Product References
Immunopeptidomics-based design of mRNA vaccine formulations against Listeria monocytogenes.
Nature communications
Mayer RL,Verbeke R,Asselman C,Aernout I,Gul A,Eggermont D,Boucher K,Thery F,Maia TM,Demol H,Gabriels R,Martens L,Bécavin C,De Smedt SC,Vandekerckhove B,Lentacker I,Impens F
17-5961-82 was used in Flow Cytometry to present results which can serve as a starting point for the development of a clinical mRNA vaccine against Listeria and aid to improve attenuated Listeria vaccines and vectors, demonstrating the power of immunopeptidomics for next-generation bacterial vaccine development.
Fri Oct 14 00:00:00 UTC 2022
A nonredundant role for T cell-derived interleukin 22 in antibacterial defense of colonic crypts.
Immunity
Zindl CL,Witte SJ,Laufer VA,Gao M,Yue Z,Janowski KM,Cai B,Frey BF,Silberger DJ,Harbour SN,Singer JR,Turner H,Lund FE,Vallance BA,Rosenberg AF,Schoeb TR,Chen JY,Hatton RD,Weaver CT
17-5961-82 was used in Flow cytometry/Cell sorting to demonstrate spatiotemporal differences in the production and action of IL-22 by ILCs and T cells during infection and reveal an indispensable role for IL-22-producing T cells in the protection of the intestinal crypts.
Tue Mar 08 00:00:00 UTC 2022
Meningeal lymphatic drainage promotes T cell responses against Toxoplasma gondii but is dispensable for parasite control in the brain.
eLife
Kovacs MA,Cowan MN,Babcock IW,Sibley LA,Still K,Batista SJ,Labuzan SA,Sethi I,Harris TH
17-5961-82 was used in Flow cytometry/Cell sorting to reveal that CNS lymphatic drainage supports the development of peripheral T cell responses against T. gondii but remains dispensable for immune protection of the brain.
Wed Dec 21 00:00:00 UTC 2022
Niche-specific MHC II and PD-L1 regulate CD4+CD8αα+ intraepithelial lymphocyte differentiation.
The Journal of experimental medicine
Moon S,Park Y,Hyeon S,Kim YM,Kim JH,Kim H,Park S,Lee KJ,Koo BK,Ha SJ,Lee SW
Published figure using TCR beta monoclonal antibody (Product # 17-5961-82) in Flow Cytometry
Mon Apr 05 00:00:00 UTC 2021
Cofilin1-driven actin dynamics controls migration of thymocytes and is essential for positive selection in the thymus.
Journal of cell science
Salz A,Gurniak C,Jönsson F,Witke W
17-5961 was used in Flow cytometry/Cell sorting to describe a novel role of cofilin1 in the physiological context of migration-dependent cell differentiation.
Fri Mar 06 00:00:00 UTC 2020
Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells.
Nature communications
Lucas B,White AJ,Cosway EJ,Parnell SM,James KD,Jones ND,Ohigashi I,Takahama Y,Jenkinson WE,Anderson G
Published figure using TCR beta monoclonal antibody (Product # 17-5961-82) in Flow Cytometry
Mon May 04 00:00:00 UTC 2020
B7-CD28 co-stimulation modulates central tolerance via thymic clonal deletion and Treg generation through distinct mechanisms.
Nature communications
Watanabe M,Lu Y,Breen M,Hodes RJ
17-5961 was used in Flow cytometry/Cell sorting to reveal a function of B7-CD28 co-stimulation in shaping the T cell repertoire and limiting autoimmunity through both thymic clonal deletion and Treg cell generation.
Tue Dec 08 00:00:00 UTC 2020
B7-CD28 co-stimulation modulates central tolerance via thymic clonal deletion and Treg generation through distinct mechanisms.
Nature communications
Watanabe M,Lu Y,Breen M,Hodes RJ
17-5961 was used in Flow cytometry/Cell sorting to reveal a function of B7-CD28 co-stimulation in shaping the T cell repertoire and limiting autoimmunity through both thymic clonal deletion and Treg cell generation.
Tue Dec 08 00:00:00 UTC 2020
Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine.
Nature communications
Campesato LF,Budhu S,Tchaicha J,Weng CH,Gigoux M,Cohen IJ,Redmond D,Mangarin L,Pourpe S,Liu C,Zappasodi R,Zamarin D,Cavanaugh J,Castro AC,Manfredi MG,McGovern K,Merghoub T,Wolchok JD
17-5961 was used in Flow cytometry/Cell sorting to show that the AHR pathway is selectively active in IDO/TDO-overexpressing tumors and is associated with resistance to immune checkpoint inhibitors.
Tue Aug 11 00:00:00 UTC 2020
Requirements for the differentiation of innate T-bethigh memory-phenotype CD4+ T lymphocytes under steady state.
Nature communications
Kawabe T,Yi J,Kawajiri A,Hilligan K,Fang D,Ishii N,Yamane H,Zhu J,Jankovic D,Kim KS,Trinchieri G,Sher A
Published figure using TCR beta monoclonal antibody (Product # 17-5961-82) in Flow Cytometry
Mon Jul 06 00:00:00 UTC 2020
The cis-Regulatory Atlas of the Mouse Immune System.
Cell
Yoshida H,Lareau CA,Ramirez RN,Rose SA,Maier B,Wroblewska A,Desland F,Chudnovskiy A,Mortha A,Dominguez C,Tellier J,Kim E,Dwyer D,Shinton S,Nabekura T,Qi Y,Yu B,Robinette M,Kim KW,Wagers A,Rhoads A,Nutt SL,Brown BD,Mostafavi S,Buenrostro JD,Benoist C
17-5961-82 was used in Flow Cytometry to generate matched epigenome and transcriptome measurements in 86 primary cell types that span the mouse immune system and its differentiation cascade.
Thu Feb 07 00:00:00 UTC 2019
Cell-Type-Specific Responses to Interleukin-1 Control Microbial Invasion and Tumor-Elicited Inflammation in Colorectal Cancer.
Immunity
Dmitrieva-Posocco O,Dzutsev A,Posocco DF,Hou V,Yuan W,Thovarai V,Mufazalov IA,Gunzer M,Shilovskiy IP,Khaitov MR,Trinchieri G,Waisman A,Grivennikov SI
17-5961-82 was used in Flow Cytometry to examine the impact of IL-1 signaling, a key regulator of the IL-17 pathway, in different cell types within the CRC microenvironment.
Tue Jan 15 00:00:00 UTC 2019
Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence.
Molecular cell
Zhang H,Alsaleh G,Feltham J,Sun Y,Napolitano G,Riffelmacher T,Charles P,Frau L,Hublitz P,Yu Z,Mohammed S,Ballabio A,Balabanov S,Mellor J,Simon AK
17-5961 was used in Flow cytometry/Cell sorting to reveal an unexpected autophagy regulatory mechanism mediated by eIF5A at the translational level, which can be harnessed to reverse immune senescence in humans.
Thu Oct 03 00:00:00 UTC 2019
Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death.
Nature communications
Sasaki K,Himeno A,Nakagawa T,Sasaki Y,Kiyonari H,Iwai K
Published figure using TCR beta monoclonal antibody (Product # 17-5961-82) in Flow Cytometry
Wed Aug 28 00:00:00 UTC 2019
CD160 serves as a negative regulator of NKT cells in acute hepatic injury.
Nature communications
Kim TJ,Park G,Kim J,Lim SA,Kim J,Im K,Shin MH,Fu YX,Del Rio ML,Rodriguez-Barbosa JI,Yee C,Suh KS,Kim SJ,Ha SJ,Lee KM
Published figure using TCR beta monoclonal antibody (Product # 17-5961-82) in Flow Cytometry
Mon Jul 22 00:00:00 UTC 2019
Keap1-Nrf2 System Plays an Important Role in Invariant Natural Killer T Cell Development and Homeostasis.
Cell reports
Pyaram K,Kumar A,Kim YH,Noel S,Reddy SP,Rabb H,Chang CH
17-5961 was used in Flow cytometry/Cell sorting to report that T cellspecific deletion of Keap1 results in defective development and reduced numbers of invariant natural killer T (NKT) cells in the thymus and the peripheral organs in a cell-intrinsic manner.
Tue Apr 16 00:00:00 UTC 2019
Aryl hydrocarbon receptor activation modulates γδ intestinal intraepithelial lymphocytes and protects against ischemia/reperfusion injury in the murine small intestine.
Molecular medicine reports
Zhang Z,Pu A,Yu M,Xiao W,Sun L,Cai Y,Yang H
17-5961-82 was used in Flow cytometry/Cell sorting to suggest that the AhR plays an important role in protecting the small intestine from I/R and increasing the γδIEL population by decreasing apoptosis of γδIELs.
Fri Mar 01 00:00:00 UTC 2019
The Liver-Stage Plasmodium Infection Is a Critical Checkpoint for Development of Experimental Cerebral Malaria.
Frontiers in immunology
Sato Y,Ries S,Stenzel W,Fillatreau S,Matuschewski K
17-5961 was used in Flow cytometry/Cell sorting to reveal the essential role of early host interactions in the liver that may dampen the subsequent pro-inflammatory immune responses and influence the occurrence of ECM, highlighting a novel checkpoint in this fatal pathology.
Mon Nov 16 00:00:00 UTC 2020
Restricted Expression of the Thymoproteasome Is Required for Thymic Selection and Peripheral Homeostasis of CD8+ T Cells.
Cell reports
Tomaru U,Konno S,Miyajima S,Kimoto R,Onodera M,Kiuchi S,Murata S,Ishizu A,Kasahara M
17-5961 was used in Flow cytometry/Cell sorting to find that thymoproteasomes are essential for positive selection but that the subsequent change in peptide repertoire in the medulla is also crucial for thymic selection and that β5t-derived peptide must be confined to the thymus to avoid autoimmunity in peripheral tissues.
Tue Jan 15 00:00:00 UTC 2019
Noc4L-Mediated Ribosome Biogenesis Controls Activation of Regulatory and Conventional T Cells.
Cell reports
Zhu X,Zhang W,Guo J,Zhang X,Li L,Wang T,Yan J,Zhang F,Hou B,Gao N,Gao GF,Zhou X
17-5961 was used in Flow cytometry/Cell sorting to identify the control of Treg activation and immune tolerance maintenance is due to Noc4L mediated ribosome biogenesis.
Tue Apr 23 00:00:00 UTC 2019
Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells.
Cell
Gaya M,Barral P,Burbage M,Aggarwal S,Montaner B,Warren Navia A,Aid M,Tsui C,Maldonado P,Nair U,Ghneim K,Fallon PG,Sekaly RP,Barouch DH,Shalek AK,Bruckbauer A,Strid J,Batista FD
Published figure using TCR beta monoclonal antibody (Product # 17-5961-82) in Flow Cytometry
Thu Jan 25 00:00:00 UTC 2018
MRI Is a DNA Damage Response Adaptor during Classical Non-homologous End Joining.
Molecular cell
Hung PJ,Johnson B,Chen BR,Byrum AK,Bredemeyer AL,Yewdell WT,Johnson TE,Lee BJ,Deivasigamani S,Hindi I,Amatya P,Gross ML,Paull TT,Pisapia DJ,Chaudhuri J,Petrini JJH,Mosammaparast N,Amarasinghe GK,Zha S,Tyler JK,Sleckman BP
17-5961 was used in Flow cytometry/Cell sorting to investigate if in G1-phase XRCC4 and the XRCC4-like factor-deficient lymphocytes, the modulator of retrovirus infection is required for cNHEJ-mediated repair of DNA double-strand breaks generated by RAG and the I-PpoI endonuclease.
Thu Jul 19 00:00:00 UTC 2018
MicroRNA-150 controls differentiation of intraepithelial lymphocytes through TGF-β receptor II regulation.
The Journal of allergy and clinical immunology
Seo SH,Jang MS,Kim DJ,Kim SM,Oh SC,Jung CR,Park Y,Ha SJ,Jung H,Park YJ,Yoon SR,Choi I,Kim TD
17-5961-82 was used in Flow Cytometry to investigate the regulation of intraepithelial lymphocyte differentiation and the underlying mechanisms in mice.
Sun Apr 01 00:00:00 UTC 2018
STAT1 is a sex-specific tumor suppressor in colitis-associated colorectal cancer.
Molecular oncology
Crnčec I,Modak M,Gordziel C,Svinka J,Scharf I,Moritsch S,Pathria P,Schlederer M,Kenner L,Timelthaler G,Müller M,Strobl B,Casanova E,Bayer E,Mohr T,Stöckl J,Friedrich K,Eferl R
Published figure using TCR beta monoclonal antibody (Product # 17-5961-82) in Flow Cytometry
Sun Apr 01 00:00:00 UTC 2018
Invariant natural killer T-cell development and function with loss of microRNA-155.
Immunology
Frias AB,Buechel HM,Neupane A,D'Cruz LM
17-5961 was used in Flow cytometry/Cell sorting to examine the role of microRNA-155 in the development and function of invariant natural killer T cells.
Thu Feb 01 00:00:00 UTC 2018
Differential requirement of kindlin-3 for T cell progenitor homing to the non-vascularized and vascularized thymus.
eLife
Moretti FA,Klapproth S,Ruppert R,Margraf A,Weber J,Pick R,Scheiermann C,Sperandio M,Fässler R,Moser M
Published figure using TCR beta monoclonal antibody (Product # 17-5961-82) in Flow Cytometry
Thu Sep 06 00:00:00 UTC 2018
Effective screening of T cells recognizing neoantigens and construction of T-cell receptor-engineered T cells.
Oncotarget
Kato T,Matsuda T,Ikeda Y,Park JH,Leisegang M,Yoshimura S,Hikichi T,Harada M,Zewde M,Sato S,Hasegawa K,Kiyotani K,Nakamura Y
17-5961 was used in Flow cytometry/Cell sorting to establish a 2-week protocol for generating and identifying neoantigen-specific T cell receptors (TCRs) from third-party donors making this strategy applicable for clinical use.
Fri Feb 16 00:00:00 UTC 2018
Live imaging and tracking of genome regions in CRISPR/dCas9 knock-in mice.
Genome biology
Duan J,Lu G,Hong Y,Hu Q,Mai X,Guo J,Si X,Wang F,Zhang Y
17-5961 was used in Flow cytometry/Cell sorting to generate and characterise a mouse strain with dCas9-EGFP ubiquitously expressed in various tissues.
Thu Nov 08 00:00:00 UTC 2018
A protocol for generating induced T cells by reprogramming B cells in vivo.
Cell regeneration (London, England)
Weng Q,Hu F,Zhang M,Dong Y,Lv C,Wang Y,Liu X,Wang J
17-5961-82 was used in Flow cytometry/Cell sorting to describe a protocol for generating functional T cells from Hoxb5-expressing B cells in vivo.
Sat Sep 01 00:00:00 UTC 2018
Analyses of a Mutant Foxp3 Allele Reveal BATF as a Critical Transcription Factor in the Differentiation and Accumulation of Tissue Regulatory T Cells.
Immunity
Hayatsu N,Miyao T,Tachibana M,Murakami R,Kimura A,Kato T,Kawakami E,Endo TA,Setoguchi R,Watarai H,Nishikawa T,Yasuda T,Yoshida H,Hori S
17-5961 was used in Flow cytometry/Cell sorting to identify BATF as a regulator of tissue regulatory T cells and suggest that sequence-specific perturbations of Foxp3-DNA interactions can influence specific facets of Treg physiology and the immunopathologies.
Tue Aug 15 00:00:00 UTC 2017
A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia.
Cancer cell
Robles-Valero J,Lorenzo-Martín LF,Menacho-Márquez M,Fernández-Pisonero I,Abad A,Camós M,Toribio ML,Espinosa L,Bigas A,Bustelo XR
Published figure using TCR beta monoclonal antibody (Product # 17-5961-82) in Flow Cytometry
Mon Nov 13 00:00:00 UTC 2017
Epithelial-Cell-Derived Phospholipase A2 Group 1B Is an Endogenous Anthelmintic.
Cell host & microbe
Entwistle LJ,Pelly VS,Coomes SM,Kannan Y,Perez-Lloret J,Czieso S,Silva Dos Santos M,MacRae JI,Collinson L,Sesay A,Nikolov N,Metidji A,Helmby H,Hui DY,Wilson MS
17-5961 was used in Flow cytometry/Cell sorting to uncover epithelial-cell-derived Pla2g1b as an essential mediator of helminth killing.
Wed Oct 11 00:00:00 UTC 2017
Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.
The Journal of experimental medicine
Miao T,Symonds ALJ,Singh R,Symonds JD,Ogbe A,Omodho B,Zhu B,Li S,Wang P
17-5961 was used in Flow cytometry/Cell sorting to define a fundamental function of Egr2 and Egr3, operating as a checkpoint controlling the transition between clonal expansion and differentiation of effector T cells.
Mon Jun 05 00:00:00 UTC 2017
ILC2s regulate adaptive Th2 cell functions via PD-L1 checkpoint control.
The Journal of experimental medicine
Schwartz C,Khan AR,Floudas A,Saunders SP,Hams E,Rodewald HR,McKenzie ANJ,Fallon PG
17-5961 was used in Flow cytometry/Cell sorting to study how group 2 innate lymphoid cells regulate adaptive Th2 cell functions.
Mon Sep 04 00:00:00 UTC 2017
1810011o10 Rik Inhibits the Antitumor Effect of Intratumoral CD8+ T Cells through Suppression of Notch2 Pathway in a Murine Hepatocellular Carcinoma Model.
Frontiers in immunology
Dai K,Huang L,Huang YB,Chen ZB,Yang LH,Jiang YA
Published figure using TCR beta monoclonal antibody (Product # 17-5961-82) in Flow Cytometry
Wed Nov 20 00:00:00 UTC 2019
CD4+ Th2 cells are directly regulated by IL-10 during allergic airway inflammation.
Mucosal immunology
Coomes SM,Kannan Y,Pelly VS,Entwistle LJ,Guidi R,Perez-Lloret J,Nikolov N,Müller W,Wilson MS
17-5961 was used in Flow cytometry/Cell sorting to identify that pathogenic Th2 cells are an important direct target of IL-10 and an insight into IL-10 mediated regualation of allergic airway inflammation.
Sun Jan 01 00:00:00 UTC 2017
MyD88 signaling in dendritic cells and the intestinal epithelium controls immunity against intestinal infection with C. rodentium.
PLoS pathogens
Friedrich C,Mamareli P,Thiemann S,Kruse F,Wang Z,Holzmann B,Strowig T,Sparwasser T,Lochner M
17-5961 was used in Flow cytometry/Cell sorting to suggest that MyD88 signaling in DC and IEC is both essential and sufficient to induce a full spectrum of host responses upon intestinal infection with C. rodentium.
Mon May 01 00:00:00 UTC 2017
Reactive Oxygen Species Regulate the Inflammatory Function of NKT Cells through Promyelocytic Leukemia Zinc Finger.
Journal of immunology (Baltimore, Md. : 1950)
Kim YH,Kumar A,Chang CH,Pyaram K
17-5961 was used in Flow cytometry/Cell sorting to investigate the role of reactive oxygen species in natural killer T cell function.
Wed Nov 15 00:00:00 UTC 2017
Targeted genome editing restores T cell differentiation in a humanized X-SCID pluripotent stem cell disease model.
Scientific reports
Alzubi J,Pallant C,Mussolino C,Howe SJ,Thrasher AJ,Cathomen T
Published figure using TCR beta monoclonal antibody (Product # 17-5961-82) in Flow Cytometry
Fri Sep 29 00:00:00 UTC 2017
Hypoxia-Inducible Factor-2α Limits Natural Killer T Cell Cytotoxicity in Renal Ischemia/Reperfusion Injury.
Journal of the American Society of Nephrology : JASN
Zhang J,Han C,Dai H,Hou J,Dong Y,Cui X,Xu L,Zhang M,Xia Q
Published figure using TCR beta monoclonal antibody (Product # 17-5961-82) in Flow Cytometry
Fri Jan 01 00:00:00 UTC 2016
Environmental and Genetic Activation of Hypothalamic BDNF Modulates T-cell Immunity to Exert an Anticancer Phenotype.
Cancer immunology research
Xiao R,Bergin SM,Huang W,Slater AM,Liu X,Judd RT,Lin ED,Widstrom KJ,Scoville SD,Yu J,Caligiuri MA,Cao L
Published figure using TCR beta monoclonal antibody (Product # 17-5961-82) in Flow Cytometry
Wed Jun 01 00:00:00 UTC 2016
IL-4-producing ILC2s are required for the differentiation of TH2 cells following Heligmosomoides polygyrus infection.
Mucosal immunology
Pelly VS,Kannan Y,Coomes SM,Entwistle LJ,Rückerl D,Seddon B,MacDonald AS,McKenzie A,Wilson MS
17-5961 was used in Flow cytometry/Cell sorting to highlight a previously unrecognised and important role for ILC2-derived IL-4 for TH2 differentiation in a natural TH2-dependent model of human helminthiasis.
Tue Nov 01 00:00:00 UTC 2016
Id2 regulates hyporesponsive invariant natural killer T cells.
Immunology and cell biology
Stradner MH,Cheung KP,Lasorella A,Goldrath AW,D'Cruz LM
17-5961 was used in Flow cytometry/Cell sorting to propose that downregulation of Id2 expression is essential to induction of the anti-inflammatory state in iNKT cells.
Mon Aug 01 00:00:00 UTC 2016
Type I IFN Does Not Promote Susceptibility to Foodborne Listeria monocytogenes.
Journal of immunology (Baltimore, Md. : 1950)
Pitts MG,Myers-Morales T,D'Orazio SE
17-5961 was used in an ELISA assay to investigate whether type I IFN promotes susceptibility to foodborne Listeria monocytogenes.
Fri Apr 01 00:00:00 UTC 2016
Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1.
Nature communications
Ishikawa E,Kosako H,Yasuda T,Ohmuraya M,Araki K,Kurosaki T,Saito T,Yamasaki S
Published figure using TCR beta monoclonal antibody (Product # 17-5961-82) in Flow Cytometry
Tue Sep 27 00:00:00 UTC 2016
Alkylator-Induced and Patient-Derived Xenograft Mouse Models of Therapy-Related Myeloid Neoplasms Model Clinical Disease and Suggest the Presence of Multiple Cell Subpopulations with Leukemia Stem Cell Activity.
PloS one
Jonas BA,Johnson C,Gratzinger D,Majeti R
17-5961 was used in Flow cytometry/Cell sorting to report several new t-AML/MDS mouse models that could potentially be used to further define disease pathogenesis and test novel therapeutics.
Wed Jul 26 00:00:00 UTC 2017
MHC-mismatched mixed chimerism augments thymic regulatory T-cell production and prevents relapse of EAE in mice.
Proceedings of the National Academy of Sciences of the United States of America
Wu L,Li N,Zhang M,Xue SL,Cassady K,Lin Q,Riggs AD,Zeng D
Published figure using TCR beta monoclonal antibody (Product # 17-5961-82) in Flow Cytometry
Tue Dec 29 00:00:00 UTC 2015
IFNγ and IL-12 Restrict Th2 Responses during Helminth/Plasmodium Co-Infection and Promote IFNγ from Th2 Cells.
PLoS pathogens
Coomes SM,Pelly VS,Kannan Y,Okoye IS,Czieso S,Entwistle LJ,Perez-Lloret J,Nikolov N,Potocnik AJ,Biró J,Langhorne J,Wilson MS
17-5961 was used in Flow cytometry/Cell sorting to show that co-infection with Plasmodium spp. may contribute to the chronicity of helminth infection by reducing the frequency of anti-helminth Th2 cells.
Wed Jul 01 00:00:00 UTC 2015
NK-, NKT- and CD8-Derived IFNγ Drives Myeloid Cell Activation and Erythrophagocytosis, Resulting in Trypanosomosis-Associated Acute Anemia.
PLoS pathogens
Cnops J,De Trez C,Stijlemans B,Keirsse J,Kauffmann F,Barkhuizen M,Keeton R,Boon L,Brombacher F,Magez S
17-5961 was used in Flow cytometry/Cell sorting to show that NK, NKT and CD8+ T cell-derived IFNγ is a critical mediator in trypanosomosis-associated pathology.
Mon Jun 01 00:00:00 UTC 2015
Phenotypic and Morphological Properties of Germinal Center Dark Zone Cxcl12-Expressing Reticular Cells.
Journal of immunology (Baltimore, Md. : 1950)
Rodda LB,Bannard O,Ludewig B,Nagasawa T,Cyster JG
17-5961-82 was used in Immunohistochemistry (PFA fixed) to characterise the properties of the stromal cells supporting B cells in the germinal centre dark zone.
Sun Nov 15 00:00:00 UTC 2015
MHC-mismatched mixed chimerism mediates thymic deletion of cross-reactive autoreactive T cells and prevents insulitis in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950)
Racine JJ,Zhang M,Wang M,Morales W,Shen C,Zeng D
17-5961 was used in Flow cytometry/Cell sorting to investigate whether mismatched MHC class II in mixed chimeras mediates deletion of cross-reactive autoreactive thymocytes.
Thu Jan 01 00:00:00 UTC 2015
Antibiotics in neonatal life increase murine susceptibility to experimental psoriasis.
Nature communications
Zanvit P,Konkel JE,Jiao X,Kasagi S,Zhang D,Wu R,Chia C,Ajami NJ,Smith DP,Petrosino JF,Abbatiello B,Nakatsukasa H,Chen Q,Belkaid Y,Chen ZJ,Chen W
Published figure using TCR beta monoclonal antibody (Product # 17-5961-82) in Flow Cytometry
Tue Sep 29 00:00:00 UTC 2015
CCDC88B is a novel regulator of maturation and effector functions of T cells during pathological inflammation.
The Journal of experimental medicine
Kennedy JM,Fodil N,Torre S,Bongfen SE,Olivier JF,Leung V,Langlais D,Meunier C,Berghout J,Langat P,Schwartzentruber J,Majewski J,Lathrop M,Vidal SM,Gros P
17-5961 was used in Flow cytometry/Cell sorting to suggest that CCDC88B is the morbid gene underlying the pleiotropic effect of the 11q13 locus on inflammation.
Mon Dec 15 00:00:00 UTC 2014
Microbiota modulate tumoral immune surveillance in lung through a γδT17 immune cell-dependent mechanism.
Cancer research
Cheng M,Qian L,Shen G,Bian G,Xu T,Xu W,Shen G,Hu S
17-5961 was used in Flow cytometry/Cell sorting to investigate the mechanism by which commensal bacteria modulate the efficiency of tumoral immune surveillance in mucosal tissues.
Fri Aug 01 00:00:00 UTC 2014
BMP4 inhibits breast cancer metastasis by blocking myeloid-derived suppressor cell activity.
Cancer research
Cao Y,Slaney CY,Bidwell BN,Parker BS,Johnstone CN,Rautela J,Eckhardt BL,Anderson RL
17-5961 was used in Flow cytometry/Cell sorting to assess the potential for therapies based on the activation of BMP4 signalling for the treatment of breast cancer.
Mon Sep 15 00:00:00 UTC 2014
IL-17-producing NKT cells depend exclusively on IL-7 for homeostasis and survival.
Mucosal immunology
Webster KE,Kim HO,Kyparissoudis K,Corpuz TM,Pinget GV,Uldrich AP,Brink R,Belz GT,Cho JH,Godfrey DI,Sprent J
17-5961 was used in Flow cytometry/Cell sorting to elucidate the factors that maintain the natural killer T cell population in the periphery.
Mon Sep 01 00:00:00 UTC 2014
Enhanced antibody responses to an HIV-1 membrane-proximal external region antigen in mice reconstituted with cultured lymphocytes.
Journal of immunology (Baltimore, Md. : 1950)
Holl TM,Yang G,Kuraoka M,Verkoczy L,Alam SM,Moody MA,Haynes BF,Kelsoe G
17-5961 was used in Flow cytometry/Cell sorting to assess B cell responses to the HIV-1 2F5 epitope in response to immunisation.
Tue Apr 01 00:00:00 UTC 2014
E and Id proteins influence invariant NKT cell sublineage differentiation and proliferation.
Journal of immunology (Baltimore, Md. : 1950)
D'Cruz LM,Stradner MH,Yang CY,Goldrath AW
17-5961 was used in Flow cytometry/Cell sorting to investigate the mechanism by which E and Id proteins control the development of invariant NKT sublineages after positive selection.
Sat Mar 01 00:00:00 UTC 2014
Specific increase in potency via structure-based design of a TCR.
Journal of immunology (Baltimore, Md. : 1950)
Malecek K,Grigoryan A,Zhong S,Gu WJ,Johnson LA,Rosenberg SA,Cardozo T,Krogsgaard M
17-5961 was used in Flow cytometry/Cell sorting to investigate mutations that can enhance binding affinity of a TCR for adoptive immunotherapy, producing an increase in potency.
Mon Sep 01 00:00:00 UTC 2014
mTORC1-dependent metabolic reprogramming is a prerequisite for NK cell effector function.
Journal of immunology (Baltimore, Md. : 1950)
Donnelly RP,Loftus RM,Keating SE,Liou KT,Biron CA,Gardiner CM,Finlay DK
17-5961 was used in Flow cytometry/Cell sorting to investigate whether mTORC1-controlled metabolism underpins normal natural killer cell proinflammatory functions.
Sat Nov 01 00:00:00 UTC 2014
γδ T cells recognize the insulin B:9-23 peptide antigen when it is dimerized through thiol oxidation.
Molecular immunology
Aydintug MK,Zhang L,Wang C,Liang D,Wands JM,Michels AW,Hirsch B,Day BJ,Zhang G,Sun D,Eisenbarth GS,O'Brien RL,Born WK
17-5961 was used in Flow cytometry/Cell sorting to determine why γδ T cells require a secondary amino acid recognition site on the insulin peptide, B:9-23.
Fri Aug 01 00:00:00 UTC 2014
Small intestinal intraepithelial TCRγδ+ T lymphocytes are present in the premature intestine but selectively reduced in surgical necrotizing enterocolitis.
PloS one
Weitkamp JH,Rosen MJ,Zhao Z,Koyama T,Geem D,Denning TL,Rock MT,Moore DJ,Halpern MD,Matta P,Denning PW
17-5961 was used in Flow cytometry/Cell sorting to study the development of γδ intraepithelial lymphocytes in the ileum of human infants and examine their role in pathogenesis of necrotizing enterocolitis.
Tue Oct 06 00:00:00 UTC 2015
Autophagy is a critical regulator of memory CD8(+) T cell formation.
eLife
Puleston DJ,Zhang H,Powell TJ,Lipina E,Sims S,Panse I,Watson AS,Cerundolo V,Townsend AR,Klenerman P,Simon AK
17-5961 was used in Flow cytometry/Cell sorting to show that mice lacking the autophagy gene Atg7 in T cells failed to establish CD8(+) T cell memory to influenza and MCMV infection.
Tue Nov 11 00:00:00 UTC 2014
No major role for insulin-degrading enzyme in antigen presentation by MHC molecules.
PloS one
Culina S,Mauvais FX,Hsu HT,Burgevin A,Guénette S,Moser A,van Endert P
17-5961 was used in Flow cytometry/Cell sorting to investigate the contribution of IDE to proteasome-independent generation of MHC class I ligands.
Fri May 22 00:00:00 UTC 2015
Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4⁺ T cell immunity.
Nature immunology
Reis BS,Rogoz A,Costa-Pinto FA,Taniuchi I,Mucida D
Published figure using TCR beta monoclonal antibody (Product # 17-5961-82) in Flow Cytometry
Fri Mar 01 00:00:00 UTC 2013
CX3CR1-dependent renal macrophage survival promotes Candida control and host survival.
The Journal of clinical investigation
Lionakis MS,Swamydas M,Fischer BG,Plantinga TS,Johnson MD,Jaeger M,Green NM,Masedunskas A,Weigert R,Mikelis C,Wan W,Lee CC,Lim JK,Rivollier A,Yang JC,Laird GM,Wheeler RT,Alexander BD,Perfect JR,Gao JL,Kullberg BJ,Netea MG,Murphy PM
17-5961 was used in Flow cytometry/Cell sorting to elucidate the roles of innate immune cells in the pathogenesis of C. albicans.
Sun Dec 01 00:00:00 UTC 2013
Host immunity contributes to the anti-melanoma activity of BRAF inhibitors.
The Journal of clinical investigation
Knight DA,Ngiow SF,Li M,Parmenter T,Mok S,Cass A,Haynes NM,Kinross K,Yagita H,Koya RC,Graeber TG,Ribas A,McArthur GA,Smyth MJ
17-5961 was used in Flow cytometry/Cell sorting to investigate the contribution of host immunity to the anti-melanoma activity of BRAF inhibitors.
Fri Mar 01 00:00:00 UTC 2013
Irf8-regulated genomic responses drive pathological inflammation during cerebral malaria.
PLoS pathogens
Berghout J,Langlais D,Radovanovic I,Tam M,MacMicking JD,Stevenson MM,Gros P
17-5961 was used in Flow cytometry/Cell sorting to show that inactivation of Irf8 confers protection against the development of cerebral malaria.
Tue Feb 18 00:00:00 UTC 2014
Amelioration of experimental autoimmune encephalomyelitis by the quinoline-3-carboxamide paquinimod: reduced priming of proinflammatory effector CD4(+) T cells.
The American journal of pathology
Helmersson S,Sundstedt A,Deronic A,Leanderson T,Ivars F
17-5961 was used in Flow cytometry/Cell sorting to show that paquinimod treatment during the first 5 days after induction of experimental autoimmune encephalomyelitis eases disease symptoms.
Wed May 01 00:00:00 UTC 2013
Cutting edge: IL-25 elicits innate lymphoid type 2 and type II NKT cells that regulate obesity in mice.
Journal of immunology (Baltimore, Md. : 1950)
Hams E,Locksley RM,McKenzie AN,Fallon PG
17-5961 was used in Flow cytometry/Cell sorting to investigate the role of IL-25-responsive innate cells in regulating weight and glucose homeostasis.
Sun Dec 01 00:00:00 UTC 2013
Thymic damage, impaired negative selection, and development of chronic graft-versus-host disease caused by donor CD4+ and CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950)
Wu T,Young JS,Johnston H,Ni X,Deng R,Racine J,Wang M,Wang A,Todorov I,Wang J,Zeng D
17-5961 was used in Flow cytometry/Cell sorting to evaluate the contribution of T cells to the induction of chronic graft-versus-host disease.
Mon Jul 01 00:00:00 UTC 2013
Lack of PD-L1 expression by iNKT cells improves the course of influenza A infection.
PloS one
Maazi H,Singh AK,Speak AO,Lombardi V,Lam J,Khoo B,Inn KS,Sharpe AH,Jung JU,Akbari O
17-5961 was used in Flow cytometry/Cell sorting to investigate the effects of programmed death-1, and programmed death ligands 1 and 2 on invariant natural killer T cells in the response to influenza.
Mon Sep 30 00:00:00 UTC 2013
IRF7 regulates TLR2-mediated activation of splenic CD11c(hi) dendritic cells.
PloS one
Owens BM,Moore JW,Kaye PM
17-5961 was used in Flow cytometry/Cell sorting to suggest a previously unknown function for IRF7 as a component of the regulatory network associated with splenic dendritic cell activation.
Wed Jan 16 00:00:00 UTC 2013
Exogenous amino acids are essential for interleukin-7 induced CD8 T cell growth. [corrected].
PloS one
Pearson C,Silva A,Seddon B
17-5961 was used in Flow cytometry/Cell sorting to investigate the role of amino acid homeostasis for T cell survival and growth.
Mon Nov 19 00:00:00 UTC 2012
Lymphoma-like T cell infiltration in liver is associated with increased copy number of dominant negative form of TGFβ receptor II.
PloS one
Zhang W,Tsuda M,Yang GX,Tsuneyama K,He XS,Ansari AA,Ridgway WM,Coppel RL,Lian ZX,Leung PS,Gershwin ME
17-5961 was used in Flow cytometry/Cell sorting to further define the processes underlying the development of lymphoma-like T cell infiltration.
Tue Jun 25 00:00:00 UTC 2013
RUNX transcription factor-mediated association of Cd4 and Cd8 enables coordinate gene regulation.
Immunity
Collins A,Hewitt SL,Chaumeil J,Sellars M,Micsinai M,Allinne J,Parisi F,Nora EP,Bolland DJ,Corcoran AE,Kluger Y,Bosselut R,Ellmeier W,Chong MM,Littman DR,Skok JA
17-5961 was used in Flow cytometry/Cell sorting to study how communication between Cd4 and Cd8 appears to enable long-range epigenetic regulation to ensure that expression of one excludes the other in mature CD4 or CD8 single-positive cells.
Fri Mar 25 00:00:00 UTC 2011
Prostaglandin E2 suppresses the differentiation of retinoic acid-producing dendritic cells in mice and humans.
The Journal of experimental medicine
Stock A,Booth S,Cerundolo V
17-5961 was used in Flow cytometry/Cell sorting to study how PGE2 stimulates the expression of the inducible cyclic AMP early repressor, which appears to directly inhibit RALDH expression in DCs.
Mon Apr 11 00:00:00 UTC 2011
IL-7 determines the homeostatic fitness of T cells by distinct mechanisms at different signalling thresholds in vivo.
European journal of immunology
Pearson C,Silva A,Saini M,Seddon B
17-5961 was used in Flow cytometry/Cell sorting to study the molecular mechanisms by which IL-7 regulates the homeostatic fitness of T cells.
Thu Dec 01 00:00:00 UTC 2011
Restricted microbiota and absence of cognate TCR antigen leads to an unbalanced generation of Th17 cells.
Journal of immunology (Baltimore, Md. : 1950)
Lochner M,Bérard M,Sawa S,Hauer S,Gaboriau-Routhiau V,Fernandez TD,Snel J,Bousso P,Cerf-Bensussan N,Eberl G
17-5961 was used in Flow cytometry/Cell sorting to demonstrate that a complex microbiota and cognate antigen are required to generate a properly regulated set of Foxp3+RORγt+ T cells and Th17 cells.
Tue Feb 01 00:00:00 UTC 2011
PD-L1 and PD-L2 modulate airway inflammation and iNKT-cell-dependent airway hyperreactivity in opposing directions.
Mucosal immunology
Akbari O,Stock P,Singh AK,Lombardi V,Lee WL,Freeman GJ,Sharpe AH,Umetsu DT,Dekruyff RH
17-5961 was used in Flow cytometry/Cell sorting to investigate the roles of PD-L1 and PD-L2 in regulating invariant natural killer T cell mediated airway hyperreactivity in a mouse model of asthma.
Fri Jan 01 00:00:00 UTC 2010
Apoptotic cells activate NKT cells through T cell Ig-like mucin-like-1 resulting in airway hyperreactivity.
Journal of immunology (Baltimore, Md. : 1950)
Lee HH,Meyer EH,Goya S,Pichavant M,Kim HY,Bu X,Umetsu SE,Jones JC,Savage PB,Iwakura Y,Casasnovas JM,Kaplan G,Freeman GJ,DeKruyff RH,Umetsu DT
17-5961 was used in Flow cytometry/Cell sorting to elucidate the mechanism by which apoptotic cells activate pulmonary natural killer T cells to cause airway hyperreactivity.
Mon Nov 01 00:00:00 UTC 2010
Stromal cell independent B cell development in vitro: generation and recovery of autoreactive clones.
Journal of immunological methods
Holl TM,Haynes BF,Kelsoe G
17-5961 was used in Flow cytometry/Cell sorting to describe a stromal cell independent culture system that efficiently supports pro-B cell to IgM+ B cell development with near normal levels of IgH and Igkappa diversity.
Wed Mar 31 00:00:00 UTC 2010
Regulation of T cell-dendritic cell interactions by IL-7 governs T-cell activation and homeostasis.
Blood
Saini M,Pearson C,Seddon B
17-5961 was used in Flow cytometry/Cell sorting to examine in vitro and in vivo antigen-specific T-cell responses to viral infection and lymphopenia to determine whether IL-7 signalling influences TCR-triggered cell division events.
Thu Jun 04 00:00:00 UTC 2009
Lack of TNFR2 expression by CD4(+) T cells exacerbates experimental colitis.
European journal of immunology
Dayer Schneider J,Seibold I,Saxer-Sekulic N,Paredes BE,Saurer L,Mueller C
17-5961 was used in Flow cytometry/Cell sorting to assess the role of TNF receptor 2 signalling in the CD4(+) T-cell transfer model of colitis.
Wed Jul 01 00:00:00 UTC 2009
Id3 restricts the developmental potential of gamma delta lineage during thymopoiesis.
Journal of immunology (Baltimore, Md. : 1950)
Ueda-Hayakawa I,Mahlios J,Zhuang Y
17-5961 was used in Flow cytometry/Cell sorting to show that functional loss of Id3 increases gammadelta T cell production from progenitor cells undergoing TCRbeta rearrangement.
Fri May 01 00:00:00 UTC 2009
Resistance to lipopolysaccharide-induced preterm delivery mediated by regulatory T cell function in mice.
Biology of reproduction
Bizargity P,Del Rio R,Phillippe M,Teuscher C,Bonney EA
17-5961 was used in Flow cytometry/Cell sorting to examine the activities of innate immune cells and the importance of T and B cells, in the cellular network involved in preterm delivery (PTD).
Fri May 01 00:00:00 UTC 2009
Critical role of the interleukin-17/interleukin-17 receptor axis in regulating host susceptibility to respiratory infection with Chlamydia species.
Infection and immunity
Zhou X,Chen Q,Moore J,Kolls JK,Halperin S,Wang J
17-5961 was used in Flow cytometry/Cell sorting to demonstrate that Chlamydia stimulates IL-17/IL-17R-associated responses in Chlamydia-resistant and Chlamydia-susceptible mice.
Sun Nov 01 00:00:00 UTC 2009
In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cells.
The Journal of experimental medicine
Lochner M,Peduto L,Cherrier M,Sawa S,Langa F,Varona R,Riethmacher D,Si-Tahar M,Di Santo JP,Eberl G
17-5961 was used in Flow cytometry/Cell sorting to study how potentially antagonistic pro-inflammatory IL-17-producing and regulatory Foxp3(+) RORgamma t(+) T cells coexist and are tightly controlled.
Mon Jun 09 00:00:00 UTC 2008
Rescue of cytotoxic function in the CD8alpha knockout mouse by removal of MHC class II.
European journal of immunology
Riddle DS,Miller PJ,Vincent BG,Kepler TB,Maile R,Frelinger JA,Collins EJ
17-5961 was used in Flow cytometry/Cell sorting to demonstrate unequivocally that CD8 is not required for commitment of thymocytes to the cytolytic T cell lineage.
Sun Jun 01 00:00:00 UTC 2008
ICOS/ICOSL interaction is required for CD4+ invariant NKT cell function and homeostatic survival.
Journal of immunology (Baltimore, Md. : 1950)
Akbari O,Stock P,Meyer EH,Freeman GJ,Sharpe AH,Umetsu DT,DeKruyff RH
17-5961 was used in Flow cytometry/Cell sorting to investigate the role of ICOS and iNKT cells in the development of airway hyperreactivity.
Tue Apr 15 00:00:00 UTC 2008
Hierarchy of Notch-Delta interactions promoting T cell lineage commitment and maturation.
The Journal of experimental medicine
Besseyrias V,Fiorini E,Strobl LJ,Zimber-Strobl U,Dumortier A,Koch U,Arcangeli ML,Ezine S,Macdonald HR,Radtke F
17-5961 was used in Flow cytometry/Cell sorting to study the Notch-Delta interactions that promote T cell development.
Mon Feb 19 00:00:00 UTC 2007
Msx2-interacting nuclear target protein (Mint) deficiency reveals negative regulation of early thymocyte differentiation by Notch/RBP-J signaling.
Proceedings of the National Academy of Sciences of the United States of America
Tsuji M,Shinkura R,Kuroda K,Yabe D,Honjo T
17-5961-82 was used in Flow Cytometry to o investigate where and how Notch regulates early T cell differentiation by using specific up-regulation of Notch signaling by Mint knockout.
Tue Jan 30 00:00:00 UTC 2007
