,Multhoff G,Munoz LE,Murphy KM,Nakayama T,Nasi M,Neudörfl C,Nolan J,Nourshargh S,O'Connor JE,Ouyang W,Oxenius A,Palankar R,Panse I,Peterson P,Peth C,Petriz J,Philips D,Pickl W,Piconese S,Pinti M,Pockley AG,Podolska MJ,Pucillo C,Quataert SA,Radstake TRDJ,Rajwa B,Rebhahn JA,Recktenwald D,Remmerswaal EBM,Rezvani K,Rico LG,Robinson JP,Romagnani C,Rubartelli A,Ruckert B,Ruland J,Sakaguchi S,Sala-de-Oyanguren F,Samstag Y,Sanderson S,Sawitzki B,Scheffold A,Schiemann M,Schildberg F,Schimisky E,Schmid SA,Schmitt S,Schober K,Schüler T,Schulz AR,Schumacher T,Scotta C,Shankey TV,Shemer A,Simon AK,Spidlen J,Stall AM,Stark R,Stehle C,Stein M,Steinmetz T,Stockinger H,Takahama Y,Tarnok A,Tian Z,Toldi G,Tornack J,Traggiai E,Trotter J,Ulrich H,van der Braber M,van Lier RAW,Veldhoen M,Vento-Asturias S,Vieira P,Voehringer D,Volk HD,von Volkmann K,Waisman A,Walker R,Ward MD,Warnatz K,Warth S,Watson JV,Watzl C,Wegener L,Wiedemann A,Wienands J,Willimsky G,Wing J,Wurst P,Yu L,Yue A,Zhang Q,Zhao Y,Ziegler S,Zimmermann J
45-5961 was used in Flow cytometry/Cell sorting to collect the currently accepted best methods for monitoring most of the variation of the major players of immune system.
Sun Oct 01 00:00:00 UTC 2017
Targeted genome editing restores T cell differentiation in a humanized X-SCID pluripotent stem cell disease model.
Scientific reports
Alzubi J,Pallant C,Mussolino C,Howe SJ,Thrasher AJ,Cathomen T
Published figure using TCR beta monoclonal antibody (Product # 45-5961-82) in Flow Cytometry
Fri Sep 29 00:00:00 UTC 2017
An ultrastructural investigation of tumors undergoing regression mediated by immunotherapy.
Oncotarget
Westwood JA,Ellis S,Danne J,Johnson C,Oorschot V,Ramm G,Tscharke DC,Davenport AJ,Whisstock JC,Darcy PK,Kershaw MH,Slaney CY
45-5961 was used in Flow cytometry/Cell sorting to investigate morphologic and cellular features of tumors responding to immunotherapy, composed of adoptive transfer of dual-specific CAR T cells and a vaccine, supported by preconditioning irradiation and interleukin-2.
Fri Dec 29 00:00:00 UTC 2017
Calcium-mediated shaping of naive CD4 T-cell phenotype and function.
eLife
Guichard V,Bonilla N,Durand A,Audemard-Verger A,Guilbert T,Martin B,Lucas B,Auffray C
45-5961-82 was used in Flow Cytometry to demonstrate that calcium-mediated activation of the calcineurin pathway acts as a rheostat to shape the phenotype and effector potential of naive CD4 T cells in the steady-state.
Thu Dec 14 00:00:00 UTC 2017
Hypoxia-Inducible Factor-2α Limits Natural Killer T Cell Cytotoxicity in Renal Ischemia/Reperfusion Injury.
Journal of the American Society of Nephrology : JASN
Zhang J,Han C,Dai H,Hou J,Dong Y,Cui X,Xu L,Zhang M,Xia Q
Published figure using TCR beta monoclonal antibody (Product # 45-5961-82) in Flow Cytometry
Fri Jan 01 00:00:00 UTC 2016
Lack of autophagy induces steroid-resistant airway inflammation.
The Journal of allergy and clinical immunology
Suzuki Y,Maazi H,Sankaranarayanan I,Lam J,Khoo B,Soroosh P,Barbers RG,James Ou JH,Jung JU,Akbari O
45-5961 was used in Flow cytometry/Cell sorting to examine the role of autophagy in lung inflammation and the pathogenesis of corticosteroid-resistant neutrophilic asthma.
Sun May 01 00:00:00 UTC 2016
Environmental and Genetic Activation of Hypothalamic BDNF Modulates T-cell Immunity to Exert an Anticancer Phenotype.
Cancer immunology research
Xiao R,Bergin SM,Huang W,Slater AM,Liu X,Judd RT,Lin ED,Widstrom KJ,Scoville SD,Yu J,Caligiuri MA,Cao L
Published figure using TCR beta monoclonal antibody (Product # 45-5961-82) in Flow Cytometry
Wed Jun 01 00:00:00 UTC 2016
Triggering the adaptive immune system with commensal gut bacteria protects against insulin resistance and dysglycemia.
Molecular metabolism
Pomié C,Blasco-Baque V,Klopp P,Nicolas S,Waget A,Loubières P,Azalbert V,Puel A,Lopez F,Dray C,Valet P,Lelouvier B,Servant F,Courtney M,Amar J,Burcelin R,Garidou L
45-5961 was used in Flow cytometry/Cell sorting to investigate how glycemia and insulin sensitivity can be regulated by triggering the adaptive immunity to microbiota interaction.
Wed Jun 01 00:00:00 UTC 2016
Depletion of regulatory T cells leads to an exacerbation of delayed-type hypersensitivity arthritis in C57BL/6 mice that can be counteracted by IL-17 blockade.
Disease models & mechanisms
Atkinson SM,Hoffmann U,Hamann A,Bach E,Danneskiold-Samsøe NB,Kristiansen K,Serikawa K,Fox B,Kruse K,Haase C,Skov S,Nansen A
45-5961 was used in Flow cytometry/Cell sorting to investigate the role of regulatory T cells in delayed-type hypersensitivity arthritis through depletion, and the rescuing effect of IL-7 in connection to regulatory T cell depletion.
Fri Apr 01 00:00:00 UTC 2016
Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1.
Nature communications
Ishikawa E,Kosako H,Yasuda T,Ohmuraya M,Araki K,Kurosaki T,Saito T,Yamasaki S
Published figure using TCR beta monoclonal antibody (Product # 45-5961-82) in Flow Cytometry
Tue Sep 27 00:00:00 UTC 2016
Reprogramming the immunological microenvironment through radiation and targeting Axl.
Nature communications
Aguilera TA,Rafat M,Castellini L,Shehade H,Kariolis MS,Hui AB,Stehr H,von Eyben R,Jiang D,Ellies LG,Koong AC,Diehn M,Rankin EB,Graves EE,Giaccia AJ
45-5961 was used in Flow cytometry/Cell sorting to investigate a novel role for Axl in suppressing antigen presentation through MHCI, and enhancing cytokine release, which promotes a suppressive myeloid microenvironment.
Fri Dec 23 00:00:00 UTC 2016
A role for multiple chimeric antigen receptor-expressing leukocytes in antigen-specific responses to cancer.
Oncotarget
Yong CS,John LB,Devaud C,Prince MH,Johnstone RW,Trapani JA,Darcy PK,Kershaw MH
45-5961 was used in Flow cytometry/Cell sorting to characterise the function of leukocytes from transgenic mice expressing a chimeric antigen receptor under the control of vav, and determine the ability of these mice to respond to ERB-expressing tumours.
Tue Jun 07 00:00:00 UTC 2016
MHC-mismatched mixed chimerism augments thymic regulatory T-cell production and prevents relapse of EAE in mice.
Proceedings of the National Academy of Sciences of the United States of America
Wu L,Li N,Zhang M,Xue SL,Cassady K,Lin Q,Riggs AD,Zeng D
Published figure using TCR beta monoclonal antibody (Product # 45-5961-82) in Flow Cytometry
Tue Dec 29 00:00:00 UTC 2015
The Inflammatory Caspases-1 and -11 Mediate the Pathogenesis of Dermatitis in Sharpin-Deficient Mice.
Journal of immunology (Baltimore, Md. : 1950)
Douglas T,Champagne C,Morizot A,Lapointe JM,Saleh M
45-5961 was used in Flow cytometry/Cell sorting to implicate the inflammasome as an important initiating signal in skin disease pathogenesis.
Tue Sep 01 00:00:00 UTC 2015
Induction of Th17 cells by segmented filamentous bacteria in the murine intestine.
Journal of immunological methods
Farkas AM,Panea C,Goto Y,Nakato G,Galan-Diez M,Narushima S,Honda K,Ivanov II
45-5961 was used in Flow cytometry/Cell sorting to study the ability of segmented filamentous bacteria (SFB) to modulate the host immune system through induction of IgA and Th17 cells, and examine the kinetics of SFB colonisation and Th17 cell induction.
Mon Jun 01 00:00:00 UTC 2015
Antibiotics in neonatal life increase murine susceptibility to experimental psoriasis.
Nature communications
Zanvit P,Konkel JE,Jiao X,Kasagi S,Zhang D,Wu R,Chia C,Ajami NJ,Smith DP,Petrosino JF,Abbatiello B,Nakatsukasa H,Chen Q,Belkaid Y,Chen ZJ,Chen W
45-5961 was used in Flow cytometry/Cell sorting to investigate the link between neonatal antibiotic-mediated imbalance in microbiota and development of experimental psoriasis.
Tue Sep 29 00:00:00 UTC 2015
Expression of a Chimeric Antigen Receptor in Multiple Leukocyte Lineages in Transgenic Mice.
PloS one
Yong CS,Westwood JA,Schröder J,Papenfuss AT,von Scheidt B,Moeller M,Devaud C,Darcy PK,Kershaw MH
45-5961 was used in Flow cytometry/Cell sorting to generate a mouse model expressing chimeric antigen receptors (CARs) specific for a tumour antigen under a pan-hematopoietic promoter.
Wed Jun 08 00:00:00 UTC 2016
CD4+ T cells promote the transition from hypertrophy to heart failure during chronic pressure overload.
Circulation
Laroumanie F,Douin-Echinard V,Pozzo J,Lairez O,Tortosa F,Vinel C,Delage C,Calise D,Dutaur M,Parini A,Pizzinat N
45-5961 was used in Flow cytometry/Cell sorting to investigate the involvement of T cells in the progression to heart failure using a transverse aortic constriction (TAC) model.
Tue May 27 00:00:00 UTC 2014
Tissues in different anatomical sites can sculpt and vary the tumor microenvironment to affect responses to therapy.
Molecular therapy : the journal of the American Society of Gene Therapy
Devaud C,Westwood JA,John LB,Flynn JK,Paquet-Fifield S,Duong CP,Yong CS,Pegram HJ,Stacker SA,Achen MG,Stewart TJ,Snyder LA,Teng MW,Smyth MJ,Darcy PK,Kershaw MH
45-5961 was used in Flow cytometry/Cell sorting to explore the relationship between tumour microenvironments and efficacy of immunotherapy.
Wed Jan 01 00:00:00 UTC 2014
Foxp3 expression in macrophages associated with RENCA tumors in mice.
PloS one
Devaud C,Yong CS,John LB,Westwood JA,Duong CP,House CM,Denoyer D,Li J,Darcy PK,Kershaw MH
45-5961 was used in Flow cytometry/Cell sorting to study how tumour-associated macrophages could express Foxp3.
Mon Nov 16 00:00:00 UTC 2015
Differential potency of regulatory T cell-mediated immunosuppression in kidney tumors compared to subcutaneous tumors.
Oncoimmunology
Devaud C,Westwood JA,Teng MW,John LB,Yong CS,Duong CP,Smyth MJ,Darcy PK,Kershaw MH
45-5961 was used in Flow cytometry/Cell sorting to provide insights into the immunosuppressive nature of the immune response generated in the kidney microenvironment.
Sat Nov 01 00:00:00 UTC 2014
Dendritic cell subset distributions in the aorta in healthy and atherosclerotic mice.
PloS one
Busch M,Westhofen TC,Koch M,Lutz MB,Zernecke A
45-5961 was used in Flow cytometry/Cell sorting to perform a systematic analysis of dendritic cells and their accumulation characteristics during atherogenesis.
Tue Oct 21 00:00:00 UTC 2014
Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4⁺ T cell immunity.
Nature immunology
Reis BS,Rogoz A,Costa-Pinto FA,Taniuchi I,Mucida D
Published figure using TCR beta monoclonal antibody (Product # 45-5961-82) in Flow Cytometry
Fri Mar 01 00:00:00 UTC 2013
CD4(+) T Cell-Receptor Repertoire Diversity is Compromised in the Spleen but Not in the Bone Marrow of Aged Mice Due to Private and Sporadic Clonal Expansions.
Frontiers in immunology
Shifrut E,Baruch K,Gal H,Ndifon W,Deczkowska A,Schwartz M,Friedman N
45-5961 was used in Flow cytometry/Cell sorting to investigate the relationship between immune cell diversity and age in various tissues.
Fri Dec 06 00:00:00 UTC 2013
Recipient myeloid-derived immunomodulatory cells induce PD-1 ligand-dependent donor CD4+Foxp3+ regulatory T cell proliferation and donor-recipient immune tolerance after murine nonmyeloablative bone marrow transplantation.
Journal of immunology (Baltimore, Md. : 1950)
van der Merwe M,Abdelsamed HA,Seth A,Ong T,Vogel P,Pillai AB
45-5961 was used in Flow cytometry/Cell sorting to investigate the specific mechanisms of immune tolerance following TLI/ATS conditioning, showing the induction of PD-1 ligand-dependent donor Treg proliferation and donor-recipient immune tolerance.
Sun Dec 01 00:00:00 UTC 2013
Staphylococcus aureus alpha toxin suppresses effective innate and adaptive immune responses in a murine dermonecrosis model.
PloS one
Tkaczyk C,Hamilton MM,Datta V,Yang XP,Hilliard JJ,Stephens GL,Sadowska A,Hua L,O'Day T,Suzich J,Stover CK,Sellman BR
45-5961 was used in Flow cytometry/Cell sorting to investigate the effect of alpha toxin on the immune response against soft tissue infections, showing that alpha toxin suppresses effective innate and adaptive immune responses.
Mon Jun 23 00:00:00 UTC 2014
Highly self-reactive naive CD4 T cells are prone to differentiate into regulatory T cells.
Nature communications
Martin B,Auffray C,Delpoux A,Pommier A,Durand A,Charvet C,Yakonowsky P,de Boysson H,Bonilla N,Audemard A,Sparwasser T,Salomon BL,Malissen B,Lucas B
45-5961 was used in Flow cytometry/Cell sorting to show that naive CD4 T cells with the highest avidity for self are prone to differentiate into regulatory T cells.
Thu Feb 27 00:00:00 UTC 2014
Type I interferons maintain Foxp3 expression and T-regulatory cell functions under inflammatory conditions in mice.
Gastroenterology
Lee SE,Li X,Kim JC,Lee J,González-Navajas JM,Hong SH,Park IK,Rhee JH,Raz E
45-5961 was used in Flow cytometry/Cell sorting to study the role of type I interferons during intestinal homeostasis regulation in a T cell-induced colitis mouse model.
Sun Jul 01 00:00:00 UTC 2012
ZBTB1 is a determinant of lymphoid development.
The Journal of experimental medicine
Siggs OM,Li X,Xia Y,Beutler B
45-5961 was used in Flow cytometry/Cell sorting to identify a mutation causative of complete and cell-intrinsic T cell deficiency.
Mon Jan 16 00:00:00 UTC 2012
Establishment and characterization of a sustained delayed-type hypersensitivity model with arthritic manifestations in C57BL/6J mice.
Arthritis research & therapy
Atkinson SM,Usher PA,Kvist PH,Markholst H,Haase C,Nansen A
45-5961 was used in Flow cytometry/Cell sorting to demonstrate that the DTH-arthritis model could hold potential in the preclinical screening of novel drugs targeting RA.
Thu Jun 07 00:00:00 UTC 2012
RelA and RelB transcription factors in distinct thymocyte populations control lymphotoxin-dependent interleukin-17 production in γδ T cells.
Immunity
Powolny-Budnicka I,Riemann M,Tänzer S,Schmid RM,Hehlgans T,Weih F
45-5961 was used in Flow cytometry/Cell sorting to investigate the contribution of NF-κB to IL-17 production by T cells, showing that RelA and RelB in distinct thymocyte populations control lymphotoxin-dependent IL-17 production.
Fri Mar 25 00:00:00 UTC 2011
Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus.
Nature immunology
Monticelli LA,Sonnenberg GF,Abt MC,Alenghat T,Ziegler CG,Doering TA,Angelosanto JM,Laidlaw BJ,Yang CY,Sathaliyawala T,Kubota M,Turner D,Diamond JM,Goldrath AW,Farber DL,Collman RG,Wherry EJ,Artis D
45-5961 was used in Flow cytometry/Cell sorting to demonstrate a critical role for lung ILCs in restoring airway epithelial integrity and tissue homeostasis after viral replication.
Tue Nov 01 00:00:00 UTC 2011
PreTCR and TCRγδ signal initiation in thymocyte progenitors does not require domains implicated in receptor oligomerization.
Science signaling
Mahtani-Patching J,Neves JF,Pang DJ,Stoenchev KV,Aguirre-Blanco AM,Silva-Santos B,Pennington DJ
45-5961 was used in Flow cytometry/Cell sorting to demonstrate that signal initiation by preTCR and TCRγδ during thymocyte development does not require regions of the extracellular domains that were implicated in receptor oligomerisation.
Tue Jul 19 00:00:00 UTC 2011
Negative selection by IgM superantigen defines a B cell central tolerance compartment and reveals mutations allowing escape.
Journal of immunology (Baltimore, Md. : 1950)
Duong BH,Ota T,Aoki-Ota M,Cooper AB,Ait-Azzouzene D,Vela JL,Gavin AL,Nemazee D
45-5961 was used in Flow cytometry/Cell sorting to demonstrate the usefulness of reconstituted IgM(b) superantigen hosts in revealing pathways involved in central tolerance.
Thu Dec 01 00:00:00 UTC 2011
A role for granzyme M in TLR4-driven inflammation and endotoxicosis.
Journal of immunology (Baltimore, Md. : 1950)
Anthony DA,Andrews DM,Chow M,Watt SV,House C,Akira S,Bird PI,Trapani JA,Smyth MJ
45-5961 was used in Flow cytometry/Cell sorting to demonstrate that granzymes should be considered as potential key regulators of inflammation.
Sun Aug 01 00:00:00 UTC 2010
Endogenous IL-21 restricts CD8+ T cell expansion and is not required for tumor immunity.
Journal of immunology (Baltimore, Md. : 1950)
Søndergaard H,Coquet JM,Uldrich AP,McLaughlin N,Godfrey DI,Sivakumar PV,Skak K,Smyth MJ
45-5961 was used in Flow cytometry/Cell sorting to reveal novel immunosuppressive actions of interleukin-21.
Tue Dec 01 00:00:00 UTC 2009
